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  4. FUNDC1 Antibody

FUNDC1 Antibody

  • 中文名稱：
    FUNDC1兔多克隆抗體
  • 貨號：
    CSB-PA816886LA01HU
  • 規格：
    ￥3900
  • 圖片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate(20μg), MCF-7 whole cell lysate(20μg), A549 whole cell lysate(20μg), PC-3 whole cell lysate(20μg), U-251 whole cell lysate(20μg), K562 whole cell lysate(20μg),Mouse Brain tissue lysate(20μg)
      All lanes: FUNDC1 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/20000 dilution
      Predicted band size: 17-19 kDa
      Observed band size: 25 kDa
      Exposure time: 300s
    • IHC image of CSB-PA816886LA01HU diluted at 1:60 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody
    • Immunofluorescence staining of MCF7 cell with CSB-PA816886LA01HU at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and and permeated by 0.2% TritonX-100 for 15 min. Then 10% normal goat serum to block non-specific protein-protein interactions . The cells were then incubated with the antibody overnight at 4℃. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) FUNDC1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    FUNDC1; FUN14 domain-containing protein 1
  • 宿主：
    Rabbit
  • 反應種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human FUN14 domain-containing protein 1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Constituents: 50% Glycerol, PBS, pH 7.3
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
    IF 1:10-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control.
  • 基因功能參考文獻：
    1. Our data suggested that FUNDC1 can be used as a prognostic biomarker in patients with cervical cancer, and may be a new therapeutic target to improve the antitumor effects of chemoradiotherapy. PMID: 28719148
    2. phosphorylation of Tyr18 of FUNDC1 serves as a molecular switch for mitophagy. PMID: 27653272
    3. FUNDC1 integrates mitochondrial fission and mitophagy at the interface of the endoplasmic reticulum-mitochondrial contact site by working in concert with DRP1 and calnexin under hypoxic conditions in mammalian cells. PMID: 27145933
    4. FUNDC1 regulates both mitochondrial fission or fusion and mitophagy. PMID: 27050458
    5. The BCL2L1-PGAM5-FUNDC1 axis is critical for receptor-mediated mitophagy. PMID: 25126723
    6. FUNDC1 regulates ULK1 recruitment to damaged mitochondria, where FUNDC1 phosphorylation by ULK1 is crucial for mitophagy. PMID: 24671035
    7. Data show that Knockdown of endogenous FUNDC1 significantly prevented hypoxia-induced mitophagy, which could be reversed by the expression of wild-type FUNDC1. PMID: 22267086

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  • 亞細胞定位：
    Mitochondrion outer membrane; Multi-pass membrane protein.
  • 蛋白家族：
    FUN14 family
  • 組織特異性：
    Widely expressed.
  • 數據庫鏈接：

    HGNC: 28746

    OMIM: 300871

    KEGG: hsa:139341

    STRING: 9606.ENSP00000367284

    UniGene: Hs.7549



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