在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NBR1 Antibody

  • 中文名稱:
    NBR1兔多克隆抗體
  • 貨號:
    CSB-PA622775ESR1HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA622775ESR1HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) NBR1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    1A1 3B antibody; 1A13B antibody; B box protein antibody; Cell migration-inducing gene 19 protein antibody; KIAA0049 antibody; M17S2 antibody; Membrane component chromosome 17 surface marker 2 antibody; Membrane component, chromosome 17, surface marker 2 (ovarian carcinoma antigen CA125) antibody; MIG 19 antibody; MIG19 antibody; Migration inducing protein 19 antibody; NBR 1 antibody; Nbr1 antibody; NBR1, autophagy cargo receptor antibody; NBR1_HUMAN antibody; Neighbor of BRCA1 gene 1 antibody; Neighbor of BRCA1 gene 1 protein antibody; Next to BRCA1 gene 1 protein antibody; Ovarian carcinoma antigen CA125 antibody; Protein 1A1-3B antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Next to BRCA1 gene 1 protein (1-280AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.
  • 基因功能參考文獻:
    1. NBR1 is not required for PARK2-dependent mitophagy. PMID: 26512954
    2. The NBR1 depletion impairs FA turnover and decreases targeting of autophagosomes to FAs, whereas ectopic expression of autophagy-competent, but not autophagy-defective, NBR1 enhances FA disassembly and reduces FA lifetime during migration. PMID: 26903539
    3. NBR1 positively correlates with adipose inflammation in human obese patients. PMID: 25043814
    4. Analysis of muscle biopsies of sporadic inclusion body myositis (sIBM) patients revealed a strong decrease of NBR1 phosphorylation in muscles of sIBM patients that directly correlated with the severity of protein aggregation. PMID: 24879152
    5. The C-terminal fragments of SQSTM1 and NBR1 exhibited a dominant-negative effect against native SQSTM1/NBR1, probably by competing for LC3 and ubiquitin chain binding. PMID: 24769734
    6. structure of the ubiquitin-associated (UBA) domain of human autophagy receptor NBR1 and its interaction with ubiquitin and polyubiquitin PMID: 24692539
    7. results suggest that NBR1 is the specific autophagy receptor for pexophagy. PMID: 23239026
    8. These findings suggest that NBR1 is involved in the formation of cytoplasmic inclusions in alpha-synucleinopathy. PMID: 22484440
    9. The structural ensemble representing each of the two sequential folding transition transition states of the PB1 domain of NBR1 has been calculated using experimental Phi values and biased molecular dynamics simulations. PMID: 21121670
    10. Autophagy-related NBR1 protein is not involved in the formation/degradation of neuronal intranuclear inclusions in neurodegenerative diseases. PMID: 22728060
    11. Breast and ovarian cancer risk are high in Jewish women with BRCA1 genetic mutation. PMID: 22430266
    12. AtNBR1 is more similar to mammalian NBR1 than to p62 in domain architecture and amino acid sequence. PMID: 21606687
    13. Results indicate that the presence of a tryptophan residue in the LIR motif increases the binding affinity of GABARAPL-1/NBR1-LIR complex. PMID: 21620860
    14. interacts with two proteins; fasciculation and elongation protein zeta-1 (FEZ1), a PKCzeta interacting protein, and calcium and integrin binding protein (CIB), also shows developmentally restricted expression in the neural tube PMID: 11856312
    15. NBR1 together with p62 promotes autophagic degradation of ubiquitinated targets and simultaneously regulates their aggregation when autophagy becomes limited. PMID: 19398892
    16. The nbr1 UBA domain binds to lysine-48 and -63 linked polyubiquitin-B chains. Nbr1 also binds to the autophagic effector protein LC3-A via a novel binding site. PMID: 19427866
    17. findings suggest a critical function for NBR1 in the regulation of receptor trafficking and provide a mechanism for down-regulation of signaling by Spred2 via NBR1. PMID: 19822672

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Cytoplasmic vesicle, autophagosome. Lysosome. Cytoplasm, myofibril, sarcomere, M line.
  • 數據庫鏈接:

    HGNC: 6746

    OMIM: 166945

    KEGG: hsa:4077

    STRING: 9606.ENSP00000343479

    UniGene: Hs.277721



主站蜘蛛池模板: 国产精品卡一卡二卡三| 中文无码乱人伦中文视频在线| 国产精品久久国产精品99 gif| 久久久久人妻一区二区三区vr| 日日摸天天摸人人看| 日本特黄aaaaaa大片| 久久精品国产亚洲7777| 小箩莉末发育娇小性色xxxx| 无码超乳爆乳中文字幕久久| 亚洲卡一卡二新区| 中文字幕精品亚洲无线码一区| 中文字幕精品无码一区二区| av无码一区二区二三区1区6区| 婷婷丁香五月亚洲中文字幕| 久久精品国产欧美日韩 | av综合网男人的天堂| 波多野结衣乳巨码无在线| 狠狠躁夜夜躁人人爽天天5| 1000部又爽又黄无遮挡的视频| 美女扒开腿让男人桶爽揉| 国产成人av一区二区在线观看| 天堂资源在线www中文| 欧美亚洲日本国产综合在线| 国模小黎自慰337p人体| 国内女人喷潮完整视频| 寂寞骚妇被后入式爆草抓爆| 亚洲日本中文字幕乱码在线| 欧美毛多水多肥妇| 全球av集中精品导航福利| 天堂最新版资源网| 97免费人妻在线视频| 精品人妻午夜一区二区三区四区| 色综合色欲色综合色综合色综合r| 国产99视频精品免费视频6| 狠狠色狠狠色综合网| 亚洲国产精品国自产拍av| 97人妻无码专区| 99久久99久久免费精品蜜桃| 亚洲欧美色一区二区三区| 日韩卡1卡2 卡三卡免费| 萝卜视频高清免费视频日本 |