在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. AK2 Antibody

AK2 Antibody

  • 中文名稱：
    AK2兔多克隆抗體
  • 貨號：
    CSB-PA443063
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA443063(AK2 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA443063(AK2 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-7: Human placenta tissue, A549 cells, mouse brain tissue, hepG2 cells, Raji cells, human fetal liver tissue, hela cells, Primary antibody: CSB-PA443063(AK2 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    AK2
  • 別名：
    Adenylate kinase 2 antibody; adenylate kinase 2, mitochondrial antibody; Adenylate kinase isoenzyme 2 antibody; ADK2 antibody; AK 2 antibody; ak2 antibody; ATP AMP transphosphorylase antibody; ATP-AMP transphosphorylase 2 antibody; EC 2.7.4.3 antibody; KAD2_HUMAN antibody; mitochondrial antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human AK2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
  • 基因功能參考文獻：
    1. Genetic variants of AK2 activates tenofovir for HIV therapy. PMID: 29641561
    2. Reticular dysgenesis -patient derived induced pluripotent stem cells can recapitulate disease phenotype which can be rescued by AK2 overexpression. PMID: 29462620
    3. In conclusion, our data suggest that SIRPalpha signaling through SHP-2-PI3K-Akt2 strongly influences osteoblast differentiation from bone marrow stromal cells. PMID: 27422603
    4. AK2 deficiency compromises the mitochondrial energy metabolism required for differentiation of human neutrophil and lymphoid lineages. PMID: 26270350
    5. results suggest that AK2 is an associated activator of DUSP26 and suppresses cell proliferation by FADD dephosphorylation, postulating AK2 as a negative regulator of tumour growth. PMID: 24548998
    6. AK2 is indispensable for neutrophil differentiation, indicating a possible causative link between AK2 deficiency and neutropenia in reticular dysgenesis. PMID: 24587121
    7. These results suggest that, acting in concert with FADD and caspase-10, AK2 mediates a novel intrinsic apoptotic pathway that may be involved in tumorigenesis. PMID: 17952061
    8. The alpha-borano or alpha-H on PMEA and PMPA were detrimental to the activity of recombinant human AMP kinases 2 PMID: 18404568
    9. Biallelic mutations in AK2 (adenylate kinase 2) in seven individuals affected with reticular dysgenesis and sensorineural deafness, were identified. PMID: 19043416
    10. The gene encoding the mitochondrial energy metabolism enzyme adenylate kinase 2 (AK2) is mutated in individuals with reticular dysgenesis. PMID: 19043417

    顯示更多

    收起更多

  • 相關疾病：
    Reticular dysgenesis (RDYS)
  • 亞細胞定位：
    Mitochondrion intermembrane space.
  • 蛋白家族：
    Adenylate kinase family, AK2 subfamily
  • 組織特異性：
    Present in most tissues. Present at high level in heart, liver and kidney, and at low level in brain, skeletal muscle and skin. Present in thrombocytes but not in erythrocytes, which lack mitochondria. Present in all nucleated cell populations from blood,
  • 數據庫鏈接：

    HGNC: 362

    OMIM: 103020

    KEGG: hsa:204

    STRING: 9606.ENSP00000346921

    UniGene: Hs.470907



主站蜘蛛池模板： 黑色丝袜脚足国产在线看| 久久精品国产欧美日韩 | 欧美村妇激情内射| 国语对白刺激精品视频| 最近日本免费观看高清视频| 乱色熟女综合一区二区三区 | 香蕉久久av一区二区三区app| 国产精品欧美成人| 77777_亚洲午夜久久多人| 欧美丰满熟妇xxxxx| 午夜好爽好舒服免费视频| 让少妇爽到高潮视频| 国产精品国产三级国产av主播 | 国产精品爽爽久久久久久| 精品偷自拍另类在线观看| 免费无遮挡很爽很污很黄的网站| 日本免费一区二区三区四区五区| 久久午夜无码鲁丝片午夜精品| 国产69久久精品成人看| 一区二三区国产好的精华液o9| 人妻av无码专区| 免费中文字幕日韩欧美| 丁香婷婷综合久久来来去| 国产成人夜色高潮福利影视| 熟女人妇 成熟妇女系列视频| 日韩久久无码免费毛片软件 | 蜜桃麻豆www久久国产sex| 极品少妇的粉嫩小泬视频| 精品三级av无码一区| 久久人妻xunleige无码| 国产 国语对白 露脸| 人人澡超碰碰97碰碰碰| 日韩爆乳一区二区无码| 国内精品国产三级国产av | 亚洲精品亚洲人成在线下载| 无码一区二区| 忘忧草社区中文字幕www| 日本真人边吃奶边做爽免费视频| 中文字幕人妻互换av久久| 娇小萝被两个黑人用半米长| 久久精品成人免费观看|