在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NDRG4 Antibody

  • 中文名稱:
    NDRG4兔多克隆抗體
  • 貨號:
    CSB-PA890932LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Western Blot
      Positive WB detected in: A549 whole cell lysate
      All lanes: NDRG4 antibody at 2µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 39, 38, 41, 43, 40 kDa
      Observed band size: 43 kDa
    • Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA890932LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA890932LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA890932LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) NDRG4 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    NDRG4
  • 別名:
    BDM1 antibody; Brain development-related molecule 1 antibody; KIAA1180 antibody; Ndrg4 antibody; NDRG4_HUMAN antibody; Protein NDRG4 antibody; SMAP 8 antibody; SMAP-8 antibody; Vascular smooth muscle cell-associated protein 8 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Protein NDRG4 protein (210-331AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,NDRG4 Antibody (CSB-PA890932LA01HU),的標記方式是Non-conjugated。對于NDRG4 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA890932LB01HU NDRG4 Antibody, HRP conjugated ELISA
    FITC CSB-PA890932LC01HU NDRG4 Antibody, FITC conjugated
    Biotin CSB-PA890932LD01HU NDRG4 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress. May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner.
  • 基因功能參考文獻:
    1. NDRG4 is exclusively expressed by central, peripheral and enteric neurons/nerves, suggesting a neuronal-specific role of this protein PMID: 28524415
    2. NDRG4 promoter hypermethylation contributed to the risk of gastric cancer and predicted a poor prognosis in Chinese gastric cancer patients. PMID: 28042954
    3. NDRG4 might play an important role during early pregnancy. PMID: 27175791
    4. NDRG4 - the biomarker of a currently in-use multi-target stool DNA test was commonly expressed in tumor tissue specimens, independent of Fecal Immunochemical Test result. PMID: 28044229
    5. Data indicate that patients with tumor of reduced NDRG family member 4 protein (NDRG4) mRNA level had unfavorable disease-free and overall survival. PMID: 26515606
    6. Study shows that NDRG4 was significantly up-regulated in glioblastomas (GBM) and seems to play a role in GBM prognosis. These results indicate that NDRG4 gene in MGMT-methylated cells is a putative tumor-suppressor gene and an oncogene in cells with unmethylated MGMT. PMID: 26976975
    7. These findings bring novel insight to the roles of NDRG4 in meningioma progression PMID: 26053091
    8. A homozygous variant in NDRG4 may be the causative variant of the autosomal recessive form of infantile myofibromatosis. PMID: 25241110
    9. Methylation level in stool decreases dramatically following colorectal cancer resection PMID: 24993691
    10. summarizes the current research on NDRG3 and NDRG4,including the molecular structure, cellular and tissue distribution, biological function, and function in cancer. PMID: 23725756
    11. expression of NDRG4 is downregulated in human gliomas. The glioma patients with lower NDRG4 expression have a poor prognosis. PMID: 22399192
    12. NDRG4 is involved in modulating cell proliferation, invasion, migration and angiogenesis in meningioma, and may play a valuable role as a molecular target in its treatment PMID: 22869042
    13. Over expression of NDRG4 inhibited proliferation of GBM cells. PMID: 22489821
    14. Cloning and expression of the gene; specifically expressed in brain and heart PMID: 11936845
    15. smap8 is involved in the regulation of mitogenic signalling in vascular smooth muscle cells, possibly in response to a homocysteine-induced injury [SMAP8] PMID: 12755708
    16. NDRG4 is a candidate tumor suppressor gene in colorectal cancer whose expression is frequently inactivated by promoter methylation. PMID: 19535783
    17. NDRG4 is required for cell cycle progression and survival, thereby diverging in function from its tumor suppressive family member NDRG2 in astrocytes and GBM cells PMID: 19592488
    18. NDRG4 overexpression enhances ERK activation PMID: 16408304

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytosol.
  • 蛋白家族:
    NDRG family
  • 組織特異性:
    Expressed predominantly in brain and heart (at protein level). In the brain, detected in astrocytes. Isoform 1 and isoform 2 are only expressed in brain. Isoform 3 is expressed in both heart and brain. Up-regulated in glioblastoma multiforme cells.
  • 數據庫鏈接:

    HGNC: 14466

    OMIM: 614463

    KEGG: hsa:65009

    UniGene: Hs.322430



主站蜘蛛池模板: 一区二区视频日韩免费| 亚洲日韩国产一区二区三区在线 | 麻豆国产av丝袜白领传媒| 国产三级在线观看免费| 国产网友自拍在线视频| 国产人妻久久精品一区二区三区 | 77se77亚洲欧美在线| 亚洲精品成人av在线| 亚洲一卡一卡二新区迎热烈讨论| 国产性猛交╳xxx乱大交| 亚洲人成影院在线观看| 中国少妇大p毛茸茸| 日日噜噜夜夜狠狠久久无码区| 色翁荡熄又大又硬又粗又视频图片| 国产在线一区二区香蕉 在线| 日本免码va在线看免费| 精品人妻中文字幕有码在线| 国产成人精品亚洲日本在线观看| 欧洲免费一区二区三区视频| 欧美香蕉爽爽人人爽| 亚洲va久久久噜噜噜久久天堂| 国产亚洲精品无码成人| 欧美熟妇性xxx交潮喷| 国产少妇高潮在线观看| 久久精品免视看国产成人明星| 国产二级一片内射视频插放| 亚洲一区二区三区国产精品无码| 人妻av中文字幕一区二区三区 | 国产精品麻豆aⅴ人妻| 人妻精品制服丝袜久久久| 免费观看又色又爽又黄的韩国 | 男女又色又爽又爽视频| 3d动漫精品啪啪一区二区| 国模杨依粉嫩蝴蝶150p| 久久久久国产精品人妻电影| 日本道免费精品一区二区| 国产亚洲精品久久久久久小说| 97精品一区二区视频在线观看| 黑人巨茎美女高潮视频| 2020国产精品午夜福利在线观看| 国产尤物人成免费观看|