在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NBR1 Antibody

  • 中文名稱:
    NBR1兔多克隆抗體
  • 貨號(hào):
    CSB-PA015508GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    1A1 3B antibody; 1A13B antibody; B box protein antibody; Cell migration-inducing gene 19 protein antibody; KIAA0049 antibody; M17S2 antibody; Membrane component chromosome 17 surface marker 2 antibody; Membrane component, chromosome 17, surface marker 2 (ovarian carcinoma antigen CA125) antibody; MIG 19 antibody; MIG19 antibody; Migration inducing protein 19 antibody; NBR 1 antibody; Nbr1 antibody; NBR1, autophagy cargo receptor antibody; NBR1_HUMAN antibody; Neighbor of BRCA1 gene 1 antibody; Neighbor of BRCA1 gene 1 protein antibody; Next to BRCA1 gene 1 protein antibody; Ovarian carcinoma antigen CA125 antibody; Protein 1A1-3B antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human NBR1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB,IF
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.
  • 基因功能參考文獻(xiàn):
    1. NBR1 is not required for PARK2-dependent mitophagy. PMID: 26512954
    2. The NBR1 depletion impairs FA turnover and decreases targeting of autophagosomes to FAs, whereas ectopic expression of autophagy-competent, but not autophagy-defective, NBR1 enhances FA disassembly and reduces FA lifetime during migration. PMID: 26903539
    3. NBR1 positively correlates with adipose inflammation in human obese patients. PMID: 25043814
    4. Analysis of muscle biopsies of sporadic inclusion body myositis (sIBM) patients revealed a strong decrease of NBR1 phosphorylation in muscles of sIBM patients that directly correlated with the severity of protein aggregation. PMID: 24879152
    5. The C-terminal fragments of SQSTM1 and NBR1 exhibited a dominant-negative effect against native SQSTM1/NBR1, probably by competing for LC3 and ubiquitin chain binding. PMID: 24769734
    6. structure of the ubiquitin-associated (UBA) domain of human autophagy receptor NBR1 and its interaction with ubiquitin and polyubiquitin PMID: 24692539
    7. results suggest that NBR1 is the specific autophagy receptor for pexophagy. PMID: 23239026
    8. These findings suggest that NBR1 is involved in the formation of cytoplasmic inclusions in alpha-synucleinopathy. PMID: 22484440
    9. The structural ensemble representing each of the two sequential folding transition transition states of the PB1 domain of NBR1 has been calculated using experimental Phi values and biased molecular dynamics simulations. PMID: 21121670
    10. Autophagy-related NBR1 protein is not involved in the formation/degradation of neuronal intranuclear inclusions in neurodegenerative diseases. PMID: 22728060
    11. Breast and ovarian cancer risk are high in Jewish women with BRCA1 genetic mutation. PMID: 22430266
    12. AtNBR1 is more similar to mammalian NBR1 than to p62 in domain architecture and amino acid sequence. PMID: 21606687
    13. Results indicate that the presence of a tryptophan residue in the LIR motif increases the binding affinity of GABARAPL-1/NBR1-LIR complex. PMID: 21620860
    14. interacts with two proteins; fasciculation and elongation protein zeta-1 (FEZ1), a PKCzeta interacting protein, and calcium and integrin binding protein (CIB), also shows developmentally restricted expression in the neural tube PMID: 11856312
    15. NBR1 together with p62 promotes autophagic degradation of ubiquitinated targets and simultaneously regulates their aggregation when autophagy becomes limited. PMID: 19398892
    16. The nbr1 UBA domain binds to lysine-48 and -63 linked polyubiquitin-B chains. Nbr1 also binds to the autophagic effector protein LC3-A via a novel binding site. PMID: 19427866
    17. findings suggest a critical function for NBR1 in the regulation of receptor trafficking and provide a mechanism for down-regulation of signaling by Spred2 via NBR1. PMID: 19822672

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm. Cytoplasmic vesicle, autophagosome. Lysosome. Cytoplasm, myofibril, sarcomere, M line.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 6746

    OMIM: 166945

    KEGG: hsa:4077

    STRING: 9606.ENSP00000343479

    UniGene: Hs.277721



主站蜘蛛池模板: 男女啪啪抽搐呻吟高潮动态图| 亚洲色成人网一二三区| 国产精品无码免费播放| 欧美性猛交xxxx免费看| 国产成人精品自在线导航| 9l国产精品久久久久麻豆| 国产肥熟女视频一区二区三区| 美女av一区二区三区| 久久精品av麻豆| 久久久国产精品无码一区二区| 亚洲风影视传媒有限公司辽宁| 免费观看亚洲人成网站| 自愉自愉产区二十四区| 午夜片无码区在线观看视频| 51福利国产在线观看午夜天堂| 日产精品久久久久久久| 国产亚洲精品一区二区三区| 久久/这里只精品热在线获取| 久久婷婷六月综合色液啪| 亚洲天天做日日做天天欢毛片 | 先锋影音最新色资源站| 日本五月天婷久久网站| 香蕉97超级碰碰碰免费公开| 亚洲人成伊人成综合网久久久| 无码av免费一区二区三区| 国产av麻豆mag剧集| 精品国产经典三级在线看| 久久精品高清一区二区三区| 特级做a爰片毛片免费看108| 亚洲a∨国产av综合av| 成人美女黄网站色大色费全看 | 孕妇怀孕高潮潮喷视频孕妇 | 18勿入网站免费永久| 国产v在线在线观看视频免费 | 国产精品99久久久久久董美香| 久久99精品久久久久久| 亚洲自偷自偷在线成人网址| 乱人伦视频中文字幕| 色在线亚洲视频www| 5d肉蒲团之性战奶水| 亚洲乱亚洲乱妇24p|