在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PEAK1 Antibody

  • 中文名稱:
    PEAK1兔多克隆抗體
  • 貨號:
    CSB-PA981746
  • 規(guī)格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from 3T3 cells, using SGK269 antibody.
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) PEAK1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PEAK1
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from N-terminal of Human SGK269.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics. Acts as a scaffold for mediating EGFR signaling.
  • 基因功能參考文獻:
    1. PEAK1's kinase cleft is occluded, and its newly identified SHED region may promote an unexpected dimerization mode. Similarities of PEAK1 with the active kinase PINK1 may reclassify the latter as a member of the new kinase family 3 group. PMID: 29212708
    2. the critical role of the CH region in SgK269/SgK223 association. Importantly, although SgK269 bridged SgK223 to Grb2, it was unable to activate Stat3 or efficiently enhance migration in SgK223 knock-out cells generated by CRISPR/Cas9. PMID: 27531744
    3. Findings indicate that eIF5A-PEAK1-YAP signaling contributes to PDAC development by regulating an STF program associated with increased tumorigenicity. PMID: 28381547
    4. report is the first to provide evidence that PEAK1 mediates signaling cross talk between TGFbeta receptors and integrin/Src/MAPK pathways and that PEAK1 is an important molecular regulator of TGFbeta-induced tumor progression and metastasis in breast cancer PMID: 26267863
    5. this regard, we have demonstrated that PEAK1 is necessary for TGFbeta to induce ZEB1-mediated EMT in the context of fibronectin/ITGB3 activation. PMID: 26297948
    6. Suggest that loss of PEAK1/E-cadherin may play an important role in carcinogenesis and development of gastric cancer through activating epithelial to mesenchymal transition. PMID: 25445115
    7. eIF5A proteins utilize PEAK1 as a downstream effector to drive pancreatic ductal adenocarcinoma (PDAC) pathogenesis. PMID: 25261239
    8. results define a novel signaling pathway in basal breast cancer involving Lyn and SgK269 that offers clinical opportunities for therapeutic intervention PMID: 23378338
    9. phosphorylation of tyrosine 665 in pseudopodium-enriched atypical kinase 1 (PEAK1) is essential for the regulation of cell migration and focal adhesion turnover PMID: 23105102
    10. Here, we report that the novel tyrosine kinase PEAK1 is upregulated in human malignancies, including human PDACs and pancreatic intraepithelial neoplasia (PanIN). PMID: 22589274
    11. Also known as SgK269. Contains a divergent and possibly inactive eukaryotic protein kinase domain. Has one human paralog, known as SgK223 or pragmin. These two constitute the NKF3 subfamily of protein kinases, found in vertebrates and echinoderms PMID: 12471243

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytoskeleton. Cell junction, focal adhesion.
  • 蛋白家族:
    Protein kinase superfamily
  • 數(shù)據(jù)庫鏈接:

    HGNC: 29431

    OMIM: 614248

    KEGG: hsa:79834

    STRING: 9606.ENSP00000309230

    UniGene: Hs.731402



主站蜘蛛池模板: 国产精品99久久免费黑人人妻| 国产jjzzjjzz视频全部免费| 亚洲熟妇久久精品| 精品久久久久久无码专区| 人人妻人人爽人人澡欧美一区| 黄网站成人片免费视频| 4hu四虎永久在线影院| 人妻系列影片无码专区| 特黄三级又爽又粗又大| 66亚洲一卡2卡新区成片发布| 国语精品一区二区三区| 国产无套内射又大又猛又粗又爽| 女人爽到喷水的视频大全| 国产午夜福利在线播放87| 亚州日本乱码一区二区三区| 欧美日韩不卡合集视频| 久久99精品国产麻豆宅宅| 日本丰满白嫩大屁股ass| 曰韩欧美群交p片内射| 精品一区二区三区国产在线观看| 欧美精品一产区二产区| 无码人妻精品中文字幕免费东京热| 国产suv精品一区二区五| 亚洲aⅴ无码国精品中文字慕| 天天狠天天透天干天天| 一本大道大臿蕉视频无码| 激情欧美成人久久综合| 十八18禁国产精品www| 中文字日产幕乱五区| 精品国产免费观看久久久| 人人爽人人爽人人片av亚洲 | 狠狠色丁香婷婷久久综合| 人妻影音先锋啪啪av资源| 国产精品va在线播放| 久久综合给合久久狠狠狠97色| 国产sm主人调教女m视频| 18禁黄网站禁片无遮挡观看 | 国产乱子伦60女人的皮视频| 东京热人妻中文无码av| yy6080久久伦理一区二区| 亚洲国产成av人天堂无码|