在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NBR1 Antibody

  • 中文名稱:
    NBR1兔多克隆抗體
  • 貨號:
    CSB-PA286085
  • 規格:
    ¥1090
  • 圖片:
    • Immunohistochemical analysis of paraffin-embedded Human Skeletal Muslce Tissue using NBR1 Rabbit pAb diluted at 1:500
    • Immunohistochemical analysis of paraffin-embedded Human Breast Carcinoma Tissue using NBR1 Rabbit pAb diluted at 1:500
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    1A1 3B antibody; 1A13B antibody; B box protein antibody; Cell migration-inducing gene 19 protein antibody; KIAA0049 antibody; M17S2 antibody; Membrane component chromosome 17 surface marker 2 antibody; Membrane component, chromosome 17, surface marker 2 (ovarian carcinoma antigen CA125) antibody; MIG 19 antibody; MIG19 antibody; Migration inducing protein 19 antibody; NBR 1 antibody; Nbr1 antibody; NBR1, autophagy cargo receptor antibody; NBR1_HUMAN antibody; Neighbor of BRCA1 gene 1 antibody; Neighbor of BRCA1 gene 1 protein antibody; Next to BRCA1 gene 1 protein antibody; Ovarian carcinoma antigen CA125 antibody; Protein 1A1-3B antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Recombinant Protein
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 純化方式:
    The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:50-1:200
    ELISA 1:10000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.
  • 基因功能參考文獻:
    1. NBR1 is not required for PARK2-dependent mitophagy. PMID: 26512954
    2. The NBR1 depletion impairs FA turnover and decreases targeting of autophagosomes to FAs, whereas ectopic expression of autophagy-competent, but not autophagy-defective, NBR1 enhances FA disassembly and reduces FA lifetime during migration. PMID: 26903539
    3. NBR1 positively correlates with adipose inflammation in human obese patients. PMID: 25043814
    4. Analysis of muscle biopsies of sporadic inclusion body myositis (sIBM) patients revealed a strong decrease of NBR1 phosphorylation in muscles of sIBM patients that directly correlated with the severity of protein aggregation. PMID: 24879152
    5. The C-terminal fragments of SQSTM1 and NBR1 exhibited a dominant-negative effect against native SQSTM1/NBR1, probably by competing for LC3 and ubiquitin chain binding. PMID: 24769734
    6. structure of the ubiquitin-associated (UBA) domain of human autophagy receptor NBR1 and its interaction with ubiquitin and polyubiquitin PMID: 24692539
    7. results suggest that NBR1 is the specific autophagy receptor for pexophagy. PMID: 23239026
    8. These findings suggest that NBR1 is involved in the formation of cytoplasmic inclusions in alpha-synucleinopathy. PMID: 22484440
    9. The structural ensemble representing each of the two sequential folding transition transition states of the PB1 domain of NBR1 has been calculated using experimental Phi values and biased molecular dynamics simulations. PMID: 21121670
    10. Autophagy-related NBR1 protein is not involved in the formation/degradation of neuronal intranuclear inclusions in neurodegenerative diseases. PMID: 22728060
    11. Breast and ovarian cancer risk are high in Jewish women with BRCA1 genetic mutation. PMID: 22430266
    12. AtNBR1 is more similar to mammalian NBR1 than to p62 in domain architecture and amino acid sequence. PMID: 21606687
    13. Results indicate that the presence of a tryptophan residue in the LIR motif increases the binding affinity of GABARAPL-1/NBR1-LIR complex. PMID: 21620860
    14. interacts with two proteins; fasciculation and elongation protein zeta-1 (FEZ1), a PKCzeta interacting protein, and calcium and integrin binding protein (CIB), also shows developmentally restricted expression in the neural tube PMID: 11856312
    15. NBR1 together with p62 promotes autophagic degradation of ubiquitinated targets and simultaneously regulates their aggregation when autophagy becomes limited. PMID: 19398892
    16. The nbr1 UBA domain binds to lysine-48 and -63 linked polyubiquitin-B chains. Nbr1 also binds to the autophagic effector protein LC3-A via a novel binding site. PMID: 19427866
    17. findings suggest a critical function for NBR1 in the regulation of receptor trafficking and provide a mechanism for down-regulation of signaling by Spred2 via NBR1. PMID: 19822672

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Cytoplasmic vesicle, autophagosome. Lysosome. Cytoplasm, myofibril, sarcomere, M line.
  • 數據庫鏈接:

    HGNC: 6746

    OMIM: 166945

    KEGG: hsa:4077

    STRING: 9606.ENSP00000343479

    UniGene: Hs.277721



主站蜘蛛池模板: 伊人久久大香线蕉av五月天宝贝| 国产精品嫩草影院免费观看| 亚洲精品无码少妇30p| 国产成人小说视频在线观看| 国产特级毛片aaaaaa高清| 天堂√最新版中文在线地址| 亚洲中文字幕丝祙制服| 国产乱人伦av在线麻豆a| 国产精品无码午夜福利| 精品久久久久久成人av| 国产真实自在自线免费精品| 久久理论片午夜琪琪电影网| 国产精品人人做人人爽| 在线精品一区二区三区| 中国熟妇毛多多裸交视频| a在线观看免费网站大全| 国产卡一卡二卡三无线乱码新区| 色偷偷av一区二区三区| 欧美做受视频播放| av无码精品一区二区三区四区 | 一区二区三区在线 | 网站| 久久综合给合久久狠狠狠88| 无码人妻久久一区二区三区app| 久久久久久av无码免费看大片| 狠狠色丁香久久婷婷综合图片| 狠狠躁夜夜躁无码中文字幕| 国产精品人妻久久久久| 尤物永久网站| 久久久这里只有精品10| 国产综合18久久久久久| 无码人妻aⅴ一区二区三区| 亚洲中文字幕精品久久| 777米奇影院狠狠色| 豆国产95在线 | 亚洲| 国产suv精品一区二人妻| 日韩卡二卡三卡四卡永久入口| 久久97精品久久久久久久不卡| 欧美最猛性xxxxx免费| 极品无码av国模在线观看 | 疯狂三人交性欧美| 水蜜桃av无码|