在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PEAK1 Antibody, Biotin conjugated

  • 中文名稱:
    PEAK1兔多克隆抗體, Biotin偶聯(lián)
  • 貨號:
    CSB-PA875688LD01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) PEAK1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PEAK1
  • 別名:
    FLJ21140 antibody; FLJ34483 antibody; KIAA2002 antibody; NKF3 kinase family member antibody; PEAK1 antibody; PEAK1_HUMAN antibody; pseudopodium enriched atypical kinase antibody; Pseudopodium-enriched atypical kinase 1 antibody; SGK269 antibody; Sugen kinase 269 antibody; Tyrosine-protein kinase SgK269 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Pseudopodium-enriched atypical kinase 1 protein (715-881AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics. Acts as a scaffold for mediating EGFR signaling.
  • 基因功能參考文獻:
    1. PEAK1's kinase cleft is occluded, and its newly identified SHED region may promote an unexpected dimerization mode. Similarities of PEAK1 with the active kinase PINK1 may reclassify the latter as a member of the new kinase family 3 group. PMID: 29212708
    2. the critical role of the CH region in SgK269/SgK223 association. Importantly, although SgK269 bridged SgK223 to Grb2, it was unable to activate Stat3 or efficiently enhance migration in SgK223 knock-out cells generated by CRISPR/Cas9. PMID: 27531744
    3. Findings indicate that eIF5A-PEAK1-YAP signaling contributes to PDAC development by regulating an STF program associated with increased tumorigenicity. PMID: 28381547
    4. report is the first to provide evidence that PEAK1 mediates signaling cross talk between TGFbeta receptors and integrin/Src/MAPK pathways and that PEAK1 is an important molecular regulator of TGFbeta-induced tumor progression and metastasis in breast cancer PMID: 26267863
    5. this regard, we have demonstrated that PEAK1 is necessary for TGFbeta to induce ZEB1-mediated EMT in the context of fibronectin/ITGB3 activation. PMID: 26297948
    6. Suggest that loss of PEAK1/E-cadherin may play an important role in carcinogenesis and development of gastric cancer through activating epithelial to mesenchymal transition. PMID: 25445115
    7. eIF5A proteins utilize PEAK1 as a downstream effector to drive pancreatic ductal adenocarcinoma (PDAC) pathogenesis. PMID: 25261239
    8. results define a novel signaling pathway in basal breast cancer involving Lyn and SgK269 that offers clinical opportunities for therapeutic intervention PMID: 23378338
    9. phosphorylation of tyrosine 665 in pseudopodium-enriched atypical kinase 1 (PEAK1) is essential for the regulation of cell migration and focal adhesion turnover PMID: 23105102
    10. Here, we report that the novel tyrosine kinase PEAK1 is upregulated in human malignancies, including human PDACs and pancreatic intraepithelial neoplasia (PanIN). PMID: 22589274
    11. Also known as SgK269. Contains a divergent and possibly inactive eukaryotic protein kinase domain. Has one human paralog, known as SgK223 or pragmin. These two constitute the NKF3 subfamily of protein kinases, found in vertebrates and echinoderms PMID: 12471243

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytoskeleton. Cell junction, focal adhesion.
  • 蛋白家族:
    Protein kinase superfamily
  • 數(shù)據(jù)庫鏈接:

    HGNC: 29431

    OMIM: 614248

    KEGG: hsa:79834

    STRING: 9606.ENSP00000309230

    UniGene: Hs.731402



主站蜘蛛池模板: 天天摸天天做天天爽水多| 亚洲欧美日韩国产成人一区| 高清国产av一区二区三区| 亚洲国产精华液网站w| 欧美性生 活18~19| 国产成人综合久久精品推最新| 久久精品国产只有精品66| 一道本在线伊人蕉无码| 午夜福利一区二区三区在线观看| 无码国产成人午夜视频在线播放| 青椒国产97在线熟女| 国产又爽又粗又猛的视频| 国产精品污www在线观看| 国产成人久久综合77777| 最新国产成人无码久久| 三上悠亚久久精品| 成人精品一区二区三区中文字幕| 四虎永久在线精品免费观看视频| 精品国产卡一卡2卡3卡| 狠狠色综合tv久久久久久| 日韩成人无码| 中文字幕丰满乱子无码视频| 国产鲁鲁视频在线观看| 先锋影音最新色资源站| 超碰cao已满18进入离开官网| 老女老肥熟国产在线视频| 中国极品少妇xxxxx| 在线视频夫妻内射| 少妇无码av无码一区| 亚洲一区二区三区av天堂| 国精产品999国精产| 真实国产乱子伦精品一区二区三区| 免费观看日本污污ww网站| 日本视频高清一道一区| 99久久国产精品免费高潮| 久精品视频在线观看免费| 亚洲色精品aⅴ一区区三区| 九九精品成人免费国产片| 偷自拍亚洲视频在线观看99| 亚洲爆乳精品无码一区二区| 18禁止进入1000部高潮网站|