在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PNPLA8 Antibody

  • 中文名稱:
    PNPLA8兔多克隆抗體
  • 貨號(hào):
    CSB-PA003057
  • 規(guī)格:
    ¥1090
  • 圖片:
    • Western Blot analysis of HeLa cells using iPLA2γ Polyclonal Antibody
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    PNPLA8
  • 別名:
    PNPLA8; IPLA22; IPLA2G; BM-043; Calcium-independent phospholipase A2-gamma; Intracellular membrane-associated calcium-independent phospholipase A2 gamma; iPLA2-gamma; PNPLA-gamma; Patatin-like phospholipase domain-containing protein 8; iPLA2-2
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from the C-terminal region of Human iPLA2γ.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Calcium-independent and membrane-bound phospholipase, that catalyzes the esterolytic cleavage of fatty acids from glycerophospholipids to yield free fatty acids and lysophospholipids, hence regulating membrane physical properties and the release of lipid second messengers and growth factors. Hydrolyzes phosphatidylethanolamine, phosphatidylcholine and probably phosphatidylinositol with a possible preference for the former. Has also a broad substrate specificity in terms of fatty acid moieties, hydrolyzing saturated and mono-unsaturated fatty acids at nearly equal rates from either the sn-1 or sn-2 position in diacyl phosphatidylcholine. However, has a weak activity toward polyunsaturated fatty acids at the sn-2 position, and thereby favors the production of 2-arachidonoyl lysophosphatidylcholine, a key branch point metabolite in eicosanoid signaling. On the other hand, can produce arachidonic acid from the sn-1 position of diacyl phospholipid and from the sn-2 position of arachidonate-containing plasmalogen substrates. Therefore, plays an important role in the mobilization of arachidonic acid in response to cellular stimuli and the generation of lipid second messengers. Can also hydrolyze lysophosphatidylcholine. In the mitochondrial compartment, catalyzes the hydrolysis and release of oxidized aliphatic chains from cardiolipin and integrates mitochondrial bioenergetics and signaling. It is essential for maintaining efficient bioenergetic mitochondrial function through tailoring mitochondrial membrane lipid metabolism and composition.
  • 基因功能參考文獻(xiàn):
    1. Stable isotope kinetics revealed that in non-failing human hearts, cPLA2zeta metabolically channels arachidonic acid into EETs, whereas in failing hearts, increased iPLA2gamma activity channels AA into toxic HETEs. These results mechanistically identify the sequelae of pathological remodeling of human mitochondrial phospholipases in failing myocardium. PMID: 29158256
    2. iPLA2gamma plays an important role in in vivo Thromboxane A2 production accompanied by thrombus formation. PMID: 25313821
    3. iPLA2gamma plays a cardioprotective role during the acute stage of Chagas' disease. PMID: 23429536
    4. Thus, complement-mediated activation of iPLA(2)gamma is mediated via ERK and p38 pathways, and phosphorylation of Ser-511 and/or Ser-515 plays a key role in the catalytic activity and signaling of iPLA(2)gamma. PMID: 23258543
    5. These results suggest distinct roles for iPLA2beta and iPLA2gamma in cellular homeostasis and signaling, a functional link between peroxisomal AA release and eicosanoid generation, and a potential contribution of iPLA2gamma to tumorigenesis. PMID: 15695510
    6. iPLA2 activation is not sufficient for SOCE activation. iPLA2 may regulate basal phosphoinositide metabolism PMID: 18680539

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Mitochondrial myopathy with lactic acidosis (MMLA)
  • 亞細(xì)胞定位:
    Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein.
  • 組織特異性:
    Expressed in parenchymal tissues including heart, skeletal muscle, placenta, brain, liver and pancreas. Also expressed in bronchial epithelial cells and kidney. Highest expression is observed in skeletal muscle and heart.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 28900

    OMIM: 251950

    KEGG: hsa:50640

    STRING: 9606.ENSP00000257694

    UniGene: Hs.617340



主站蜘蛛池模板: 天天躁夜夜躁狠狠躁2020| 人妻aⅴ无码一区二区三区| 亚洲人成无码网www电影麻豆 | 亚洲日韩精品欧美一区二区| 夜夜爽狠狠天天婷婷五月| 国产日韩亚洲大尺度高清 | 国产午夜精品理论片| 亚洲综合色区另类小说 | 电影久久久久久| 欧美成年网站色a| 久久综合九色综合欧美98| 黑巨人与欧美精品一区| 国产午夜a理论毛片| 国产裸体xxxx视频| 亚洲欧美精品aaaaaa片| 99re6热精品视频在线观看| 国语对白嫖老妇胖老太| 国产成人av一区二区三区在线观看 | 免费ā片在线观看| 日日av色欲香天天综合网| 国产成人精品999视频| 亚洲情综合五月天| 国产精品国产三级国产aⅴ下载| 2020精品国产午夜福利在线观看| 狠狠色丁香久久综合| 国产精品特级露脸av毛片| 亚洲 欧美 成人 自拍 高清| 无码精品人妻一区二区三区98| 国产精品成人av在线观看| 人人妻人人澡人人爽欧美一区九九| 免费的av网站在线观看国产精品| 国产成人高清精品亚洲| 日韩av无码精品人妻系列| 国产精品一区波多野结衣| 国产又黄又湿无遮挡免费视频 | 久久久久无码国产精品不卡| 午夜福利麻豆国产精品| 欧美老妇疯狂xxxxbbbb| 中文无码伦av中文字幕 | 亚洲精品综合在线影院 | 欧美日产欧美日产国产精品|