在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. GM2A Antibody, FITC conjugated

GM2A Antibody, FITC conjugated

  • 中文名稱：
    GM2A兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA02379C0Rb
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) GM2A Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    GM2A
  • 別名：
    Cerebroside sulfate activator protein antibody; ganglioside GM2 activator antibody; Ganglioside GM2 activator isoform short antibody; Ganglioside GM2 activator precursor antibody; GM2 activator antibody; GM2 AP antibody; GM2 ganglioside activator antibody; GM2 ganglioside activator protein antibody; GM2-AP antibody; GM2A antibody; GM2AP antibody; OTTHUMP00000160619 antibody; SAP 3 antibody; SAP-3 antibody; SAP3 antibody; SAP3_HUMAN antibody; Shingolipid activator protein 3 antibody; Sphingolipid activator protein 3 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Ganglioside GM2 activator protein (32-193AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity. Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3. Has cholesterol transfer activity.
  • 基因功能參考文獻：
    1. Review of GM2A mutations causing GM2 activator protein deficiency and GM2 gangliosidosis-AB variant. PMID: 27402091
    2. Studies indicate that sphingolipid activator proteins (SAPs) and anionic lipids are essential stimulators to reach physiological rates of lysosomal sphingolipid degradation. PMID: 27157270
    3. this study has established the potential role of GM2A in breast cancer progression PMID: 27002480
    4. Mobilization of membrane lipids by GM2AP was also inhibited in the presence of cholesterol or SM, as revealed by surface plasmon resonance studies PMID: 26175473
    5. Gene polymorphisms of MD2 and GM2A were associated with the occurrence or severity of neonatal necrotizing enterocolitis. PMID: 25816011
    6. In vitro assays with the isolated H1 or H2 homodimers (beta-alpha hybrid construct of beta-hexosaminidase A subunits) confirmed that neither was capable of human GM2AP-dependent hydrolysis of GM2 ganglioside. PMID: 23483939
    7. impact of GM2AP on glucose metabolism PMID: 21784073
    8. Treatment of meniscal explants with IL-1RA inhibited the expression of many catabolic genes following a single bout of high dynamic strain. PMID: 21331553
    9. these results provide novel insights into the physiological functions of GM2AP in obesity. PMID: 21036149
    10. GM2 activator protein exerts strong and broad inhibitory effects on the hydrolysis of phospholipids carried out by plant and microbial phospholipases D PMID: 12576516
    11. Two new structures of GM2-AP with bound lipids, showing two different lipid-binding modes within the apolar pocket PMID: 12909021
    12. elucidation of mode of action on gangioside GM2 PMID: 14728689
    13. alpha-subunit loop structure is required for GM2 activator protein binding by beta-hexosaminidase A PMID: 15485660
    14. glycosphingolipids, particularly GM2, form a complex with CD82, and this complex interacts with Met and thereby inhibits HGF-induced Met tyrosine kinase activity, as well as integrin to Met cross-talk PMID: 17215249

    顯示更多

    收起更多

  • 相關(guān)疾?。?/div>
    GM2-gangliosidosis AB (GM2GAB)
  • 亞細胞定位：
    Lysosome.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 4367

    OMIM: 272750

    KEGG: hsa:2760

    STRING: 9606.ENSP00000349687

    UniGene: Hs.483873



主站蜘蛛池模板： 黑人猛挺进小莹的体内视频| 欧美人与禽zozzo性伦交| 亚洲精品卡一卡三卡四卡乱码| 亚洲伊人色欲综合网无码中文 | 国产狂喷潮在线观看中文| 免费人成视频在线观看网站| 久久国产成人午夜av影院| 国产动作大片中文字幕| 国产精品人成视频国模| 亚洲欧美人高清精品a∨| 国产综合一区二区三区黄页秋霞| 亚洲愉拍99热成人精品热久久| 熟女少妇人妻中文字幕| 成年无码av片在线| 高清国产一区二区三区在线| 丁香狠狠色婷婷久久综合| 日本无码人妻一区二区色欲 | a毛看片免费观看视频| 亚洲手机在线人成网站| 国产av天堂亚洲国产av天堂| 亚洲人成在线影院| 久久综合色鬼综合色| 亚洲香蕉网久久综合影视| 少妇大胆瓣开下部自慰| 少妇精品无码一区二区免费视频| 男女做爰真人视频直播| 亚洲中文字幕久在线| 亚洲精品国产自在久久| 久久狠狠色噜噜狠狠狠狠97| 日日澡夜夜澡人人高潮| 久久久综合九色合综国产精品| 久久免费精品国产72精品九九 | 久久视频这里只有精品在线观看| 中文无码日韩欧av影视| 午夜精品久久久久久久| 亚洲久久中文字幕www网站| 国产在线午夜不卡精品影院| 亚洲精品在看在线观看高清| 亚洲精品亚洲人成人网| 欧洲日韩亚洲无线在码| 无码人妻天天拍夜夜爽|