在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NDRG4 Antibody

  • 中文名稱:
    NDRG4兔多克隆抗體
  • 貨號:
    CSB-PA015613GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    NDRG4
  • 別名:
    BDM1 antibody; Brain development-related molecule 1 antibody; KIAA1180 antibody; Ndrg4 antibody; NDRG4_HUMAN antibody; Protein NDRG4 antibody; SMAP 8 antibody; SMAP-8 antibody; Vascular smooth muscle cell-associated protein 8 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human NDRG4
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress. May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner.
  • 基因功能參考文獻:
    1. NDRG4 is exclusively expressed by central, peripheral and enteric neurons/nerves, suggesting a neuronal-specific role of this protein PMID: 28524415
    2. NDRG4 promoter hypermethylation contributed to the risk of gastric cancer and predicted a poor prognosis in Chinese gastric cancer patients. PMID: 28042954
    3. NDRG4 might play an important role during early pregnancy. PMID: 27175791
    4. NDRG4 - the biomarker of a currently in-use multi-target stool DNA test was commonly expressed in tumor tissue specimens, independent of Fecal Immunochemical Test result. PMID: 28044229
    5. Data indicate that patients with tumor of reduced NDRG family member 4 protein (NDRG4) mRNA level had unfavorable disease-free and overall survival. PMID: 26515606
    6. Study shows that NDRG4 was significantly up-regulated in glioblastomas (GBM) and seems to play a role in GBM prognosis. These results indicate that NDRG4 gene in MGMT-methylated cells is a putative tumor-suppressor gene and an oncogene in cells with unmethylated MGMT. PMID: 26976975
    7. These findings bring novel insight to the roles of NDRG4 in meningioma progression PMID: 26053091
    8. A homozygous variant in NDRG4 may be the causative variant of the autosomal recessive form of infantile myofibromatosis. PMID: 25241110
    9. Methylation level in stool decreases dramatically following colorectal cancer resection PMID: 24993691
    10. summarizes the current research on NDRG3 and NDRG4,including the molecular structure, cellular and tissue distribution, biological function, and function in cancer. PMID: 23725756
    11. expression of NDRG4 is downregulated in human gliomas. The glioma patients with lower NDRG4 expression have a poor prognosis. PMID: 22399192
    12. NDRG4 is involved in modulating cell proliferation, invasion, migration and angiogenesis in meningioma, and may play a valuable role as a molecular target in its treatment PMID: 22869042
    13. Over expression of NDRG4 inhibited proliferation of GBM cells. PMID: 22489821
    14. Cloning and expression of the gene; specifically expressed in brain and heart PMID: 11936845
    15. smap8 is involved in the regulation of mitogenic signalling in vascular smooth muscle cells, possibly in response to a homocysteine-induced injury [SMAP8] PMID: 12755708
    16. NDRG4 is a candidate tumor suppressor gene in colorectal cancer whose expression is frequently inactivated by promoter methylation. PMID: 19535783
    17. NDRG4 is required for cell cycle progression and survival, thereby diverging in function from its tumor suppressive family member NDRG2 in astrocytes and GBM cells PMID: 19592488
    18. NDRG4 overexpression enhances ERK activation PMID: 16408304

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytosol.
  • 蛋白家族:
    NDRG family
  • 組織特異性:
    Expressed predominantly in brain and heart (at protein level). In the brain, detected in astrocytes. Isoform 1 and isoform 2 are only expressed in brain. Isoform 3 is expressed in both heart and brain. Up-regulated in glioblastoma multiforme cells.
  • 數據庫鏈接:

    HGNC: 14466

    OMIM: 614463

    KEGG: hsa:65009

    UniGene: Hs.322430



主站蜘蛛池模板: 久久精品国产只有精品2020| 国产播放隔着超薄丝袜进入| 国产成人高清亚洲一区妲妃| 99热在线精品免费全部my| 后入到高潮免费观看| 丰满人妻熟妇乱又伦精品| 久久午夜夜伦鲁鲁片无码免费| 亚洲国产精品尤物yw在线| 欧美影视精品久久| 一区二区和激情视频| 欧美牲交40_50a欧美牲交aⅴ| 99久久久无码国产精品性| 亚洲精品国产嫩草在线观看东京热| 日本欧美一区二区三区在线播放 | 国产精品一区二区在线观看 | 久久国产亚洲精品无码| 人妻av中文字幕久久| 亚洲人成色7777在线观看| 丁香五月婷激情综合第九色| 中文字幕精品久久久久人妻红杏| 精品一卡2卡三卡4卡免费网站| 一个人看的日本hd免费| √最新版天堂资源在线| 一本久久伊人热热精品中文字幕| 伊人久久大香线焦av色| 少妇爆乳无码专区| 国产人成视频在线视频| 亚洲第一无码专区天堂| 欧美亚洲熟妇一区二区三区| 夜夜春夜夜爽| 国内精品人妻无码久久久影院| 成人av久久一区二区三区| 国内精品久久久久影院亚瑟| 99国产精品99久久久久久| 无码色偷偷亚洲国内自拍| 亚洲孰妇无码av在线播放| 国产福利免费视频不卡| 色爽黄1000部免费软件下载| 疯狂做受xxxx高潮欧美日本| 寂寞人妻瑜伽被教练日| 熟妇高潮一区二区三区|