在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. HECW1 Antibody, HRP conjugated

HECW1 Antibody, HRP conjugated

  • 中文名稱：
    HECW1兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA748484HB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) HECW1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    HECW1
  • 別名：
    C2 and WW domain-containing protein 1 antibody; E3 ubiquitin-protein ligase HECW1 antibody; HECT antibody; HECT type E3 ubiquitin ligase antibody; HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 antibody; HECT, C2 and WW domain-containing protein 1 antibody; HECW 1 antibody; Hecw1 antibody; HECW1_HUMAN antibody; hNEDL1 antibody; NEDD4 like ubiquitin protein ligase 1 antibody; NEDD4-like E3 ubiquitin-protein ligase 1 antibody; NEDL1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human E3 ubiquitin-protein ligase HECW1 protein (751-900AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Antigen Affinity purified & Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.
  • 基因功能參考文獻：
    1. Ndel1 acts as a novel upstream regulator of the trichoplein-Aurora A pathway to inhibit primary cilia assembly. PMID: 26880200
    2. Ndel1 regulates Dyn2 GTPase activity and impacts GluR1-containing membranes distribution in a manner reminiscent of Dyn2. PMID: 21283621
    3. These findings suggest that the human NEDL1 transgenic mice might develop Amyotrophic lateral sclerosis-like symptoms, showing signs of motor abnormalities, accompanied with significant reduction in muscle strength. PMID: 20976258
    4. These findings suggest that RNF43 is associated with p53-mediated apoptosis in collaboration with NEDL1 in colorectal carcinogenesis. PMID: 21108931
    5. interaction among misfolded SOD1, NEDL1, translocon-associated protein-delta, and Dishevelled-1 forms a ubiquitinated protein complex that is included in potentially cytotoxic protein aggregates PMID: 14684739
    6. functional interaction of NEDL1 with p53 might contribute to the induction of apoptosis in cancerous cells bearing wild-type p53. PMID: 18223681

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm.
  • 組織特異性：
    Predominantly expressed in neurons of adult and fetal brain. Weakly expressed in the kidney.
  • 數據庫鏈接：

    HGNC: 22195

    OMIM: 610384

    KEGG: hsa:23072

    STRING: 9606.ENSP00000379228

    UniGene: Hs.164453



主站蜘蛛池模板： 久久人人爽人人爽人人av东京热| 狼友网精品视频在线观看| 欧洲国产精品无码专区影院| 麻豆国产一区二区三区四区| 色婷婷久久综合中文久久蜜桃av| 又色又爽又高潮免费视频观看 | 亚洲精品人成网线在播放va| 午夜男女xx00视频福利| 波多野结衣av手机在线观看| 女女同性av片在线观看免费 | 欧美变态另类牲交| 亚洲愉拍二区一区三区| 亚洲成a人片在线观看www| 亚洲男人的天堂网站| 日本视频免费高清一本18| 男人边吃奶边揉好爽免费视频| 久久久久久a亚洲欧洲av冫| 小嫩妇好紧好爽再快视频| 奇米777国产在线视频| 国产亚洲日韩在线a不卡| 久久综合九色综合网站| 国产人妻aⅴ色偷| 色欲天天天综合网| 亚洲美女被黑人巨大在线播放 | 2020精品国产自在现线看| 欧美成人精精品一区二区| 高中生粉嫩无套第一次| 国产卡一卡二卡三| 肉大榛一进一出免费视频| 久久国产精品国产四虎90后| 波多野结衣av在线观看| 精品少妇人妻av一区二区三区| 国产亚洲精品a在线| 亚洲国产精品成人影片久久| 国产精品亚洲色婷婷99久久精品 | 成人影院yy111111| 播放男人添女人下边视频| 久久人人97超碰爱香蕉| 久久精品国产2020| 中国女人内谢69xxxx视频| 久久www免费人成_看片|