在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MTBP Antibody, FITC conjugated

MTBP Antibody, FITC conjugated

  • 中文名稱：
    MTBP兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA856921LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) MTBP Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MTBP
  • 別名：
    hMTBP antibody; MDM 2 binding protein antibody; MDM 2 BP antibody; MDM2 (mouse double minute 2) binding protein 104kD antibody; MDM2 (mouse double minute 2) binding protein antibody; MDM2 binding protein antibody; MDM2 BP antibody; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein 104kDa antibody; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein antibody; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein binding protein antibody; Mdm2-binding protein antibody; MDM2BP antibody; Mouse double minute 2 homolog binding protein antibody; MTBP antibody; MTBP_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Mdm2-binding protein (567-724AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells. May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation.
  • 基因功能參考文獻：
    1. data show that MTBP aggravates the invasion and metastasis of HCC by promoting the MDM2-mediated degradation of E-cadherin. PMID: 26280083
    2. Overexpression of MTBP resulted in the suppression of the migratory and metastatic potential of Hepatocellular carcinoma cells, while its downregulation increased the migration. PMID: 25759210
    3. MTBP significantly contributes to breast cancer survival and is a potential novel therapeutic target in Triple-negative breast cancer . PMID: 24866769
    4. MTBP associated with MYC at promoters and increased MYC-mediated transcription, proliferation, neoplastic transformation, and tumor development. PMID: 24786788
    5. MTBP acts with Treslin/TICRR to integrate signals from cell cycle and DNA damage response pathways to control the initiation of DNA replication in human cells. PMID: 23704573
    6. MTBP also inhibited ACTN4-mediated F-actin bundling. PMID: 22370640
    7. identification and characterization of mouse Mdm2 binding protein PMID: 10906133
    8. MTBP has an important role in recruiting and/or retaining the Mad1/Mad2 complex at the kinetochores during prometaphase, but its degradation is required for silencing the mitotic checkpoint. PMID: 21274008
    9. results represent the first examination of MTBP expression in human tissues and provide evidence for a p53 status-dependent role for MTBP in suppressing disease progression in squamous cell carcinoma of the head and neck patients PMID: 21692053
    10. Data suggest that MTBP differentially regulates the activity of MDM2 towards two of its most critical targets (itself and p53) and in doing so significantly contributes to MDM2-dependent p53 homeostasis in unstressed cells. PMID: 15632057
    11. MTBP contributes to MDM2 activity and through this to negative regulation of p53 PMID: 15632057

    顯示更多

    收起更多

  • 蛋白家族：
    MTBP family
  • 數據庫鏈接：

    HGNC: 7417

    OMIM: 605927

    KEGG: hsa:27085

    STRING: 9606.ENSP00000303398

    UniGene: Hs.657656



主站蜘蛛池模板： 色欲久久人妻内射| 久久精品无码一区二区三区免费| 日韩人妻中文无码一区二区三区| 人妻av中文系列| 九九热在线视频观看这里只有精品| 最新系列国产专区|亚洲国产| 亚洲综合无码av一区二区三区| 亚洲精品少妇一区二区| 影音先锋亚洲成aⅴ人在| 国产无遮挡无码视频免费软件| 99精品国产福利在线观看| 亚洲欧美中文高清在线专区 | 一边添奶一边添p好爽视频| 综合图片亚洲综合网站| 久久综合给合久久国产免费| 久久午夜无码鲁丝片直播午夜精品| 欧洲av无码放荡人妇网站| 无码精品视频一区二区三区| 国产无遮挡裸体免费视频| 午夜伦yy44880影院| 久久精品亚洲精品无码白云tv| 中国免费看的片| 在线视频免费观看爽爽爽| 亚洲中文字幕无码久久2020| 欧美白人最猛性xxxxx| 亚洲天天做日日做天天谢日日欢| 国产无线乱码一区二三区| 无码不卡中文字幕av| 一区二三区在线 | 中国| 无码人妻人妻经典| 狠狠色综合网久久久久久| 亚洲日韩欧美国产另类综合| 亚洲影院丰满少妇中文字幕无码| 麻花传媒在线mv免费观看视频| 亚洲日本中文字幕天天更新| 久久综合精品国产一区二区三区无码| 中文字幕在线影视| 久久亚洲中文字幕无码| 7777精品久久久大香线蕉| 人妻精品久久无码区| 人禽伦免费交视频播放|