在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MTBP Antibody

MTBP Antibody

  • 中文名稱：
    MTBP兔多克隆抗體
  • 貨號：
    CSB-PA575736
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA575736(MTBP Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA575736(MTBP Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    MTBP
  • 別名：
    hMTBP antibody; MDM 2 binding protein antibody; MDM 2 BP antibody; MDM2 (mouse double minute 2) binding protein 104kD antibody; MDM2 (mouse double minute 2) binding protein antibody; MDM2 binding protein antibody; MDM2 BP antibody; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein 104kDa antibody; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein antibody; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein binding protein antibody; Mdm2-binding protein antibody; MDM2BP antibody; Mouse double minute 2 homolog binding protein antibody; MTBP antibody; MTBP_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human MTBP
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells. May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation.
  • 基因功能參考文獻：
    1. data show that MTBP aggravates the invasion and metastasis of HCC by promoting the MDM2-mediated degradation of E-cadherin. PMID: 26280083
    2. Overexpression of MTBP resulted in the suppression of the migratory and metastatic potential of Hepatocellular carcinoma cells, while its downregulation increased the migration. PMID: 25759210
    3. MTBP significantly contributes to breast cancer survival and is a potential novel therapeutic target in Triple-negative breast cancer . PMID: 24866769
    4. MTBP associated with MYC at promoters and increased MYC-mediated transcription, proliferation, neoplastic transformation, and tumor development. PMID: 24786788
    5. MTBP acts with Treslin/TICRR to integrate signals from cell cycle and DNA damage response pathways to control the initiation of DNA replication in human cells. PMID: 23704573
    6. MTBP also inhibited ACTN4-mediated F-actin bundling. PMID: 22370640
    7. identification and characterization of mouse Mdm2 binding protein PMID: 10906133
    8. MTBP has an important role in recruiting and/or retaining the Mad1/Mad2 complex at the kinetochores during prometaphase, but its degradation is required for silencing the mitotic checkpoint. PMID: 21274008
    9. results represent the first examination of MTBP expression in human tissues and provide evidence for a p53 status-dependent role for MTBP in suppressing disease progression in squamous cell carcinoma of the head and neck patients PMID: 21692053
    10. Data suggest that MTBP differentially regulates the activity of MDM2 towards two of its most critical targets (itself and p53) and in doing so significantly contributes to MDM2-dependent p53 homeostasis in unstressed cells. PMID: 15632057
    11. MTBP contributes to MDM2 activity and through this to negative regulation of p53 PMID: 15632057

    顯示更多

    收起更多

  • 蛋白家族：
    MTBP family
  • 數據庫鏈接：

    HGNC: 7417

    OMIM: 605927

    KEGG: hsa:27085

    STRING: 9606.ENSP00000303398

    UniGene: Hs.657656



主站蜘蛛池模板： 亚洲一区二区三区香蕉| 亚洲精品午夜一区人人爽| 国产明星裸体xxxx视频| 亚洲国产婷婷综合在线精品| 99香蕉国产精品偷在线观看| 久久综合亚洲色hezyo国产 | 老熟妇仑乱视频一区二区| 亚洲欧美日韩国产综合v| 欧美特级婬片毛多的少妇| 国产女人喷潮视频在线观看| 99精品久久精品一区二区| 99精品国产一区二区三区| 精品国产一二三产品区别在哪 | 偷妻之寂寞难耐2中文字幕| 蜜桃久久精品成人无码av| 久久久久久人妻一区精品| 久久激情综合狠狠爱五月| 成人午夜亚洲精品无码区| 国产剧情av麻豆香蕉精品| 免费视频爱爱太爽了| 久久国产精品人妻丝袜| 亚洲精品国偷拍自产在线观看蜜桃| 92国产精品午夜福利| 野花社区在线www日本| 亚洲精品午夜无码电影网| 亚洲精品一区久久久久久 | 98久9在线 | 免费| 国产激情精品一区二区三区| 欧美成 人版中文字幕| 图片区小说区亚洲欧美自拍| 少妇粉嫩小泬喷水视频www| 妺妺窝人体色www在线小说| 亚洲另类欧美小说图片区 | 婷婷无套内射影院| 无码精品国产一区二区免费| 成人伊人青草久久综合网| 欧美黑人疯狂性受xxxxx喷水| 国产麻豆 9l 精品三级站| 国产98在线 | 免费| 国产又大又黑又粗免费视频| 久久99精品久久久久久齐齐|