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  4. HECW1 Antibody, Biotin conjugated

HECW1 Antibody, Biotin conjugated

  • 中文名稱：
    HECW1兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA748484HD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) HECW1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    HECW1
  • 別名：
    C2 and WW domain-containing protein 1 antibody; E3 ubiquitin-protein ligase HECW1 antibody; HECT antibody; HECT type E3 ubiquitin ligase antibody; HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 antibody; HECT, C2 and WW domain-containing protein 1 antibody; HECW 1 antibody; Hecw1 antibody; HECW1_HUMAN antibody; hNEDL1 antibody; NEDD4 like ubiquitin protein ligase 1 antibody; NEDD4-like E3 ubiquitin-protein ligase 1 antibody; NEDL1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human E3 ubiquitin-protein ligase HECW1 protein (751-900AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Antigen Affinity purified & Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.
  • 基因功能參考文獻：
    1. Ndel1 acts as a novel upstream regulator of the trichoplein-Aurora A pathway to inhibit primary cilia assembly. PMID: 26880200
    2. Ndel1 regulates Dyn2 GTPase activity and impacts GluR1-containing membranes distribution in a manner reminiscent of Dyn2. PMID: 21283621
    3. These findings suggest that the human NEDL1 transgenic mice might develop Amyotrophic lateral sclerosis-like symptoms, showing signs of motor abnormalities, accompanied with significant reduction in muscle strength. PMID: 20976258
    4. These findings suggest that RNF43 is associated with p53-mediated apoptosis in collaboration with NEDL1 in colorectal carcinogenesis. PMID: 21108931
    5. interaction among misfolded SOD1, NEDL1, translocon-associated protein-delta, and Dishevelled-1 forms a ubiquitinated protein complex that is included in potentially cytotoxic protein aggregates PMID: 14684739
    6. functional interaction of NEDL1 with p53 might contribute to the induction of apoptosis in cancerous cells bearing wild-type p53. PMID: 18223681

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  • 亞細胞定位：
    Cytoplasm.
  • 組織特異性：
    Predominantly expressed in neurons of adult and fetal brain. Weakly expressed in the kidney.
  • 數據庫鏈接：

    HGNC: 22195

    OMIM: 610384

    KEGG: hsa:23072

    STRING: 9606.ENSP00000379228

    UniGene: Hs.164453



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