在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PNPLA8 Antibody

  • 中文名稱:
    PNPLA8兔多克隆抗體
  • 貨號:
    CSB-PA868272LA01HU
  • 規格:
    ¥440
  • 圖片:
    • IHC image of CSB-PA868272LA01HU diluted at 1:400 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA868272LA01HU diluted at 1:400 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of A549 cells with CSB-PA868272LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PNPLA8 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PNPLA8
  • 別名:
    PNPLA8; IPLA22; IPLA2G; BM-043; Calcium-independent phospholipase A2-gamma; Intracellular membrane-associated calcium-independent phospholipase A2 gamma; iPLA2-gamma; PNPLA-gamma; Patatin-like phospholipase domain-containing protein 8; iPLA2-2
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Calcium-independent phospholipase A2-gamma protein (158-345AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,PNPLA8 Antibody (CSB-PA868272LA01HU),的標記方式是Non-conjugated。對于PNPLA8 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA868272LB01HU PNPLA8 Antibody, HRP conjugated ELISA
    FITC CSB-PA868272LC01HU PNPLA8 Antibody, FITC conjugated
    Biotin CSB-PA868272LD01HU PNPLA8 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Calcium-independent and membrane-bound phospholipase, that catalyzes the esterolytic cleavage of fatty acids from glycerophospholipids to yield free fatty acids and lysophospholipids, hence regulating membrane physical properties and the release of lipid second messengers and growth factors. Hydrolyzes phosphatidylethanolamine, phosphatidylcholine and probably phosphatidylinositol with a possible preference for the former. Has also a broad substrate specificity in terms of fatty acid moieties, hydrolyzing saturated and mono-unsaturated fatty acids at nearly equal rates from either the sn-1 or sn-2 position in diacyl phosphatidylcholine. However, has a weak activity toward polyunsaturated fatty acids at the sn-2 position, and thereby favors the production of 2-arachidonoyl lysophosphatidylcholine, a key branch point metabolite in eicosanoid signaling. On the other hand, can produce arachidonic acid from the sn-1 position of diacyl phospholipid and from the sn-2 position of arachidonate-containing plasmalogen substrates. Therefore, plays an important role in the mobilization of arachidonic acid in response to cellular stimuli and the generation of lipid second messengers. Can also hydrolyze lysophosphatidylcholine. In the mitochondrial compartment, catalyzes the hydrolysis and release of oxidized aliphatic chains from cardiolipin and integrates mitochondrial bioenergetics and signaling. It is essential for maintaining efficient bioenergetic mitochondrial function through tailoring mitochondrial membrane lipid metabolism and composition.
  • 基因功能參考文獻:
    1. Stable isotope kinetics revealed that in non-failing human hearts, cPLA2zeta metabolically channels arachidonic acid into EETs, whereas in failing hearts, increased iPLA2gamma activity channels AA into toxic HETEs. These results mechanistically identify the sequelae of pathological remodeling of human mitochondrial phospholipases in failing myocardium. PMID: 29158256
    2. iPLA2gamma plays an important role in in vivo Thromboxane A2 production accompanied by thrombus formation. PMID: 25313821
    3. iPLA2gamma plays a cardioprotective role during the acute stage of Chagas' disease. PMID: 23429536
    4. Thus, complement-mediated activation of iPLA(2)gamma is mediated via ERK and p38 pathways, and phosphorylation of Ser-511 and/or Ser-515 plays a key role in the catalytic activity and signaling of iPLA(2)gamma. PMID: 23258543
    5. These results suggest distinct roles for iPLA2beta and iPLA2gamma in cellular homeostasis and signaling, a functional link between peroxisomal AA release and eicosanoid generation, and a potential contribution of iPLA2gamma to tumorigenesis. PMID: 15695510
    6. iPLA2 activation is not sufficient for SOCE activation. iPLA2 may regulate basal phosphoinositide metabolism PMID: 18680539

    顯示更多

    收起更多

  • 相關疾病:
    Mitochondrial myopathy with lactic acidosis (MMLA)
  • 亞細胞定位:
    Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein.
  • 組織特異性:
    Expressed in parenchymal tissues including heart, skeletal muscle, placenta, brain, liver and pancreas. Also expressed in bronchial epithelial cells and kidney. Highest expression is observed in skeletal muscle and heart.
  • 數據庫鏈接:

    HGNC: 28900

    OMIM: 251950

    KEGG: hsa:50640

    STRING: 9606.ENSP00000257694

    UniGene: Hs.617340



主站蜘蛛池模板: 国产98色在线 | 国| 国产激情艳情在线看视频| 亚洲a∨无码一区二区| 欧美性xxxxx极品娇小| 少妇愉情理伦片丰满丰满午夜| 国产露脸精品产三级国产av| 亚洲欧美人成网站在线观看看| 浪货趴办公桌~h揉秘书电影| 欧美日韩在大午夜爽爽影院| 俄罗斯丰满熟妇hd| 久久96国产精品久久久| 亚洲精品无码av中文字幕电影网站| 99热久久这里只精品国产www | 最新精品视频2019在线视频| 色又黄又爽18禁免费网站| 成人免费ā片在线观看| а√资源新版在线天堂 | 国产成人久久av免费高潮| 丝袜无码一区二区三区| 成人综合网亚洲伊人| 日韩人妻精品无码一区二区三区| 国产97在线 | 亚洲| 老色鬼永久视频网站| 视频久re精品在线观看| 精品国产亚洲一区二区三区 | 性做久久久久久久久| 最新成年女人毛片免费基地| 久久er99国产精品免费| 亚洲精品一区久久久久| 97人人模人人爽人人喊网| 久久人人97超碰国产亚洲人| 少妇高潮无套内谢麻豆传| 精品少妇人妻av免费久久洗澡| 国产成人精品午夜福利| 久久久久77777人人人人人| av边做边流奶水无码免费| 精品国产乱码久久久久久婷婷| 久久先锋男人av资源网站| 欧美色欧美亚洲日韩在线播放| 亚洲aⅴ无码专区在线观看q| 亚洲人精品午夜射精日韩|