在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PNPLA8 Antibody

  • 中文名稱:
    PNPLA8兔多克隆抗體
  • 貨號:
    CSB-PA196783
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from HeLa cells, A549 cells and HUVEC cells, using PNPLA8 antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PNPLA8 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PNPLA8
  • 別名:
    PNPLA8; IPLA22; IPLA2G; BM-043; Calcium-independent phospholipase A2-gamma; Intracellular membrane-associated calcium-independent phospholipase A2 gamma; iPLA2-gamma; PNPLA-gamma; Patatin-like phospholipase domain-containing protein 8; iPLA2-2
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from internal of Human PNPLA8.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Calcium-independent and membrane-bound phospholipase, that catalyzes the esterolytic cleavage of fatty acids from glycerophospholipids to yield free fatty acids and lysophospholipids, hence regulating membrane physical properties and the release of lipid second messengers and growth factors. Hydrolyzes phosphatidylethanolamine, phosphatidylcholine and probably phosphatidylinositol with a possible preference for the former. Has also a broad substrate specificity in terms of fatty acid moieties, hydrolyzing saturated and mono-unsaturated fatty acids at nearly equal rates from either the sn-1 or sn-2 position in diacyl phosphatidylcholine. However, has a weak activity toward polyunsaturated fatty acids at the sn-2 position, and thereby favors the production of 2-arachidonoyl lysophosphatidylcholine, a key branch point metabolite in eicosanoid signaling. On the other hand, can produce arachidonic acid from the sn-1 position of diacyl phospholipid and from the sn-2 position of arachidonate-containing plasmalogen substrates. Therefore, plays an important role in the mobilization of arachidonic acid in response to cellular stimuli and the generation of lipid second messengers. Can also hydrolyze lysophosphatidylcholine. In the mitochondrial compartment, catalyzes the hydrolysis and release of oxidized aliphatic chains from cardiolipin and integrates mitochondrial bioenergetics and signaling. It is essential for maintaining efficient bioenergetic mitochondrial function through tailoring mitochondrial membrane lipid metabolism and composition.
  • 基因功能參考文獻:
    1. Stable isotope kinetics revealed that in non-failing human hearts, cPLA2zeta metabolically channels arachidonic acid into EETs, whereas in failing hearts, increased iPLA2gamma activity channels AA into toxic HETEs. These results mechanistically identify the sequelae of pathological remodeling of human mitochondrial phospholipases in failing myocardium. PMID: 29158256
    2. iPLA2gamma plays an important role in in vivo Thromboxane A2 production accompanied by thrombus formation. PMID: 25313821
    3. iPLA2gamma plays a cardioprotective role during the acute stage of Chagas' disease. PMID: 23429536
    4. Thus, complement-mediated activation of iPLA(2)gamma is mediated via ERK and p38 pathways, and phosphorylation of Ser-511 and/or Ser-515 plays a key role in the catalytic activity and signaling of iPLA(2)gamma. PMID: 23258543
    5. These results suggest distinct roles for iPLA2beta and iPLA2gamma in cellular homeostasis and signaling, a functional link between peroxisomal AA release and eicosanoid generation, and a potential contribution of iPLA2gamma to tumorigenesis. PMID: 15695510
    6. iPLA2 activation is not sufficient for SOCE activation. iPLA2 may regulate basal phosphoinositide metabolism PMID: 18680539

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Mitochondrial myopathy with lactic acidosis (MMLA)
  • 亞細胞定位:
    Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein.
  • 組織特異性:
    Expressed in parenchymal tissues including heart, skeletal muscle, placenta, brain, liver and pancreas. Also expressed in bronchial epithelial cells and kidney. Highest expression is observed in skeletal muscle and heart.
  • 數據庫鏈接:

    HGNC: 28900

    OMIM: 251950

    KEGG: hsa:50640

    STRING: 9606.ENSP00000257694

    UniGene: Hs.617340



主站蜘蛛池模板: 久久精品日韩av无码| 国产精品涩涩涩视频网站| 中文字幕无码免费久久| 亚洲乱码日产精品bd在线观看| 在线观看国产精品电影| 亚洲国产最大av| 呻吟国产av久久一区二区| 青草草97久热精品视频| 18禁免费吃奶摸下激烈视频| 无码精品尤物一区二区三区| 亚洲精品国产精品乱码不99| 国产成人精品日本亚洲一区| 亚洲综合无码一区二区痴汉| 很黄很黄的曰批视频| 久久午夜无码鲁丝片| 国产又粗又猛又大爽又黄| 99精品国产在热久久无码| 国产美女午夜福利视频| 亚洲欧美人成电影在线观看| 欧美日韩不卡合集视频| 鲁丝一区二区三区免费| 成全世界免费高清观看| 精品国产av最大网站| 亚洲图片综合图区20p| 中文字幕美人妻亅u乚一596| 人妻aⅴ无码一区二区三区| 日日做夜狠狠爱欧美黑人| 日韩a人毛片精品无人区乱码| 日本少妇自慰免费完整版| 少妇性l交大片欧洲热妇乱xxx| 青青草国产成人99久久| 欧美日韩中文国产一区发布| 午夜片无码区私人影院| 久久综合给综合给久久| 美国特级a毛片免费网站| 国产精品99久久久久久董美香| 丁香五香天堂网| 国产99视频精品专区| 人妻无码专区一区二区三区| 成人性生交大片免费看视频app | 免费观看性欧美大片无片|