在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PEAK1 Antibody

PEAK1 Antibody

  • 中文名稱(chēng)：
    PEAK1兔多克隆抗體
  • 貨號(hào)：
    CSB-PA060164
  • 規(guī)格：
    ￥1090
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    PEAK1
  • 別名：
    FLJ21140 antibody; FLJ34483 antibody; KIAA2002 antibody; NKF3 kinase family member antibody; PEAK1 antibody; PEAK1_HUMAN antibody; pseudopodium enriched atypical kinase antibody; Pseudopodium-enriched atypical kinase 1 antibody; SGK269 antibody; Sugen kinase 269 antibody; Tyrosine-protein kinase SgK269 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human SgK269.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:5000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics. Acts as a scaffold for mediating EGFR signaling.
  • 基因功能參考文獻(xiàn)：
    1. PEAK1's kinase cleft is occluded, and its newly identified SHED region may promote an unexpected dimerization mode. Similarities of PEAK1 with the active kinase PINK1 may reclassify the latter as a member of the new kinase family 3 group. PMID: 29212708
    2. the critical role of the CH region in SgK269/SgK223 association. Importantly, although SgK269 bridged SgK223 to Grb2, it was unable to activate Stat3 or efficiently enhance migration in SgK223 knock-out cells generated by CRISPR/Cas9. PMID: 27531744
    3. Findings indicate that eIF5A-PEAK1-YAP signaling contributes to PDAC development by regulating an STF program associated with increased tumorigenicity. PMID: 28381547
    4. report is the first to provide evidence that PEAK1 mediates signaling cross talk between TGFbeta receptors and integrin/Src/MAPK pathways and that PEAK1 is an important molecular regulator of TGFbeta-induced tumor progression and metastasis in breast cancer PMID: 26267863
    5. this regard, we have demonstrated that PEAK1 is necessary for TGFbeta to induce ZEB1-mediated EMT in the context of fibronectin/ITGB3 activation. PMID: 26297948
    6. Suggest that loss of PEAK1/E-cadherin may play an important role in carcinogenesis and development of gastric cancer through activating epithelial to mesenchymal transition. PMID: 25445115
    7. eIF5A proteins utilize PEAK1 as a downstream effector to drive pancreatic ductal adenocarcinoma (PDAC) pathogenesis. PMID: 25261239
    8. results define a novel signaling pathway in basal breast cancer involving Lyn and SgK269 that offers clinical opportunities for therapeutic intervention PMID: 23378338
    9. phosphorylation of tyrosine 665 in pseudopodium-enriched atypical kinase 1 (PEAK1) is essential for the regulation of cell migration and focal adhesion turnover PMID: 23105102
    10. Here, we report that the novel tyrosine kinase PEAK1 is upregulated in human malignancies, including human PDACs and pancreatic intraepithelial neoplasia (PanIN). PMID: 22589274
    11. Also known as SgK269. Contains a divergent and possibly inactive eukaryotic protein kinase domain. Has one human paralog, known as SgK223 or pragmin. These two constitute the NKF3 subfamily of protein kinases, found in vertebrates and echinoderms PMID: 12471243

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm, cytoskeleton. Cell junction, focal adhesion.
  • 蛋白家族：
    Protein kinase superfamily
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 29431

    OMIM: 614248

    KEGG: hsa:79834

    STRING: 9606.ENSP00000309230

    UniGene: Hs.731402



主站蜘蛛池模板： 蜜桃av色偷偷av老熟女| 九九精品无码专区免费| 亚洲午夜国产精品无码老牛影视| 国产嫖妓风韵犹存对白| 香港特级三a毛片免费观看| 国产精品久久久久久久伊一| 蜜臀av在线观看| h肉动漫无码无修6080动漫网| 国产乱码免费卡1卡二卡3| 久久人午夜亚洲精品无码区| 亚洲肥老太bbw中国熟女| 精品无码无人网站免费视频| 国产区精品系列在线观看| 国产麻豆精品精东影业av网站| 狠狠色噜噜狠狠狠888米奇| 亚洲亚洲人成网站网址| av无码东京热亚洲男人的天堂| 亚洲精品午夜无码电影网| 亚洲午夜福利在线视频| 少女韩国电视剧在线观看完整| 潮喷大喷水系列无码视频| 亚洲午夜精品a片一区二区app| 欧美极品少妇无套实战| 最爽无遮挡行房视频| 2020精品国产午夜福利在线观看| 久久久国产精品麻豆a片| 任你躁x7x7x7x7在线观看| 久久精品国产99国产精2020丨| 亚洲va中文在线播放| 影音先锋中文字幕人妻| 高清无码视频直接看| 成年无码av片在线免缓冲| 国产无遮挡又黄又爽不要vip软件| 久久99热人妻偷产国产| 欧美va免费高清在线观看| 强行征服邻居人妻淑敏| 国产午夜激无码av毛片不卡| 欧美肥熟妇xxxxx| 亚洲成aⅴ人最新无码| 久久久久成人精品| 日躁夜躁狠狠躁2001|