在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. GM2A Antibody

GM2A Antibody

  • 中文名稱：
    GM2A兔多克隆抗體
  • 貨號：
    CSB-PA02379A0Rb
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: GM2A antibody at 10µg/ml
      Lane 1: Rat liver tissue
      Lane 2: Mouse stomach tissue
      Lane 3: Mouse small intestine tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 21 kDa
      Observed band size: 21 kDa
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA02379A0Rb at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA02379A0Rb at dilution of 1:100
    • Immunoprecipitating GM2A in HEK293 whole cell lysate
      Lane 1: Rabbit control IgG instead of CSB-PA02379A0Rb in HEK293 whole cell lysate. For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
      Lane 2: CSB-PA02379A0Rb (8µg) + HEK293 whole cell lysate (500µg)
      Lane 3: HEK293 whole cell lysate (10µg)
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) GM2A Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    GM2A
  • 別名：
    Cerebroside sulfate activator protein antibody; ganglioside GM2 activator antibody; Ganglioside GM2 activator isoform short antibody; Ganglioside GM2 activator precursor antibody; GM2 activator antibody; GM2 AP antibody; GM2 ganglioside activator antibody; GM2 ganglioside activator protein antibody; GM2-AP antibody; GM2A antibody; GM2AP antibody; OTTHUMP00000160619 antibody; SAP 3 antibody; SAP-3 antibody; SAP3 antibody; SAP3_HUMAN antibody; Shingolipid activator protein 3 antibody; Sphingolipid activator protein 3 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human Ganglioside GM2 activator protein (32-193AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，GM2A Antibody (CSB-PA02379A0Rb)，的標(biāo)記方式是Non-conjugated。對于GM2A Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA02379B0Rb GM2A Antibody, HRP conjugated ELISA
    FITC CSB-PA02379C0Rb GM2A Antibody, FITC conjugated
    Biotin CSB-PA02379D0Rb GM2A Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC, IP
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-5000
    IHC 1:20-1:200
    IP 1:200-1:2000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity. Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3. Has cholesterol transfer activity.
  • 基因功能參考文獻(xiàn)：
    1. Review of GM2A mutations causing GM2 activator protein deficiency and GM2 gangliosidosis-AB variant. PMID: 27402091
    2. Studies indicate that sphingolipid activator proteins (SAPs) and anionic lipids are essential stimulators to reach physiological rates of lysosomal sphingolipid degradation. PMID: 27157270
    3. this study has established the potential role of GM2A in breast cancer progression PMID: 27002480
    4. Mobilization of membrane lipids by GM2AP was also inhibited in the presence of cholesterol or SM, as revealed by surface plasmon resonance studies PMID: 26175473
    5. Gene polymorphisms of MD2 and GM2A were associated with the occurrence or severity of neonatal necrotizing enterocolitis. PMID: 25816011
    6. In vitro assays with the isolated H1 or H2 homodimers (beta-alpha hybrid construct of beta-hexosaminidase A subunits) confirmed that neither was capable of human GM2AP-dependent hydrolysis of GM2 ganglioside. PMID: 23483939
    7. impact of GM2AP on glucose metabolism PMID: 21784073
    8. Treatment of meniscal explants with IL-1RA inhibited the expression of many catabolic genes following a single bout of high dynamic strain. PMID: 21331553
    9. these results provide novel insights into the physiological functions of GM2AP in obesity. PMID: 21036149
    10. GM2 activator protein exerts strong and broad inhibitory effects on the hydrolysis of phospholipids carried out by plant and microbial phospholipases D PMID: 12576516
    11. Two new structures of GM2-AP with bound lipids, showing two different lipid-binding modes within the apolar pocket PMID: 12909021
    12. elucidation of mode of action on gangioside GM2 PMID: 14728689
    13. alpha-subunit loop structure is required for GM2 activator protein binding by beta-hexosaminidase A PMID: 15485660
    14. glycosphingolipids, particularly GM2, form a complex with CD82, and this complex interacts with Met and thereby inhibits HGF-induced Met tyrosine kinase activity, as well as integrin to Met cross-talk PMID: 17215249

    顯示更多

    收起更多

  • 相關(guān)疾病：
    GM2-gangliosidosis AB (GM2GAB)
  • 亞細(xì)胞定位：
    Lysosome.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 4367

    OMIM: 272750

    KEGG: hsa:2760

    STRING: 9606.ENSP00000349687

    UniGene: Hs.483873



主站蜘蛛池模板： 国产精品进线69影院| 欧美综合精品久久久久成人影院 | 国产啪精品视频网站| 日本高清色倩视频在线观看| 精品午夜福利无人区乱码一区| 亚洲熟女乱色综合亚洲图片| 欧美亚洲精品中文字幕乱码| 日韩精品一区二区三区影院| 久久综合色_综合色88| 久久久婷婷五月亚洲97色| 亚洲人成图片小说网站| 精品无人区无码乱码毛片国产 | 插我一区二区在线观看| 动漫精品啪啪一区二区三区| 国产伦精品一区二区三区妓女下载| 爱色精品视频一区二区| 人人玩人人添人人澡欧美| 嫩草研究院久久久精品| 人妻体内射精一区二区三四| 人妻少妇精品中文字幕av| 日日噜噜夜夜狠狠久久丁香五月| 好日子在线观看视频大全免费动漫| 国产午夜福利小视频合集| 超碰97久久国产精品牛牛| 97久久超碰亚洲视觉盛宴| 国产亚洲精品久久久久秋霞| 亚洲成av人片不卡无码久久| 亚洲精品中文字幕乱码4区| 国产丝袜视频一区二区三区| 欧美午夜精品久久久久久浪潮| 久久99亚洲含羞草影院| 国产成人精品日本亚洲成熟| 粉嫩小泬无遮挡久久久久久| 国产高潮国产高潮久久久| 国产喷水1区2区3区咪咪爱av| 又大又粗又爽又黄的少妇毛片| 日产精品一二三区| 97久久精品亚洲中文字幕无码| 精品久久久久久无码不卡| 亚洲最大成人网 色香蕉| 国产无遮挡又黄又爽在线观看|