在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

AK2 Antibody

  • 中文名稱:
    AK2兔多克隆抗體
  • 貨號:
    CSB-PA001509GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    AK2
  • 別名:
    Adenylate kinase 2 antibody; adenylate kinase 2, mitochondrial antibody; Adenylate kinase isoenzyme 2 antibody; ADK2 antibody; AK 2 antibody; ak2 antibody; ATP AMP transphosphorylase antibody; ATP-AMP transphosphorylase 2 antibody; EC 2.7.4.3 antibody; KAD2_HUMAN antibody; mitochondrial antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat,Zebrafish
  • 免疫原:
    Human AK2
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC,IF
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
  • 基因功能參考文獻:
    1. Genetic variants of AK2 activates tenofovir for HIV therapy. PMID: 29641561
    2. Reticular dysgenesis -patient derived induced pluripotent stem cells can recapitulate disease phenotype which can be rescued by AK2 overexpression. PMID: 29462620
    3. In conclusion, our data suggest that SIRPalpha signaling through SHP-2-PI3K-Akt2 strongly influences osteoblast differentiation from bone marrow stromal cells. PMID: 27422603
    4. AK2 deficiency compromises the mitochondrial energy metabolism required for differentiation of human neutrophil and lymphoid lineages. PMID: 26270350
    5. results suggest that AK2 is an associated activator of DUSP26 and suppresses cell proliferation by FADD dephosphorylation, postulating AK2 as a negative regulator of tumour growth. PMID: 24548998
    6. AK2 is indispensable for neutrophil differentiation, indicating a possible causative link between AK2 deficiency and neutropenia in reticular dysgenesis. PMID: 24587121
    7. These results suggest that, acting in concert with FADD and caspase-10, AK2 mediates a novel intrinsic apoptotic pathway that may be involved in tumorigenesis. PMID: 17952061
    8. The alpha-borano or alpha-H on PMEA and PMPA were detrimental to the activity of recombinant human AMP kinases 2 PMID: 18404568
    9. Biallelic mutations in AK2 (adenylate kinase 2) in seven individuals affected with reticular dysgenesis and sensorineural deafness, were identified. PMID: 19043416
    10. The gene encoding the mitochondrial energy metabolism enzyme adenylate kinase 2 (AK2) is mutated in individuals with reticular dysgenesis. PMID: 19043417

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Reticular dysgenesis (RDYS)
  • 亞細胞定位:
    Mitochondrion intermembrane space.
  • 蛋白家族:
    Adenylate kinase family, AK2 subfamily
  • 組織特異性:
    Present in most tissues. Present at high level in heart, liver and kidney, and at low level in brain, skeletal muscle and skin. Present in thrombocytes but not in erythrocytes, which lack mitochondria. Present in all nucleated cell populations from blood,
  • 數據庫鏈接:

    HGNC: 362

    OMIM: 103020

    KEGG: hsa:204

    STRING: 9606.ENSP00000346921

    UniGene: Hs.470907



主站蜘蛛池模板: 国产午夜福利片| 欧美精品无码一区二区三区| 久久久久女教师免费一区| 亚洲人成网站18禁止无码| 国产乱妇乱子在线播放视频| 青青国产揄拍视频| 亚洲日韩在线a视频在线观看 | 久久精品国产精品亚洲38| 精品av综合导航| 内射口爆少妇麻豆| 成人试看30分钟免费视频| 国产内射xxxxx在线| 国产良妇出轨视频在线观看| 又粗又大又硬又长又爽| 久久www香蕉免费人成| 国产原创av中文在线观看| 亚洲伊人久久成人综合网 | 特黄大片又粗又大又暴| 高清无码一区二区在线观看吞精| 国产精品女上位好爽在线 | 99久热在线精品996热是什么| 风韵丰满熟妇啪啪区老老熟妇 | 色综合色狠狠天天综合网| 18禁超污无遮挡无码网址| 男男又爽又黄又无遮挡网站| 天天躁夜夜躁av天天爽| 爱性久久久久久久久| 国内精品国语自产拍在线观看| 国产98在线 | 欧美| 亚洲精品一区| 亚洲国产精品久久久天堂麻豆宅男| 久久久精品人妻一区二区三区gv| 亚洲熟妇自偷自拍另类| 十八岁以下禁止观看黄下载链接| 久久精品人妻一区二区三区| 中文字幕在线亚洲日韩6页| 久久精品伊人一区二区三区| 亚洲aⅴ天堂av天堂无码麻豆| 中国xxxx做受视频| 欧美人与禽z0zo牲伦交| 精品无码黑人又粗又大又长|