在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PEAK1 Antibody

  • 中文名稱:
    PEAK1兔多克隆抗體
  • 貨號:
    CSB-PA981746
  • 規(guī)格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from 3T3 cells, using SGK269 antibody.
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) PEAK1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PEAK1
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from N-terminal of Human SGK269.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics. Acts as a scaffold for mediating EGFR signaling.
  • 基因功能參考文獻:
    1. PEAK1's kinase cleft is occluded, and its newly identified SHED region may promote an unexpected dimerization mode. Similarities of PEAK1 with the active kinase PINK1 may reclassify the latter as a member of the new kinase family 3 group. PMID: 29212708
    2. the critical role of the CH region in SgK269/SgK223 association. Importantly, although SgK269 bridged SgK223 to Grb2, it was unable to activate Stat3 or efficiently enhance migration in SgK223 knock-out cells generated by CRISPR/Cas9. PMID: 27531744
    3. Findings indicate that eIF5A-PEAK1-YAP signaling contributes to PDAC development by regulating an STF program associated with increased tumorigenicity. PMID: 28381547
    4. report is the first to provide evidence that PEAK1 mediates signaling cross talk between TGFbeta receptors and integrin/Src/MAPK pathways and that PEAK1 is an important molecular regulator of TGFbeta-induced tumor progression and metastasis in breast cancer PMID: 26267863
    5. this regard, we have demonstrated that PEAK1 is necessary for TGFbeta to induce ZEB1-mediated EMT in the context of fibronectin/ITGB3 activation. PMID: 26297948
    6. Suggest that loss of PEAK1/E-cadherin may play an important role in carcinogenesis and development of gastric cancer through activating epithelial to mesenchymal transition. PMID: 25445115
    7. eIF5A proteins utilize PEAK1 as a downstream effector to drive pancreatic ductal adenocarcinoma (PDAC) pathogenesis. PMID: 25261239
    8. results define a novel signaling pathway in basal breast cancer involving Lyn and SgK269 that offers clinical opportunities for therapeutic intervention PMID: 23378338
    9. phosphorylation of tyrosine 665 in pseudopodium-enriched atypical kinase 1 (PEAK1) is essential for the regulation of cell migration and focal adhesion turnover PMID: 23105102
    10. Here, we report that the novel tyrosine kinase PEAK1 is upregulated in human malignancies, including human PDACs and pancreatic intraepithelial neoplasia (PanIN). PMID: 22589274
    11. Also known as SgK269. Contains a divergent and possibly inactive eukaryotic protein kinase domain. Has one human paralog, known as SgK223 or pragmin. These two constitute the NKF3 subfamily of protein kinases, found in vertebrates and echinoderms PMID: 12471243

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytoskeleton. Cell junction, focal adhesion.
  • 蛋白家族:
    Protein kinase superfamily
  • 數(shù)據(jù)庫鏈接:

    HGNC: 29431

    OMIM: 614248

    KEGG: hsa:79834

    STRING: 9606.ENSP00000309230

    UniGene: Hs.731402



主站蜘蛛池模板: 亚洲精品国产一区二区图片| 人禽无码视频在线观看| 97久久久人妻一区精品| 久久精品成人欧美大片| 欧美日韩亚洲国产在线制服| 午夜成人鲁丝片午夜精品| 男女啪祼交视频| 久久久久久国产精品美女| 羞涩的丰满人妻40p| 国产成人av一区二区在线观看| 亚洲欧美国产精品久久久久久久| 又黄又爽又高潮免费毛片| 日韩视频无码免费一区=区三区| 精品av综合导航| 熟妇女人妻丰满少妇中文字幕 | 久久精品国产精品亚洲下载| 亚洲精品国产自在久久| 国产熟女高潮视频| 久久久久久av无码免费网站下载| 香港经典a毛片免费观看hd | 国内揄拍高清国内精品对白 | 神马午夜福利不卡片在线| 伊人久久大香线蕉无码不卡| 亚洲中文字幕无码中字| 97免费公开在线视频| 欧美另类又黄又爽的a片| 精品一区二区三区四区五区六区| 一 级做人爱全视频在线看| 巨胸喷奶水视频www免费网站| 2019久久久最新精品| 亚洲精品一区国产精品| 久久99国产精品成人| 亚洲成a人片在线观看天堂| 国产精品99久久久久久宅男 | 亚洲精品国产成人| 牛和人交xxxx欧美| 色avav色av爱avav亚洲色拍| 99久久精品视香蕉蕉| 日韩va中文字幕无码电影 | 香港三级韩国三级日本三级| 日韩人妻无码精品久久|