在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PNPLA8 Antibody

  • 中文名稱:
    PNPLA8兔多克隆抗體
  • 貨號(hào):
    CSB-PA003057
  • 規(guī)格:
    ¥1090
  • 圖片:
    • Western Blot analysis of HeLa cells using iPLA2γ Polyclonal Antibody
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    PNPLA8
  • 別名:
    PNPLA8; IPLA22; IPLA2G; BM-043; Calcium-independent phospholipase A2-gamma; Intracellular membrane-associated calcium-independent phospholipase A2 gamma; iPLA2-gamma; PNPLA-gamma; Patatin-like phospholipase domain-containing protein 8; iPLA2-2
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from the C-terminal region of Human iPLA2γ.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Calcium-independent and membrane-bound phospholipase, that catalyzes the esterolytic cleavage of fatty acids from glycerophospholipids to yield free fatty acids and lysophospholipids, hence regulating membrane physical properties and the release of lipid second messengers and growth factors. Hydrolyzes phosphatidylethanolamine, phosphatidylcholine and probably phosphatidylinositol with a possible preference for the former. Has also a broad substrate specificity in terms of fatty acid moieties, hydrolyzing saturated and mono-unsaturated fatty acids at nearly equal rates from either the sn-1 or sn-2 position in diacyl phosphatidylcholine. However, has a weak activity toward polyunsaturated fatty acids at the sn-2 position, and thereby favors the production of 2-arachidonoyl lysophosphatidylcholine, a key branch point metabolite in eicosanoid signaling. On the other hand, can produce arachidonic acid from the sn-1 position of diacyl phospholipid and from the sn-2 position of arachidonate-containing plasmalogen substrates. Therefore, plays an important role in the mobilization of arachidonic acid in response to cellular stimuli and the generation of lipid second messengers. Can also hydrolyze lysophosphatidylcholine. In the mitochondrial compartment, catalyzes the hydrolysis and release of oxidized aliphatic chains from cardiolipin and integrates mitochondrial bioenergetics and signaling. It is essential for maintaining efficient bioenergetic mitochondrial function through tailoring mitochondrial membrane lipid metabolism and composition.
  • 基因功能參考文獻(xiàn):
    1. Stable isotope kinetics revealed that in non-failing human hearts, cPLA2zeta metabolically channels arachidonic acid into EETs, whereas in failing hearts, increased iPLA2gamma activity channels AA into toxic HETEs. These results mechanistically identify the sequelae of pathological remodeling of human mitochondrial phospholipases in failing myocardium. PMID: 29158256
    2. iPLA2gamma plays an important role in in vivo Thromboxane A2 production accompanied by thrombus formation. PMID: 25313821
    3. iPLA2gamma plays a cardioprotective role during the acute stage of Chagas' disease. PMID: 23429536
    4. Thus, complement-mediated activation of iPLA(2)gamma is mediated via ERK and p38 pathways, and phosphorylation of Ser-511 and/or Ser-515 plays a key role in the catalytic activity and signaling of iPLA(2)gamma. PMID: 23258543
    5. These results suggest distinct roles for iPLA2beta and iPLA2gamma in cellular homeostasis and signaling, a functional link between peroxisomal AA release and eicosanoid generation, and a potential contribution of iPLA2gamma to tumorigenesis. PMID: 15695510
    6. iPLA2 activation is not sufficient for SOCE activation. iPLA2 may regulate basal phosphoinositide metabolism PMID: 18680539

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Mitochondrial myopathy with lactic acidosis (MMLA)
  • 亞細(xì)胞定位:
    Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein.
  • 組織特異性:
    Expressed in parenchymal tissues including heart, skeletal muscle, placenta, brain, liver and pancreas. Also expressed in bronchial epithelial cells and kidney. Highest expression is observed in skeletal muscle and heart.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 28900

    OMIM: 251950

    KEGG: hsa:50640

    STRING: 9606.ENSP00000257694

    UniGene: Hs.617340



主站蜘蛛池模板: 中文字幕精品一二三四五六七八| 久久青青草原国产精品最新片| 麻豆国产成人av在线播放欲色 | 免费无遮挡禁18污污网站| a狠狠久久蜜臀婷色中文网| 精品国产卡一卡2卡3卡| 亚洲中文字幕无码中文字| 无码一区二区波多野结衣播放搜索| 亚洲日韩看片无码电影| 久久高清超碰av热热久久| 无码专区久久综合久中文字幕| 欧美一区二区| 久久精品99av高久久精品 | 国产末成年av在线播放| 成年轻人网站色直接看| 国产无遮挡吃胸膜奶免费看| 国偷自产一区二区免费视频| 国产 | 欧洲野花视频欧洲1| 国产精品自在在线午夜免费 | 美女被张开双腿日出白浆| 2021无码天堂在线| 亚洲色欲色欲www在线丝| 国产高清视频一区三区| 免费女上男下xx00xx00视频| 亚洲精品一区二区三区影院| 扒开双腿疯狂进出爽爽爽| 成人啪啪高潮不断观看| 久久精品日日躁夜夜躁| 8888四色奇米在线观看| 337p粉嫩日本欧洲亚洲大胆| 国产亚洲熟妇在线视频| 九九九精品成人免费视频小说| 国产午夜视频在线观看| 麻豆传煤入口免费进入2023| 久久亚洲色www成人不卡| 一二三四在线视频社区3| 国产互换人妻hd| 久久精品国产99久久久小说| 亚洲精品一区久久久久久| 国产情侣一区二区三区| 午夜视频在线在免费|