在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. GM2A Antibody, HRP conjugated

GM2A Antibody, HRP conjugated

  • 中文名稱：
    GM2A兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA02379B0Rb
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) GM2A Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    GM2A
  • 別名：
    Cerebroside sulfate activator protein antibody; ganglioside GM2 activator antibody; Ganglioside GM2 activator isoform short antibody; Ganglioside GM2 activator precursor antibody; GM2 activator antibody; GM2 AP antibody; GM2 ganglioside activator antibody; GM2 ganglioside activator protein antibody; GM2-AP antibody; GM2A antibody; GM2AP antibody; OTTHUMP00000160619 antibody; SAP 3 antibody; SAP-3 antibody; SAP3 antibody; SAP3_HUMAN antibody; Shingolipid activator protein 3 antibody; Sphingolipid activator protein 3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Ganglioside GM2 activator protein (32-193AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity. Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3. Has cholesterol transfer activity.
  • 基因功能參考文獻：
    1. Review of GM2A mutations causing GM2 activator protein deficiency and GM2 gangliosidosis-AB variant. PMID: 27402091
    2. Studies indicate that sphingolipid activator proteins (SAPs) and anionic lipids are essential stimulators to reach physiological rates of lysosomal sphingolipid degradation. PMID: 27157270
    3. this study has established the potential role of GM2A in breast cancer progression PMID: 27002480
    4. Mobilization of membrane lipids by GM2AP was also inhibited in the presence of cholesterol or SM, as revealed by surface plasmon resonance studies PMID: 26175473
    5. Gene polymorphisms of MD2 and GM2A were associated with the occurrence or severity of neonatal necrotizing enterocolitis. PMID: 25816011
    6. In vitro assays with the isolated H1 or H2 homodimers (beta-alpha hybrid construct of beta-hexosaminidase A subunits) confirmed that neither was capable of human GM2AP-dependent hydrolysis of GM2 ganglioside. PMID: 23483939
    7. impact of GM2AP on glucose metabolism PMID: 21784073
    8. Treatment of meniscal explants with IL-1RA inhibited the expression of many catabolic genes following a single bout of high dynamic strain. PMID: 21331553
    9. these results provide novel insights into the physiological functions of GM2AP in obesity. PMID: 21036149
    10. GM2 activator protein exerts strong and broad inhibitory effects on the hydrolysis of phospholipids carried out by plant and microbial phospholipases D PMID: 12576516
    11. Two new structures of GM2-AP with bound lipids, showing two different lipid-binding modes within the apolar pocket PMID: 12909021
    12. elucidation of mode of action on gangioside GM2 PMID: 14728689
    13. alpha-subunit loop structure is required for GM2 activator protein binding by beta-hexosaminidase A PMID: 15485660
    14. glycosphingolipids, particularly GM2, form a complex with CD82, and this complex interacts with Met and thereby inhibits HGF-induced Met tyrosine kinase activity, as well as integrin to Met cross-talk PMID: 17215249

    顯示更多

    收起更多

  • 相關疾病：
    GM2-gangliosidosis AB (GM2GAB)
  • 亞細胞定位：
    Lysosome.
  • 數據庫鏈接：

    HGNC: 4367

    OMIM: 272750

    KEGG: hsa:2760

    STRING: 9606.ENSP00000349687

    UniGene: Hs.483873



主站蜘蛛池模板： 欧美成人精品一区二区三区色欲| 亚洲美女精品免费视频| 又黄又爽又色的视频| 蜜臀av国产一区二区三区| 久久国产欧美成人av| 久久精品国自产拍| 色婷婷综合久久久久中文| 999久久久国产精品消防器材| 伊人久久大香线蕉亚洲| 久久久久亚洲精品天堂| 欧美成人无码a区视频在线观看| 无码国产69精品久久久孕妇| 99精品国产在热久久| 樱花草在线社区www中国中文 | 欧洲亚洲1卡二卡三卡2021| 免费无码午夜福利片69| 人妻被按摩到潮喷中文不卡| 久久精品国产99精品国产2021| 新婚少妇无套内谢国语播放| 黄页网站在线观看免费视频| 亚洲国产成人精品无码区四虎| 欧美老妇人与禽交| 人妻丝袜中文无码av影音先锋专区 | 天天躁日日躁狠狠躁视频2021| 中国精品少妇hd| 亚洲 欧美 成人 自拍 高清| 国产一区二区亚洲精品| 国产精品白丝av网站在线观看| 在线观看国产一区二区三区| 久久无码专区国产精品s| 国产精品无码电影在线观看| 国产一区二区三区四区精华| 日韩人妻ol丝袜av一二区| 亚洲欧美中文日韩v在线观看| 中国xxxx做受视频| 少妇人妻中文字幕污| 人妻熟女一区二区aⅴ千叶宁真 | 欧美激情一区二区三区高清视频| 无码中文字幕av免费放| 丰满少妇在线观看网站| 少妇三级全黄|