在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MTBP Antibody

MTBP Antibody

  • 中文名稱：
    MTBP兔多克隆抗體
  • 貨號：
    CSB-PA856921LA01HU
  • 規格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA856921LA01HU diluted at 1:400 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) MTBP Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MTBP
  • 別名：
    hMTBP antibody; MDM 2 binding protein antibody; MDM 2 BP antibody; MDM2 (mouse double minute 2) binding protein 104kD antibody; MDM2 (mouse double minute 2) binding protein antibody; MDM2 binding protein antibody; MDM2 BP antibody; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein 104kDa antibody; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein antibody; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein binding protein antibody; Mdm2-binding protein antibody; MDM2BP antibody; Mouse double minute 2 homolog binding protein antibody; MTBP antibody; MTBP_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Mdm2-binding protein (567-724AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，MTBP Antibody (CSB-PA856921LA01HU)，的標記方式是Non-conjugated。對于MTBP Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA856921LB01HU MTBP Antibody, HRP conjugated ELISA
    FITC CSB-PA856921LC01HU MTBP Antibody, FITC conjugated
    Biotin CSB-PA856921LD01HU MTBP Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells. May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation.
  • 基因功能參考文獻：
    1. data show that MTBP aggravates the invasion and metastasis of HCC by promoting the MDM2-mediated degradation of E-cadherin. PMID: 26280083
    2. Overexpression of MTBP resulted in the suppression of the migratory and metastatic potential of Hepatocellular carcinoma cells, while its downregulation increased the migration. PMID: 25759210
    3. MTBP significantly contributes to breast cancer survival and is a potential novel therapeutic target in Triple-negative breast cancer . PMID: 24866769
    4. MTBP associated with MYC at promoters and increased MYC-mediated transcription, proliferation, neoplastic transformation, and tumor development. PMID: 24786788
    5. MTBP acts with Treslin/TICRR to integrate signals from cell cycle and DNA damage response pathways to control the initiation of DNA replication in human cells. PMID: 23704573
    6. MTBP also inhibited ACTN4-mediated F-actin bundling. PMID: 22370640
    7. identification and characterization of mouse Mdm2 binding protein PMID: 10906133
    8. MTBP has an important role in recruiting and/or retaining the Mad1/Mad2 complex at the kinetochores during prometaphase, but its degradation is required for silencing the mitotic checkpoint. PMID: 21274008
    9. results represent the first examination of MTBP expression in human tissues and provide evidence for a p53 status-dependent role for MTBP in suppressing disease progression in squamous cell carcinoma of the head and neck patients PMID: 21692053
    10. Data suggest that MTBP differentially regulates the activity of MDM2 towards two of its most critical targets (itself and p53) and in doing so significantly contributes to MDM2-dependent p53 homeostasis in unstressed cells. PMID: 15632057
    11. MTBP contributes to MDM2 activity and through this to negative regulation of p53 PMID: 15632057

    顯示更多

    收起更多

  • 蛋白家族：
    MTBP family
  • 數據庫鏈接：

    HGNC: 7417

    OMIM: 605927

    KEGG: hsa:27085

    STRING: 9606.ENSP00000303398

    UniGene: Hs.657656



主站蜘蛛池模板： 老子午夜精品无码不卡| 精品人妻va出轨中文字幕| 色狠狠av老熟女| 国产区图片区小说区亚洲区| 巨大黑人极品videos精品| 日韩av在线观看免费| 国产原创av中文在线观看| 成人精品一区二区三区在线观看 | 亚洲熟妇无码一区二区三区| 日韩成人无码一区二区三区| 亚洲aⅴ无码国精品中文字慕| 天堂va欧美va亚洲va好看va| 日本动漫瀑乳h动漫啪啪免费 | 国产亚洲日韩一区二区三区| 一本大道伊人av久久综合| 99久久精品国产一区二区蜜芽| 少妇高潮喷水在线观看| 久久久久99精品成人品| 粗大的内捧猛烈进出视频| 欧美男生射精高潮视频网站| 永久免费无码成人网站| 乱码精品一区二区三区| 国产麻无矿码直接观看| 麻豆精产国品| 久久九九精品国产综合喷水| 在线亚洲中文精品第1页| 上司人妻互换中文字幕| 亚洲爆乳无码一区二区三区| 在教室伦流澡到高潮hgl动漫| 亚洲精品午夜久久久伊人| 无套内谢孕妇毛片免费看看| 特级无码毛片免费视频尤物| 免费va人成视频网站全| 欧美中日韩免费观看网站| 精品一区二区不卡无码av| 少妇人妻上班偷人精品视频| 久久久久人妻一区视色| 真实国产乱啪福利露脸| 精品视频无码一区二区三区| 在线观看国产午夜福利片| 在教室伦流澡到高潮hgl视频|