在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. AK2 Antibody

AK2 Antibody

  • 中文名稱：
    AK2兔多克隆抗體
  • 貨號：
    CSB-PA001509ESR1HU
  • 規格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: Adenylate kinase 2, mitochondrial antibody at 5μg/ml
      Lane 1: Hela whole cell lysate
      Lane 2: Mouse kidney tissue
      Lane 3: Mouse small intestine tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 27, 26, 23, 15, 25, 22 kDa
      Observed band size: 27 kDa
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA001509ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA001509ESR1HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) AK2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    AK2
  • 別名：
    Adenylate kinase 2 antibody; adenylate kinase 2, mitochondrial antibody; Adenylate kinase isoenzyme 2 antibody; ADK2 antibody; AK 2 antibody; ak2 antibody; ATP AMP transphosphorylase antibody; ATP-AMP transphosphorylase 2 antibody; EC 2.7.4.3 antibody; KAD2_HUMAN antibody; mitochondrial antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human Adenylate kinase 2, mitochondrial protein (1-232AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
  • 基因功能參考文獻：
    1. Genetic variants of AK2 activates tenofovir for HIV therapy. PMID: 29641561
    2. Reticular dysgenesis -patient derived induced pluripotent stem cells can recapitulate disease phenotype which can be rescued by AK2 overexpression. PMID: 29462620
    3. In conclusion, our data suggest that SIRPalpha signaling through SHP-2-PI3K-Akt2 strongly influences osteoblast differentiation from bone marrow stromal cells. PMID: 27422603
    4. AK2 deficiency compromises the mitochondrial energy metabolism required for differentiation of human neutrophil and lymphoid lineages. PMID: 26270350
    5. results suggest that AK2 is an associated activator of DUSP26 and suppresses cell proliferation by FADD dephosphorylation, postulating AK2 as a negative regulator of tumour growth. PMID: 24548998
    6. AK2 is indispensable for neutrophil differentiation, indicating a possible causative link between AK2 deficiency and neutropenia in reticular dysgenesis. PMID: 24587121
    7. These results suggest that, acting in concert with FADD and caspase-10, AK2 mediates a novel intrinsic apoptotic pathway that may be involved in tumorigenesis. PMID: 17952061
    8. The alpha-borano or alpha-H on PMEA and PMPA were detrimental to the activity of recombinant human AMP kinases 2 PMID: 18404568
    9. Biallelic mutations in AK2 (adenylate kinase 2) in seven individuals affected with reticular dysgenesis and sensorineural deafness, were identified. PMID: 19043416
    10. The gene encoding the mitochondrial energy metabolism enzyme adenylate kinase 2 (AK2) is mutated in individuals with reticular dysgenesis. PMID: 19043417

    顯示更多

    收起更多

  • 相關疾病：
    Reticular dysgenesis (RDYS)
  • 亞細胞定位：
    Mitochondrion intermembrane space.
  • 蛋白家族：
    Adenylate kinase family, AK2 subfamily
  • 組織特異性：
    Present in most tissues. Present at high level in heart, liver and kidney, and at low level in brain, skeletal muscle and skin. Present in thrombocytes but not in erythrocytes, which lack mitochondria. Present in all nucleated cell populations from blood,
  • 數據庫鏈接：

    HGNC: 362

    OMIM: 103020

    KEGG: hsa:204

    STRING: 9606.ENSP00000346921

    UniGene: Hs.470907



主站蜘蛛池模板： 国产福利自产拍| 成人免费直播| 97久久久人妻一区精品| 鲁丝一区二区三区免费| 蜜桃成人无码区免费视频网站| 午夜福利啪啪无遮挡免费| 亚洲国产成人精品无码区四虎 | 饥渴少妇av无码影片| 日韩人妻无码精品二专区| 国产精品久久久久久久久久免费| 5858s亚洲色大成网站www| 九一九色国产| 高清破外女出血av毛片| 亚洲欧洲精品无码av| 国产精品丰臀| 波多野结衣的av一区二区三区| 国产日产欧产精品精品ai| 久久国产福利播放| 99精品久久精品一区二区| 精品人妻系列无码人妻不卡| 人妻av中文字幕一区二区三区| 无码大潮喷水在线观看| 欧美成人午夜精品久久久| 国产av无码专区亚洲精品| 99re8精品视频热线观看| 国产高清在线精品一区免费| 人妻无码久久精品人妻| 亚洲女人自熨在线视频| 无码精品a∨在线观看十八禁| 亚洲国产精品尤物yw在线观看| 日本大片免a费观看视频三区| 亚洲欧洲日产韩国无码| 日韩v亚洲v欧美v精品综合| 国产无遮挡裸体免费视频在线观看| 97夜夜澡人人爽人人喊a| 国内偷窥一区二区三区视频| 欧美日本韩国亚洲| 日韩精品一区二区三区中文| 美女mm131午夜福利在线| 一道本在线伊人蕉无码| 国产精品久久久亚洲|