在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Mdm2-binding protein (MTBP), partial

  • 中文名稱:
    人MTBP重組蛋白
  • 貨號:
    CSB-YP856921HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人MTBP重組蛋白
  • 貨號:
    CSB-EP856921HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人MTBP重組蛋白
  • 貨號:
    CSB-EP856921HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人MTBP重組蛋白
  • 貨號:
    CSB-BP856921HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人MTBP重組蛋白
  • 貨號:
    CSB-MP856921HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    MTBP
  • Uniprot No.:
  • 別名:
    hMTBP; MDM 2 binding protein; MDM 2 BP; MDM2 (mouse double minute 2) binding protein 104kD; MDM2 (mouse double minute 2) binding protein; MDM2 binding protein; MDM2 BP; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein 104kDa; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein binding protein; Mdm2-binding protein; MDM2BP; Mouse double minute 2 homolog binding protein; MTBP; MTBP_HUMAN
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells. May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation.
  • 基因功能參考文獻:
    1. data show that MTBP aggravates the invasion and metastasis of HCC by promoting the MDM2-mediated degradation of E-cadherin. PMID: 26280083
    2. Overexpression of MTBP resulted in the suppression of the migratory and metastatic potential of Hepatocellular carcinoma cells, while its downregulation increased the migration. PMID: 25759210
    3. MTBP significantly contributes to breast cancer survival and is a potential novel therapeutic target in Triple-negative breast cancer . PMID: 24866769
    4. MTBP associated with MYC at promoters and increased MYC-mediated transcription, proliferation, neoplastic transformation, and tumor development. PMID: 24786788
    5. MTBP acts with Treslin/TICRR to integrate signals from cell cycle and DNA damage response pathways to control the initiation of DNA replication in human cells. PMID: 23704573
    6. MTBP also inhibited ACTN4-mediated F-actin bundling. PMID: 22370640
    7. identification and characterization of mouse Mdm2 binding protein PMID: 10906133
    8. MTBP has an important role in recruiting and/or retaining the Mad1/Mad2 complex at the kinetochores during prometaphase, but its degradation is required for silencing the mitotic checkpoint. PMID: 21274008
    9. results represent the first examination of MTBP expression in human tissues and provide evidence for a p53 status-dependent role for MTBP in suppressing disease progression in squamous cell carcinoma of the head and neck patients PMID: 21692053
    10. Data suggest that MTBP differentially regulates the activity of MDM2 towards two of its most critical targets (itself and p53) and in doing so significantly contributes to MDM2-dependent p53 homeostasis in unstressed cells. PMID: 15632057
    11. MTBP contributes to MDM2 activity and through this to negative regulation of p53 PMID: 15632057

    顯示更多

    收起更多

  • 蛋白家族:
    MTBP family
  • 數據庫鏈接:

    HGNC: 7417

    OMIM: 605927

    KEGG: hsa:27085

    STRING: 9606.ENSP00000303398

    UniGene: Hs.657656



主站蜘蛛池模板: 国产精品自在欧美一区| 可以免费观看的av毛片下载| 国产午夜福利视频在线观看| 精品国精品国产自在久国产87| 亚洲理论在线a中文字幕| 无码制服丝袜人妻在线视频精品| 精品人无码一区二区三区| 日韩人妻一区二区三区免费| 无码免费午夜福利看片| 日韩av中文无码影院| 国产精品久久久久久52avav| 国产精品99久久久精品无码| 中文字幕日韩精品亚洲一区| 国产精品嫩草99av在线| 中文字幕av免费专区| 成人午夜视频精品一区| 五月丁香六月激情综合在线视频| 亚洲人成小说网站色在线观看| 久久精品青草社区| 爆爽久久久一区二区又大又黄又嫩| 无码一区二区三区老色鬼| 激情av无码后入| 色噜噜av亚洲色一区二区| 欧美性猛交xxxx黑人| 久久男人av资源网站| 印度女人狂野牲交| 精品亚洲成a人片在线观看少妇| 久久久久欧美国产高潮| 国产美女精品中文网蜜芽宝贝 | 国产精品人成视频免费播放| 国产精品爱久久久久久久| 亚洲狠狠色丁香婷婷综合| 日日日日做夜夜夜夜无码| 18禁裸体动漫美女无遮挡网站 | 久久久橹橹橹久久久久高清| 天堂久久久久va久久久久| 欧美亚洲国产一区二区三区| 毛片tv网站无套内射tv网站| 精品无码一区在线观看| 色欲香天天天综合网站| 天堂在线中文网www|