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  4. MGME1 Antibody, HRP conjugated

MGME1 Antibody, HRP conjugated

  • 中文名稱：
    MGME1兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA880084LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) MGME1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MGME1
  • 別名：
    MGME1 antibody; C20orf72 antibody; DDK1Mitochondrial genome maintenance exonuclease 1 antibody; EC 3.1.-.- antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Mitochondrial genome maintenance exonuclease 1 protein (81-260AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair. Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells.
  • 基因功能參考文獻：
    1. MGME1 is part of a termination complex acting at the end of the D-loop region where it modulates mtDNA replication and H-strand transcription termination PMID: 29572490
    2. A novel frameshift deletion in MGME1 causes early onset cerebellar ataxia. PMID: 28711739
    3. MGME1 processes flaps into ligatable nicks in concert with DNA polymerase gamma during mtDNA replication. PMID: 27220468
    4. MGME1-mediated mtDNA processing is essential for faithful mitochondrial genome replication and might be required for intramolecular recombination of mtDNA. PMID: 24986917
    5. Overexperssion of Ddk1 decreases the levels of 7S DNA, suggesting an important role of the protein in 7S DNA regulation. PMID: 23358826
    6. Loss-of-function mutations in MGME1 impair mtDNA replication and cause multisystemic mitochondrial disease. PMID: 23313956

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  • 相關疾病：
    Mitochondrial DNA depletion syndrome 11 (MTDPS11)
  • 亞細胞定位：
    Mitochondrion.
  • 蛋白家族：
    MGME1 family
  • 數據庫鏈接：

    HGNC: 16205

    OMIM: 615076

    KEGG: hsa:92667

    STRING: 9606.ENSP00000366939

    UniGene: Hs.320823



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