在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. FUNDC1 Antibody

FUNDC1 Antibody

  • 中文名稱：
    FUNDC1兔多克隆抗體
  • 貨號：
    CSB-PA816886LA01HU
  • 規格：
    ￥3900
  • 圖片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate(20μg), MCF-7 whole cell lysate(20μg), A549 whole cell lysate(20μg), PC-3 whole cell lysate(20μg), U-251 whole cell lysate(20μg), K562 whole cell lysate(20μg),Mouse Brain tissue lysate(20μg)
      All lanes: FUNDC1 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/20000 dilution
      Predicted band size: 17-19 kDa
      Observed band size: 25 kDa
      Exposure time: 300s
    • IHC image of CSB-PA816886LA01HU diluted at 1:60 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody
    • Immunofluorescence staining of MCF7 cell with CSB-PA816886LA01HU at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and and permeated by 0.2% TritonX-100 for 15 min. Then 10% normal goat serum to block non-specific protein-protein interactions . The cells were then incubated with the antibody overnight at 4℃. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) FUNDC1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    FUNDC1; FUN14 domain-containing protein 1
  • 宿主：
    Rabbit
  • 反應種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human FUN14 domain-containing protein 1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Constituents: 50% Glycerol, PBS, pH 7.3
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
    IF 1:10-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control.
  • 基因功能參考文獻：
    1. Our data suggested that FUNDC1 can be used as a prognostic biomarker in patients with cervical cancer, and may be a new therapeutic target to improve the antitumor effects of chemoradiotherapy. PMID: 28719148
    2. phosphorylation of Tyr18 of FUNDC1 serves as a molecular switch for mitophagy. PMID: 27653272
    3. FUNDC1 integrates mitochondrial fission and mitophagy at the interface of the endoplasmic reticulum-mitochondrial contact site by working in concert with DRP1 and calnexin under hypoxic conditions in mammalian cells. PMID: 27145933
    4. FUNDC1 regulates both mitochondrial fission or fusion and mitophagy. PMID: 27050458
    5. The BCL2L1-PGAM5-FUNDC1 axis is critical for receptor-mediated mitophagy. PMID: 25126723
    6. FUNDC1 regulates ULK1 recruitment to damaged mitochondria, where FUNDC1 phosphorylation by ULK1 is crucial for mitophagy. PMID: 24671035
    7. Data show that Knockdown of endogenous FUNDC1 significantly prevented hypoxia-induced mitophagy, which could be reversed by the expression of wild-type FUNDC1. PMID: 22267086

    顯示更多

    收起更多

  • 亞細胞定位：
    Mitochondrion outer membrane; Multi-pass membrane protein.
  • 蛋白家族：
    FUN14 family
  • 組織特異性：
    Widely expressed.
  • 數據庫鏈接：

    HGNC: 28746

    OMIM: 300871

    KEGG: hsa:139341

    STRING: 9606.ENSP00000367284

    UniGene: Hs.7549



主站蜘蛛池模板： 日韩人妻无码精品专区906188| 韩国精品一区二区无码视频| 婷婷四房综合激情五月| 97se亚洲国产综合自在线尤物| 伊人伊成久久人综合网996| 无码专区—va亚洲v专区| 小说区 图片区色 综合区| 在线观看国产精品电影| 亚洲日韩小电影在线观看| 亚洲国产欧美日韩在线人成| 各种少妇正面bbw撒尿| 国产精品亚洲专区无码web| 专干熟肥老妇人视频在线看| 2021自拍偷在线精品自拍偷| 国产精品毛片无遮挡高清| 色综合av综合无码综合网站| 亚洲高请码在线精品av| 中文无码日韩欧免费视频 | 丰满五十六十老熟女hd| 伊人情人色综合网站| 亚洲一卡一卡二新区迎热烈讨论| 久久精品国产99久久久| 国产成人无码18禁午夜福利p| 无码国产午夜福利片在线观看 | 国产精品99久久免费| 久久人人97超碰a片精品| 欧美精品在线观看| 一二三四在线观看免费视频| 精品aⅴ一区二区三区| 一边吃奶一边添p好爽高清视频 | 欧美性videos高清精品| 少妇饥渴偷公乱av在线观看涩爱| 日本乱妇乱子视频| 国产精品自产拍高潮在线观看| 亚洲www啪成人一区二区| 成 人影片 免费观看在线| 亚洲 日本 欧美 中文幕 | 香港三级韩国三级日本三级 | 欧洲多毛裸体xxxxx| av激情亚洲男人的天堂| 午夜男女xx00视频福利|