在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PEAK1 Antibody

PEAK1 Antibody

  • 中文名稱：
    PEAK1兔多克隆抗體
  • 貨號：
    CSB-PA875688LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA875688LA01HU diluted at 1:200 and staining in paraffin-embedded human appendix tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PEAK1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PEAK1
  • 別名：
    FLJ21140 antibody; FLJ34483 antibody; KIAA2002 antibody; NKF3 kinase family member antibody; PEAK1 antibody; PEAK1_HUMAN antibody; pseudopodium enriched atypical kinase antibody; Pseudopodium-enriched atypical kinase 1 antibody; SGK269 antibody; Sugen kinase 269 antibody; Tyrosine-protein kinase SgK269 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Pseudopodium-enriched atypical kinase 1 protein (715-881AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，PEAK1 Antibody (CSB-PA875688LA01HU)，的標(biāo)記方式是Non-conjugated。對于PEAK1 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA875688LB01HU PEAK1 Antibody, HRP conjugated ELISA
    FITC CSB-PA875688LC01HU PEAK1 Antibody, FITC conjugated
    Biotin CSB-PA875688LD01HU PEAK1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics. Acts as a scaffold for mediating EGFR signaling.
  • 基因功能參考文獻(xiàn)：
    1. PEAK1's kinase cleft is occluded, and its newly identified SHED region may promote an unexpected dimerization mode. Similarities of PEAK1 with the active kinase PINK1 may reclassify the latter as a member of the new kinase family 3 group. PMID: 29212708
    2. the critical role of the CH region in SgK269/SgK223 association. Importantly, although SgK269 bridged SgK223 to Grb2, it was unable to activate Stat3 or efficiently enhance migration in SgK223 knock-out cells generated by CRISPR/Cas9. PMID: 27531744
    3. Findings indicate that eIF5A-PEAK1-YAP signaling contributes to PDAC development by regulating an STF program associated with increased tumorigenicity. PMID: 28381547
    4. report is the first to provide evidence that PEAK1 mediates signaling cross talk between TGFbeta receptors and integrin/Src/MAPK pathways and that PEAK1 is an important molecular regulator of TGFbeta-induced tumor progression and metastasis in breast cancer PMID: 26267863
    5. this regard, we have demonstrated that PEAK1 is necessary for TGFbeta to induce ZEB1-mediated EMT in the context of fibronectin/ITGB3 activation. PMID: 26297948
    6. Suggest that loss of PEAK1/E-cadherin may play an important role in carcinogenesis and development of gastric cancer through activating epithelial to mesenchymal transition. PMID: 25445115
    7. eIF5A proteins utilize PEAK1 as a downstream effector to drive pancreatic ductal adenocarcinoma (PDAC) pathogenesis. PMID: 25261239
    8. results define a novel signaling pathway in basal breast cancer involving Lyn and SgK269 that offers clinical opportunities for therapeutic intervention PMID: 23378338
    9. phosphorylation of tyrosine 665 in pseudopodium-enriched atypical kinase 1 (PEAK1) is essential for the regulation of cell migration and focal adhesion turnover PMID: 23105102
    10. Here, we report that the novel tyrosine kinase PEAK1 is upregulated in human malignancies, including human PDACs and pancreatic intraepithelial neoplasia (PanIN). PMID: 22589274
    11. Also known as SgK269. Contains a divergent and possibly inactive eukaryotic protein kinase domain. Has one human paralog, known as SgK223 or pragmin. These two constitute the NKF3 subfamily of protein kinases, found in vertebrates and echinoderms PMID: 12471243

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm, cytoskeleton. Cell junction, focal adhesion.
  • 蛋白家族：
    Protein kinase superfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 29431

    OMIM: 614248

    KEGG: hsa:79834

    STRING: 9606.ENSP00000309230

    UniGene: Hs.731402



主站蜘蛛池模板： 少妇愉情理伦片高潮日本| 伊人久久大香线蕉av成人| 亚洲v天堂v手机在线| 66lu国产在线观看| 麻豆一区二区三区精品视频| 国产精品亚洲一区二区三区喷水| 国产免费啪嗒啪嗒视频看看| 国产丝袜在线精品丝袜| 区二区三区国产精华液区别大吗| 国产精品久久久久久久久久| 日本少妇裸体做爰高潮片 | 丝袜 亚洲 另类 欧美 变态| 亚洲精品乱码久久久久久蜜桃图片 | 色综合视频一区二区三区44| 中国极品少妇videossexhd| 亚洲伊人色欲综合网| 无码精品久久一区二区三区| 亚洲国产成人最新精品| 亚洲欲色欲色xxxxx在线| 国产精品 视频一区 二区三区| 国产亚洲日韩欧美一区二区三区| 少妇高潮流白浆在线观看| 亚洲日产韩国一二三四区| 日韩亚洲国产中文永久| 久久精品aⅴ无码中文字字幕蜜桃 午夜成人鲁丝片午夜精品 | 精品三级久久久久电影网| 色欲天天婬色婬香视频综合网| 色优久久久久综合网鬼色| 在线精品国产一区二区三区| 亚洲日韩精品欧美一区二区一| 无码人妻aⅴ一区二区三区玉蒲团| 成人免费无码大片a毛片户外| 久久久精品一区aaa片| 亚洲成av人在线视| 国产成人综合亚洲精品| 免费看国产zzzwww色| 欧美人妻一区二区三区| 国产成人亚洲综合精品| 精品国产v无码大片在线观看| 亚洲人成人无码www影院| 婷婷丁香社区|