在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. NDRG4 Antibody

NDRG4 Antibody

  • 中文名稱：
    NDRG4兔多克隆抗體
  • 貨號：
    CSB-PA238244
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA238244(NDRG4 Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 30 μg, Lane: Mouse heart tissue, Primary antibody: CSB-PA238244(NDRG4 Antibody) at dilution 1/1200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    NDRG4
  • 別名：
    BDM1 antibody; Brain development-related molecule 1 antibody; KIAA1180 antibody; Ndrg4 antibody; NDRG4_HUMAN antibody; Protein NDRG4 antibody; SMAP 8 antibody; SMAP-8 antibody; Vascular smooth muscle cell-associated protein 8 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human NDRG4
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    WB 1:1000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress. May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner.
  • 基因功能參考文獻(xiàn)：
    1. NDRG4 is exclusively expressed by central, peripheral and enteric neurons/nerves, suggesting a neuronal-specific role of this protein PMID: 28524415
    2. NDRG4 promoter hypermethylation contributed to the risk of gastric cancer and predicted a poor prognosis in Chinese gastric cancer patients. PMID: 28042954
    3. NDRG4 might play an important role during early pregnancy. PMID: 27175791
    4. NDRG4 - the biomarker of a currently in-use multi-target stool DNA test was commonly expressed in tumor tissue specimens, independent of Fecal Immunochemical Test result. PMID: 28044229
    5. Data indicate that patients with tumor of reduced NDRG family member 4 protein (NDRG4) mRNA level had unfavorable disease-free and overall survival. PMID: 26515606
    6. Study shows that NDRG4 was significantly up-regulated in glioblastomas (GBM) and seems to play a role in GBM prognosis. These results indicate that NDRG4 gene in MGMT-methylated cells is a putative tumor-suppressor gene and an oncogene in cells with unmethylated MGMT. PMID: 26976975
    7. These findings bring novel insight to the roles of NDRG4 in meningioma progression PMID: 26053091
    8. A homozygous variant in NDRG4 may be the causative variant of the autosomal recessive form of infantile myofibromatosis. PMID: 25241110
    9. Methylation level in stool decreases dramatically following colorectal cancer resection PMID: 24993691
    10. summarizes the current research on NDRG3 and NDRG4,including the molecular structure, cellular and tissue distribution, biological function, and function in cancer. PMID: 23725756
    11. expression of NDRG4 is downregulated in human gliomas. The glioma patients with lower NDRG4 expression have a poor prognosis. PMID: 22399192
    12. NDRG4 is involved in modulating cell proliferation, invasion, migration and angiogenesis in meningioma, and may play a valuable role as a molecular target in its treatment PMID: 22869042
    13. Over expression of NDRG4 inhibited proliferation of GBM cells. PMID: 22489821
    14. Cloning and expression of the gene; specifically expressed in brain and heart PMID: 11936845
    15. smap8 is involved in the regulation of mitogenic signalling in vascular smooth muscle cells, possibly in response to a homocysteine-induced injury [SMAP8] PMID: 12755708
    16. NDRG4 is a candidate tumor suppressor gene in colorectal cancer whose expression is frequently inactivated by promoter methylation. PMID: 19535783
    17. NDRG4 is required for cell cycle progression and survival, thereby diverging in function from its tumor suppressive family member NDRG2 in astrocytes and GBM cells PMID: 19592488
    18. NDRG4 overexpression enhances ERK activation PMID: 16408304

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm, cytosol.
  • 蛋白家族：
    NDRG family
  • 組織特異性：
    Expressed predominantly in brain and heart (at protein level). In the brain, detected in astrocytes. Isoform 1 and isoform 2 are only expressed in brain. Isoform 3 is expressed in both heart and brain. Up-regulated in glioblastoma multiforme cells.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 14466

    OMIM: 614463

    KEGG: hsa:65009

    UniGene: Hs.322430



主站蜘蛛池模板： 国产精品欧美成人片| 精品国产欧美一区二区| 免费观看全黄做爰的视频| 亚洲欧美日韩中文字幕在线一区| 亚洲制服丝中文字幕| 久久久无码精品亚洲日韩啪啪网站| 色婷婷美国农夫综合激情亚洲| 久久久久久久久免费看无码| 日韩人妻无码精品系列| 久久久精品94久久精品| 好吊妞视频这里有精品| 国模小婕私拍鲜嫩玉门| 久久人午夜亚洲精品无码区| 亚洲精品成人av在线| 呦系列视频一区二区三区| 成人视频在线观看| 在线aⅴ亚洲中文字幕| 午夜性色吃奶添下面69影院| 婷婷伊人五月尤物| 精品久久久久久无码人妻热| 久国产精品人妻aⅴ| 男人吃奶摸下挵进去好爽| 小宝极品内射国产在线| 免费又黄又爽1000禁片| 天天看片天天av免费观看| 国产人成午夜免电影费观看| 亚洲日本va午夜中文字幕一区| 不卡无码av一区二区三区| 色综合天天综合欧美综合| 一区二区国产高清视频在线| 欧美一区二区日韩国产| 国产成人免费无庶挡视频| 亚洲六月丁香六月婷婷| 影音先锋人妻啪啪av资源网站| 中文字幕一区二区三区精华液| 人妻少妇精品无码专区芭乐视网| 伊人久久大香线蕉无码| 18禁裸男晨勃露j毛免费观看| 亚洲国产成人久久综合人| 亚洲综合久久一本伊一区| 精品深夜av无码一区二区|