在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NDRG4 Antibody, FITC conjugated

  • 中文名稱:
    NDRG4兔多克隆抗體, FITC偶聯(lián)
  • 貨號:
    CSB-PA890932LC01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) NDRG4 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    NDRG4
  • 別名:
    BDM1 antibody; Brain development-related molecule 1 antibody; KIAA1180 antibody; Ndrg4 antibody; NDRG4_HUMAN antibody; Protein NDRG4 antibody; SMAP 8 antibody; SMAP-8 antibody; Vascular smooth muscle cell-associated protein 8 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Protein NDRG4 protein (210-331AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress. May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner.
  • 基因功能參考文獻:
    1. NDRG4 is exclusively expressed by central, peripheral and enteric neurons/nerves, suggesting a neuronal-specific role of this protein PMID: 28524415
    2. NDRG4 promoter hypermethylation contributed to the risk of gastric cancer and predicted a poor prognosis in Chinese gastric cancer patients. PMID: 28042954
    3. NDRG4 might play an important role during early pregnancy. PMID: 27175791
    4. NDRG4 - the biomarker of a currently in-use multi-target stool DNA test was commonly expressed in tumor tissue specimens, independent of Fecal Immunochemical Test result. PMID: 28044229
    5. Data indicate that patients with tumor of reduced NDRG family member 4 protein (NDRG4) mRNA level had unfavorable disease-free and overall survival. PMID: 26515606
    6. Study shows that NDRG4 was significantly up-regulated in glioblastomas (GBM) and seems to play a role in GBM prognosis. These results indicate that NDRG4 gene in MGMT-methylated cells is a putative tumor-suppressor gene and an oncogene in cells with unmethylated MGMT. PMID: 26976975
    7. These findings bring novel insight to the roles of NDRG4 in meningioma progression PMID: 26053091
    8. A homozygous variant in NDRG4 may be the causative variant of the autosomal recessive form of infantile myofibromatosis. PMID: 25241110
    9. Methylation level in stool decreases dramatically following colorectal cancer resection PMID: 24993691
    10. summarizes the current research on NDRG3 and NDRG4,including the molecular structure, cellular and tissue distribution, biological function, and function in cancer. PMID: 23725756
    11. expression of NDRG4 is downregulated in human gliomas. The glioma patients with lower NDRG4 expression have a poor prognosis. PMID: 22399192
    12. NDRG4 is involved in modulating cell proliferation, invasion, migration and angiogenesis in meningioma, and may play a valuable role as a molecular target in its treatment PMID: 22869042
    13. Over expression of NDRG4 inhibited proliferation of GBM cells. PMID: 22489821
    14. Cloning and expression of the gene; specifically expressed in brain and heart PMID: 11936845
    15. smap8 is involved in the regulation of mitogenic signalling in vascular smooth muscle cells, possibly in response to a homocysteine-induced injury [SMAP8] PMID: 12755708
    16. NDRG4 is a candidate tumor suppressor gene in colorectal cancer whose expression is frequently inactivated by promoter methylation. PMID: 19535783
    17. NDRG4 is required for cell cycle progression and survival, thereby diverging in function from its tumor suppressive family member NDRG2 in astrocytes and GBM cells PMID: 19592488
    18. NDRG4 overexpression enhances ERK activation PMID: 16408304

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytosol.
  • 蛋白家族:
    NDRG family
  • 組織特異性:
    Expressed predominantly in brain and heart (at protein level). In the brain, detected in astrocytes. Isoform 1 and isoform 2 are only expressed in brain. Isoform 3 is expressed in both heart and brain. Up-regulated in glioblastoma multiforme cells.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 14466

    OMIM: 614463

    KEGG: hsa:65009

    UniGene: Hs.322430



主站蜘蛛池模板: 亚洲国产日韩a在线播放| 丰满人妻妇伦又伦精品国产| 99精品偷自拍| 中文www新版资源在线| 在线综合亚洲欧美网站| 国色天香网www在线观看| 在线天堂资源www| 亚洲精品久久久久中文字幕| 大乳丰满人妻中文字幕日本| av中文字幕潮喷人妻系列| 伊人色综合久久天天网| 亚洲精品无码久久久久av麻豆 | 欧美日本国产va高清cabal| 两个人日本www免费版| 日本视频免费高清一本18| 久久一卡二卡三卡四卡| 国产内射老熟女aaaa| 动漫av纯肉无码av在线播放| 色妞精品av一区二区三区| av不卡国产在线观看| 色诱久久久久综合网ywww| 丁香五月欧美成人| 免费无遮挡无码视频网站| av影音先锋最大资源网| 国产区精品福利在线社区| 青青草国产成人99久久| 国产午夜理论片不卡| 啪啪激情婷婷久久婷婷色五月| 成 人 网 站 免费观看| 无码国内精品人妻少妇蜜桃视频 | 久久97国产超碰青草| 国语自产拍在线观看对白| 人与嘼av免费| 午夜久久久久久禁播电影| 亚洲人成网站在线播放小说 | 久久久久久人妻精品一区| 亚洲熟妇色自偷自拍另类| 久久av无码aⅴ高潮av喷吹| 一本无码中文字幕在线观| 中文字幕精品一区二区2021年| 在线视频免费观看爽爽爽|