在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NBR1 Antibody

  • 中文名稱:
    NBR1兔多克隆抗體
  • 貨號:
    CSB-PA514397
  • 規(guī)格:
    ¥1090
  • 圖片:
    • Immunohistochemical analysis of paraffin-embedded Human Skeletal Muslce Tissue using NBR1 Rabbit pAb diluted at 1:200
    • Immunohistochemical analysis of paraffin-embedded Human Breast Carcinoma Tissue using NBR1 Rabbit pAb diluted at 1:200
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    1A1 3B antibody; 1A13B antibody; B box protein antibody; Cell migration-inducing gene 19 protein antibody; KIAA0049 antibody; M17S2 antibody; Membrane component chromosome 17 surface marker 2 antibody; Membrane component, chromosome 17, surface marker 2 (ovarian carcinoma antigen CA125) antibody; MIG 19 antibody; MIG19 antibody; Migration inducing protein 19 antibody; NBR 1 antibody; Nbr1 antibody; NBR1, autophagy cargo receptor antibody; NBR1_HUMAN antibody; Neighbor of BRCA1 gene 1 antibody; Neighbor of BRCA1 gene 1 protein antibody; Next to BRCA1 gene 1 protein antibody; Ovarian carcinoma antigen CA125 antibody; Protein 1A1-3B antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Recombinant Protein
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 純化方式:
    The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:50-1:200
    ELISA 1:10000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.
  • 基因功能參考文獻:
    1. NBR1 is not required for PARK2-dependent mitophagy. PMID: 26512954
    2. The NBR1 depletion impairs FA turnover and decreases targeting of autophagosomes to FAs, whereas ectopic expression of autophagy-competent, but not autophagy-defective, NBR1 enhances FA disassembly and reduces FA lifetime during migration. PMID: 26903539
    3. NBR1 positively correlates with adipose inflammation in human obese patients. PMID: 25043814
    4. Analysis of muscle biopsies of sporadic inclusion body myositis (sIBM) patients revealed a strong decrease of NBR1 phosphorylation in muscles of sIBM patients that directly correlated with the severity of protein aggregation. PMID: 24879152
    5. The C-terminal fragments of SQSTM1 and NBR1 exhibited a dominant-negative effect against native SQSTM1/NBR1, probably by competing for LC3 and ubiquitin chain binding. PMID: 24769734
    6. structure of the ubiquitin-associated (UBA) domain of human autophagy receptor NBR1 and its interaction with ubiquitin and polyubiquitin PMID: 24692539
    7. results suggest that NBR1 is the specific autophagy receptor for pexophagy. PMID: 23239026
    8. These findings suggest that NBR1 is involved in the formation of cytoplasmic inclusions in alpha-synucleinopathy. PMID: 22484440
    9. The structural ensemble representing each of the two sequential folding transition transition states of the PB1 domain of NBR1 has been calculated using experimental Phi values and biased molecular dynamics simulations. PMID: 21121670
    10. Autophagy-related NBR1 protein is not involved in the formation/degradation of neuronal intranuclear inclusions in neurodegenerative diseases. PMID: 22728060
    11. Breast and ovarian cancer risk are high in Jewish women with BRCA1 genetic mutation. PMID: 22430266
    12. AtNBR1 is more similar to mammalian NBR1 than to p62 in domain architecture and amino acid sequence. PMID: 21606687
    13. Results indicate that the presence of a tryptophan residue in the LIR motif increases the binding affinity of GABARAPL-1/NBR1-LIR complex. PMID: 21620860
    14. interacts with two proteins; fasciculation and elongation protein zeta-1 (FEZ1), a PKCzeta interacting protein, and calcium and integrin binding protein (CIB), also shows developmentally restricted expression in the neural tube PMID: 11856312
    15. NBR1 together with p62 promotes autophagic degradation of ubiquitinated targets and simultaneously regulates their aggregation when autophagy becomes limited. PMID: 19398892
    16. The nbr1 UBA domain binds to lysine-48 and -63 linked polyubiquitin-B chains. Nbr1 also binds to the autophagic effector protein LC3-A via a novel binding site. PMID: 19427866
    17. findings suggest a critical function for NBR1 in the regulation of receptor trafficking and provide a mechanism for down-regulation of signaling by Spred2 via NBR1. PMID: 19822672

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Cytoplasmic vesicle, autophagosome. Lysosome. Cytoplasm, myofibril, sarcomere, M line.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 6746

    OMIM: 166945

    KEGG: hsa:4077

    STRING: 9606.ENSP00000343479

    UniGene: Hs.277721



主站蜘蛛池模板: 日本新janpanese乱熟| 欧美顶级少妇做爰hd| 伊人亚洲大杳蕉色无码| 亚洲色成人网一二三区 | 亚洲色大成网站在线| 久久久久人妻精品区一三寸| 国产老熟妇精品观看| 午夜精品久久久久久毛片| 风流少妇按摩来高潮| 亚洲精品综合在线影院| 日韩欧美mv在线观看免费| 狠狠色噜噜狠狠狠7777奇米| 国内揄拍国产精品人妻门事件| 久久久精品2019免费观看| 99精品国产一区二区三区a片| 国产成人av一区二区三区| 中文字幕v亚洲ⅴv天堂| 欧美成aⅴ人高清免费| 国产精品自在拍首页视频| 天美传媒一区二区| 无码av天天av天天爽| 亚洲欧美v国产蜜芽tv| 亚洲欧美另类精品二区| 日韩人妻无码一区二区三区| 亚洲不卡av不卡一区二区| 亚洲精品入口一区二区乱麻豆精品 | 久久无码专区国产精品| 中文字幕av一区二区三区人妻少妇 | 天天躁久久躁日日躁| 加勒比色综合久久久久久久久| 免费国精产品自偷自偷免费看| 青青草国产精品一区二区| 精品伊人久久久大香线蕉下载 | 日韩不卡1卡2卡三卡2021免费| 国产男女猛烈无遮挡免费网站| 精品国产麻豆免费人成网站| 在线 国产 精品 蜜芽| 亚洲人成网站色www| av片在线观看免费| 久久婷婷人人澡人人爽人人喊| 色久悠悠婷婷综合在线亚洲|