在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MTBP Antibody

MTBP Antibody

  • 中文名稱：
    MTBP兔多克隆抗體
  • 貨號：
    CSB-PA575736
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA575736(MTBP Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA575736(MTBP Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    MTBP
  • 別名：
    hMTBP antibody; MDM 2 binding protein antibody; MDM 2 BP antibody; MDM2 (mouse double minute 2) binding protein 104kD antibody; MDM2 (mouse double minute 2) binding protein antibody; MDM2 binding protein antibody; MDM2 BP antibody; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein 104kDa antibody; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein antibody; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein binding protein antibody; Mdm2-binding protein antibody; MDM2BP antibody; Mouse double minute 2 homolog binding protein antibody; MTBP antibody; MTBP_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human MTBP
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells. May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation.
  • 基因功能參考文獻：
    1. data show that MTBP aggravates the invasion and metastasis of HCC by promoting the MDM2-mediated degradation of E-cadherin. PMID: 26280083
    2. Overexpression of MTBP resulted in the suppression of the migratory and metastatic potential of Hepatocellular carcinoma cells, while its downregulation increased the migration. PMID: 25759210
    3. MTBP significantly contributes to breast cancer survival and is a potential novel therapeutic target in Triple-negative breast cancer . PMID: 24866769
    4. MTBP associated with MYC at promoters and increased MYC-mediated transcription, proliferation, neoplastic transformation, and tumor development. PMID: 24786788
    5. MTBP acts with Treslin/TICRR to integrate signals from cell cycle and DNA damage response pathways to control the initiation of DNA replication in human cells. PMID: 23704573
    6. MTBP also inhibited ACTN4-mediated F-actin bundling. PMID: 22370640
    7. identification and characterization of mouse Mdm2 binding protein PMID: 10906133
    8. MTBP has an important role in recruiting and/or retaining the Mad1/Mad2 complex at the kinetochores during prometaphase, but its degradation is required for silencing the mitotic checkpoint. PMID: 21274008
    9. results represent the first examination of MTBP expression in human tissues and provide evidence for a p53 status-dependent role for MTBP in suppressing disease progression in squamous cell carcinoma of the head and neck patients PMID: 21692053
    10. Data suggest that MTBP differentially regulates the activity of MDM2 towards two of its most critical targets (itself and p53) and in doing so significantly contributes to MDM2-dependent p53 homeostasis in unstressed cells. PMID: 15632057
    11. MTBP contributes to MDM2 activity and through this to negative regulation of p53 PMID: 15632057

    顯示更多

    收起更多

  • 蛋白家族：
    MTBP family
  • 數據庫鏈接：

    HGNC: 7417

    OMIM: 605927

    KEGG: hsa:27085

    STRING: 9606.ENSP00000303398

    UniGene: Hs.657656



主站蜘蛛池模板： 久久精品中文字幕第一页| 亚洲 另类 日韩 制服 无码| 欧美深性狂猛ⅹxxx深喉| 在线精品动漫一区二区无码| 天堂在线最新版www中文| 麻豆国产精成人品观看免费| 啪啪无码人妻丰满熟妇| 欧美巨大另类极品videosbest| 男人扒开女人内裤强吻桶进去| 日韩乱码在线观看免费视频网站 | 色综合色狠狠天天综合色| 亚洲欧美日韩国产综合在线一区| 亚洲精品乱码久久久久久日本麻豆 | 国产精品区免费视频| 免费看成人欧美片爱潮app| 亚洲国产成人av网站| 国产精品va无码二区| 精品国产乱码一区二区三区| 成人毛片一区二区| 久久久喷潮一区二区三区| 顶级欧美熟妇高潮xxxxx| 狠狠色狠狠色综合| 欧美成人一区二区三区 | 让少妇高潮无乱码高清在线观看| 亚洲熟妇无码av不卡在线播放| 人妻熟女一区| 性色欲情网站iwww| 国产偷窥盗摄一区二区| 精品久久久中文字幕人妻| 99久久久国产精品免费蜜臀| 熟女熟妇伦av网站| 又粗又黄又猛又爽大片免费| 日欧一片内射va在线影院| 老鸭窝视频在线观看| 精品国产丝袜自在线拍国语| 免费观看又色又爽又湿的软件 | 欧洲女人牲交视频免费| 欧美男生射精高潮视频网站| 久久久久77777人人人人人| 女高中生自慰污污网站| 性xxxx18免费观看视频|