在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PNPLA8 Antibody, Biotin conjugated

  • 中文名稱:
    PNPLA8兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA868272LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PNPLA8 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PNPLA8
  • 別名:
    PNPLA8; IPLA22; IPLA2G; BM-043; Calcium-independent phospholipase A2-gamma; Intracellular membrane-associated calcium-independent phospholipase A2 gamma; iPLA2-gamma; PNPLA-gamma; Patatin-like phospholipase domain-containing protein 8; iPLA2-2
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Calcium-independent phospholipase A2-gamma protein (158-345AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Calcium-independent and membrane-bound phospholipase, that catalyzes the esterolytic cleavage of fatty acids from glycerophospholipids to yield free fatty acids and lysophospholipids, hence regulating membrane physical properties and the release of lipid second messengers and growth factors. Hydrolyzes phosphatidylethanolamine, phosphatidylcholine and probably phosphatidylinositol with a possible preference for the former. Has also a broad substrate specificity in terms of fatty acid moieties, hydrolyzing saturated and mono-unsaturated fatty acids at nearly equal rates from either the sn-1 or sn-2 position in diacyl phosphatidylcholine. However, has a weak activity toward polyunsaturated fatty acids at the sn-2 position, and thereby favors the production of 2-arachidonoyl lysophosphatidylcholine, a key branch point metabolite in eicosanoid signaling. On the other hand, can produce arachidonic acid from the sn-1 position of diacyl phospholipid and from the sn-2 position of arachidonate-containing plasmalogen substrates. Therefore, plays an important role in the mobilization of arachidonic acid in response to cellular stimuli and the generation of lipid second messengers. Can also hydrolyze lysophosphatidylcholine. In the mitochondrial compartment, catalyzes the hydrolysis and release of oxidized aliphatic chains from cardiolipin and integrates mitochondrial bioenergetics and signaling. It is essential for maintaining efficient bioenergetic mitochondrial function through tailoring mitochondrial membrane lipid metabolism and composition.
  • 基因功能參考文獻:
    1. Stable isotope kinetics revealed that in non-failing human hearts, cPLA2zeta metabolically channels arachidonic acid into EETs, whereas in failing hearts, increased iPLA2gamma activity channels AA into toxic HETEs. These results mechanistically identify the sequelae of pathological remodeling of human mitochondrial phospholipases in failing myocardium. PMID: 29158256
    2. iPLA2gamma plays an important role in in vivo Thromboxane A2 production accompanied by thrombus formation. PMID: 25313821
    3. iPLA2gamma plays a cardioprotective role during the acute stage of Chagas' disease. PMID: 23429536
    4. Thus, complement-mediated activation of iPLA(2)gamma is mediated via ERK and p38 pathways, and phosphorylation of Ser-511 and/or Ser-515 plays a key role in the catalytic activity and signaling of iPLA(2)gamma. PMID: 23258543
    5. These results suggest distinct roles for iPLA2beta and iPLA2gamma in cellular homeostasis and signaling, a functional link between peroxisomal AA release and eicosanoid generation, and a potential contribution of iPLA2gamma to tumorigenesis. PMID: 15695510
    6. iPLA2 activation is not sufficient for SOCE activation. iPLA2 may regulate basal phosphoinositide metabolism PMID: 18680539

    顯示更多

    收起更多

  • 相關疾病:
    Mitochondrial myopathy with lactic acidosis (MMLA)
  • 亞細胞定位:
    Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein.
  • 組織特異性:
    Expressed in parenchymal tissues including heart, skeletal muscle, placenta, brain, liver and pancreas. Also expressed in bronchial epithelial cells and kidney. Highest expression is observed in skeletal muscle and heart.
  • 數據庫鏈接:

    HGNC: 28900

    OMIM: 251950

    KEGG: hsa:50640

    STRING: 9606.ENSP00000257694

    UniGene: Hs.617340



主站蜘蛛池模板: 亚洲精品国产一区二区图片| 婷婷色香合缴缴情av第三区| 欧美激情猛片xxxⅹ大3| 免费人成视频在线播放视频| 图片区 小说区 区 亚洲五月| 99精品国产在热久久婷婷| 国产亚洲精品ae86| 人妻.中文字幕无码| 人妻在卧室被老板疯狂进入| av怡红院一区二区三区| 四库影院永久国产精品| 久久亚洲精品无码av红樱桃| 国产成人精品999在线观看| 囯产精品一品二区三区| 孕妇怀孕高潮潮喷视频孕妇| 成年无码动漫av片在线尤物网站| 日韩乱码人妻无码超清蜜桃| 柠檬福利精品视频导航| 4480yy私人精品国产| 久久久久国色av免费观看性色| 久久久久女教师免费一区| 四虎国产精亚洲一区久久特色| 亚洲精品无码久久久久秋霞 | 久久人妻无码中文字幕| 七妺福利精品导航大全| 欧洲精品一线二线三线区别| 夜夜爽妓女8888视频免费观看| 亚洲综合小说另类图片五月天| 一区二区三区毛aaaa片特级| 无码人妻少妇色欲av一区二区| 大战熟女丰满人妻av| 美女粉嫩饱满的一线天mp4| 日韩精品无码熟人妻视频| 99久久综合精品五月天| 国产又黄又爽又色的免费| 久久精品中文字幕有码| 亚洲国产成人精品女人久久久| 亚洲欧洲∨国产一区二区三区| 日韩欧美国产一区精品| 大地资源中文第三页| 日本高清视频网站www|