在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. AK2 Antibody

AK2 Antibody

  • 中文名稱：
    AK2兔多克隆抗體
  • 貨號：
    CSB-PA141591
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA141591(AK2 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA141591(AK2 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-7: Human placenta tissue, A549 cells, mouse brain tissue, hepG2 cells, Raji cells, human fetal liver tissue, hela cells, Primary antibody: CSB-PA141591(AK2 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    AK2
  • 別名：
    Adenylate kinase 2 antibody; adenylate kinase 2, mitochondrial antibody; Adenylate kinase isoenzyme 2 antibody; ADK2 antibody; AK 2 antibody; ak2 antibody; ATP AMP transphosphorylase antibody; ATP-AMP transphosphorylase 2 antibody; EC 2.7.4.3 antibody; KAD2_HUMAN antibody; mitochondrial antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human AK2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
  • 基因功能參考文獻：
    1. Genetic variants of AK2 activates tenofovir for HIV therapy. PMID: 29641561
    2. Reticular dysgenesis -patient derived induced pluripotent stem cells can recapitulate disease phenotype which can be rescued by AK2 overexpression. PMID: 29462620
    3. In conclusion, our data suggest that SIRPalpha signaling through SHP-2-PI3K-Akt2 strongly influences osteoblast differentiation from bone marrow stromal cells. PMID: 27422603
    4. AK2 deficiency compromises the mitochondrial energy metabolism required for differentiation of human neutrophil and lymphoid lineages. PMID: 26270350
    5. results suggest that AK2 is an associated activator of DUSP26 and suppresses cell proliferation by FADD dephosphorylation, postulating AK2 as a negative regulator of tumour growth. PMID: 24548998
    6. AK2 is indispensable for neutrophil differentiation, indicating a possible causative link between AK2 deficiency and neutropenia in reticular dysgenesis. PMID: 24587121
    7. These results suggest that, acting in concert with FADD and caspase-10, AK2 mediates a novel intrinsic apoptotic pathway that may be involved in tumorigenesis. PMID: 17952061
    8. The alpha-borano or alpha-H on PMEA and PMPA were detrimental to the activity of recombinant human AMP kinases 2 PMID: 18404568
    9. Biallelic mutations in AK2 (adenylate kinase 2) in seven individuals affected with reticular dysgenesis and sensorineural deafness, were identified. PMID: 19043416
    10. The gene encoding the mitochondrial energy metabolism enzyme adenylate kinase 2 (AK2) is mutated in individuals with reticular dysgenesis. PMID: 19043417

    顯示更多

    收起更多

  • 相關疾病：
    Reticular dysgenesis (RDYS)
  • 亞細胞定位：
    Mitochondrion intermembrane space.
  • 蛋白家族：
    Adenylate kinase family, AK2 subfamily
  • 組織特異性：
    Present in most tissues. Present at high level in heart, liver and kidney, and at low level in brain, skeletal muscle and skin. Present in thrombocytes but not in erythrocytes, which lack mitochondria. Present in all nucleated cell populations from blood,
  • 數據庫鏈接：

    HGNC: 362

    OMIM: 103020

    KEGG: hsa:204

    STRING: 9606.ENSP00000346921

    UniGene: Hs.470907



主站蜘蛛池模板： 免费精品国偷自产在线在线| 久久躁狠狠躁夜夜av| 无码少妇a片一区二区三区| 亚洲午夜无码极品久久| 少妇无码精油按摩专区| 精品亚洲成av人在线观看| 性饥渴少妇av无码毛片| 99久热在线精品996热是什么| 亚洲精品久久久久久久久久久| 欧美亚洲精品中文字幕乱码| 亚洲中文字幕永久在线全国| 亚洲精品宾馆在线精品酒店| 国产丰满人妻一区二区| 东北女人啪啪对白| 又粗又黄又硬又爽的免费视频| 成人影院yy111111在线| 久久理论片午夜琪琪电影网| 久草热久草热线频97精品| 欧美丰满熟妇xx猛交| 日本人妻伦在线中文字幕| 国产精品久久无码不卡黑寡妇 | 亚洲成av人在线观看网站| 色婷婷综合中文久久一本| 黑巨人与欧美精品一区| 久久久噜噜噜久久熟女色| 性暴力欧美猛交在线播放| 欧美日韩精品一区二区在线播放 | 国产综合一区二区三区黄页秋霞| 秋霞特色aa大片| 亚洲乱亚洲乱妇24p| 人人妻碰人人免费| 久久久久久久久毛片精品| 少妇久久久久久被弄到高潮| 免费1级a做爰片观看| 国产未成女一区二区| 欧美三级在线播放| 久久久不卡国产精品一区二区 | 久久久久久人妻毛片a片| 中文字幕有码无码av| 欧美s码亚洲码精品m码| 国产又色又爽又黄好看的视频|