在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MAPK6 Antibody

MAPK6 Antibody

  • 中文名稱：
    MAPK6兔多克隆抗體
  • 貨號：
    CSB-PA030293
  • 規格：
    ￥1090
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    ERK-3 antibody; ERK3 antibody; Extracellular signal regulated kinase 3 antibody; Extracellular signal regulated kinase p97 antibody; Extracellular signal-regulated kinase 3 antibody; HsT17250 antibody; MAP kinase 6 antibody; MAP kinase isoform p97 antibody; MAPK 6 antibody; MAPK6 antibody; Mitogen activated protein kinase 6 antibody; Mitogen-activated protein kinase 6 antibody; MK06_HUMAN antibody; p97 MAPK antibody; p97-MAPK antibody; PRKM6 antibody; Protein kinase mitogen activated 5 antibody; Protein kinase mitogen activated 6 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human ERK 3.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, IF, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:10000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle.
  • 基因功能參考文獻：
    1. Metformin sensitizes arsenic trioxide to suppress intrahepatic cholangiocarcinoma via the regulation of AMPK/p38 MAPK-ERK3/mTORC1 pathways. ERK3 is a newfound potential prognostic predictor and a tumor suppressor in ICC. PMID: 28241849
    2. Study revealed a post-translational regulation of TDP2 activity and discovered a new role of ERK3 in increasing cancer cells' DNA damage response and chemoresistance to Top2 inhibitors. PMID: 26701725
    3. MAPK6 could rescue the cell growth induced by miR499a and HBV PMID: 25340781
    4. ERK3 regulates endothelial cell migration, proliferation and tube formation by upregulating SRC-3/SP-1-mediated VEGFR2 expression. PMID: 24585635
    5. These findings further expand distinct roles of cyclin D3 and suggest the potential activity of ERK3 in cell proliferation. PMID: 16360641
    6. Cdc14A forms a stable complex with atypical mitogen-activated protein kinase Erk3 in human cells independent of its intrinsic phosphatase activity but mediated by its regulatory C-terminal domain. PMID: 18235225
    7. identify the Erk3 protein as a novel class I Pak substrate and further suggest a role for Pak kinase activity in atypical MAPK signaling. PMID: 21317288
    8. A previously unknown role for ERK3 in promoting lung cancer cell invasiveness by phosphorylating SRC-3 and regulating SRC-3 proinvasive activity by site-specific phosphorylation. PMID: 22505454
    9. ERK3 biological activity is regulated by its cellular abundance through the control of protein stability PMID: 12808096
    10. Data show that extracellular signal-regulated kinase 3 (ERK3) is conjugated to ubiquitin via its free NH(2) terminus, and that N-terminal tags stabilize expression of p21 but not that of substrates ubiquitinated on internal lysine residues. PMID: 15226418
    11. Extracellular signal-regulated kinase-3 (ERK3/MAPK6) is highly expressed in response to BRAF signaling. PMID: 16964379

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily
  • 組織特異性：
    Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts.
  • 數據庫鏈接：

    HGNC: 6879

    OMIM: 602904

    KEGG: hsa:5597

    STRING: 9606.ENSP00000261845

    UniGene: Hs.411847



主站蜘蛛池模板： 久久人人妻人人爽人人爽| 久青草国产97香蕉在线视频| 免费va人成视频网站全| 国产sp调教打屁股视频网站| 欧美在线观看免费专区| 日韩aⅴ人妻无码一区二区| 国产欧美精品一区二区三区| 国产精品久久久久久爽爽爽| 欧美一区二区三区视频在线观看| 好了av在线第四综合网站| 欧洲丰满少妇a毛片| 精品日产高清卡4卡5区别| 久久精品99国产精品日本| 国产jk精品白丝av在线观看| 麻豆精品国产精华精华液好用吗 | 国产片av片永久免费观看| 久久人妻夜夜做天天爽| 丰满人妻一区二区三区免费视频| 亚洲日本一区二区一本一道| 一本久道久久综合狠狠爱 | 疯狂迎合进入强壮公的视频| 久久综合伊人中文字幕| 丰满人妻翻云覆雨呻吟视频| 久久婷婷五月综合色一区二区 | 欧洲日韩亚洲无线在码| 一区二区视频日韩免费| 欧美3p两根一起进高清视频| 高潮毛片无遮挡高清免费| 欧美野外疯狂做受xxxx高潮| 国产精品亚洲а∨天堂网| 韩国国内大量揄拍精品视频| 中国女人内谢69xxxx免费视频| 情人伊人久久综合亚洲| 色狠狠av一区二区三区| 强伦姧人妻免费无码电影| 亚洲综合另类小说专区| 国产精品久久午夜夜伦鲁鲁| 国产成人综合欧美精品久久| 亚拍精品一区二区三区探花 | 国产亚洲香蕉线播放αv38| 综合色就爱涩涩涩综合婷婷|