在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ABL2 Antibody

ABL2 Antibody

  • 中文名稱：
    ABL2兔多克隆抗體
  • 貨號：
    CSB-PA001106LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: U87 whole cell lysate, U251 whole cell lysate
      All lanes: ABL2 antibody at 4µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 129, 125, 127, 115, 118, 116, 117, 61 kDa
      Observed band size: 115 kDa
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) ABL2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Abelson murine leukemia viral oncogene homolog 2 antibody; Abelson related gene protein antibody; Abelson tyrosine-protein kinase 2 antibody; Abelson-related gene protein antibody; ABL2 antibody; ABL2_HUMAN antibody; ABLL antibody; ARG antibody; Tyrosine kinase ARG antibody; Tyrosine protein kinase ABL2 antibody; Tyrosine-protein kinase ARG antibody; v abl Abelson murine leukemia viral oncogene homolog 2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Tyrosine-protein kinase ABL2 protein (862-1064AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，ABL2 Antibody (CSB-PA001106LA01HU)，的標記方式是Non-conjugated。對于ABL2 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA001106LB01HU ABL2 Antibody, HRP conjugated ELISA
    FITC CSB-PA001106LC01HU ABL2 Antibody, FITC conjugated
    Biotin CSB-PA001106LD01HU ABL2 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.
  • 基因功能參考文獻：
    1. These data evidence a new specific involvement of Arg kinase into the regulation of TGF-beta1 expression in tubular cells under high-glucose conditions. PMID: 27298228
    2. Q112H mutation hinders the ability of the protein to interact with Abl kinase, leading to defective tyrosine phosphorylation and a resultant defect in respiration PMID: 27913209
    3. the ETV6/ARG oncoprotein contributes to autonomous cell growth by compensating for the requirement of growth factor through activating STAT5 signaling, which leads to the up-regulation of c-Myc. PMID: 25373509
    4. Two distinct interfaces mediate direct binding of integrin beta1 with Arg in vitro and in cells and promote Arg kinase activation. PMID: 25694433
    5. Knockdown of ABL2 promoted cell invasion and migration and we identified miR-20a-induced cell invasion and migration can be rescued by ABL2. PMID: 24464651
    6. Data shows that c-Abl and Arg induce NM23-H1 degradation by increasing expression and activation of cathepsin L and B, which directly cleave NM23-H1 in the lysosome. PMID: 24096484
    7. data provide evidence that Aurora A, AMPK, ABL and CDKs are functionally integrated into human cytomegalovirus (HCMV) replication; inhibition of AMPK and ABL kinases exerted a negative effect, inhibition of Aurora A kinase a slightly positive effect on HCMV replication PMID: 23648710
    8. Beta1 integrin regulates Arg to promote invadopodial maturation and matrix degradation. PMID: 23552693
    9. ARG isoforms's cellular location modulate cell morphology, motility, the cytoskeleton, and focal adhesions. PMID: 23707396
    10. Arg acts as a switch in metastatic cancer cells that governs the decision to 'grow or go' (divide or invade). PMID: 22777352
    11. Knockout mutation of p27-p55 operon in Mycobacterium bovis severely decreased the virulence of the bacteria when assessed in a progressive model of pulmonary tuberculosis in Balb/c mice. PMID: 21543883
    12. Our findings suggest a novel mechanism by which an EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion PMID: 21257711
    13. The Arg tyrosine kinase regulated lysosomal degradation of antiapoptotic Gal3 may provide one of the important arms in Arg tyrosine kinase dependent antiapoptotic pathways. PMID: 20150913
    14. A 35-bp insertion in the BCR-ABL2 gene is associated with resistance to tyrosine kinase inhibitors, but sensitivity to omacetaxine in chronic myelogenous leukemia. PMID: 20448119
    15. Results describe the NMR structure of human Arg F-actin-binding domain. PMID: 20077570
    16. The highest Arg transcript and protein levels are in the mature B cells. PMID: 12220663
    17. High Arg expression is correlated with thymoma stage PMID: 15679048
    18. several critical domains within TEL/ARG necessary for function PMID: 15729383
    19. ABL2/ARG is a novel mediator of SEMA3F-induced RhoA inactivation and collapsing activity. PMID: 18660502

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, ABL subfamily
  • 組織特異性：
    Widely expressed.
  • 數據庫鏈接：

    HGNC: 77

    OMIM: 164690

    KEGG: hsa:27

    STRING: 9606.ENSP00000427562

    UniGene: Hs.159472



主站蜘蛛池模板： 老司机深夜18禁污污网站| 最新精品国偷自产在线美女足| 久久久久久免费毛片精品| 丰满少妇被猛烈进入av久久| 性色av极品无码专区亚洲| 国产末成年女av片一区二区| 狠狠色噜噜狠狠狠8888在| 人妻少妇精品无码专区| 婷婷丁香五月缴情视频| 97久久超碰国产精品最新 | 九九久re8在线精品视频| 插我舔内射18免费视频| 国产欧美va天堂在线观看视频| 无码人妻精品一区二区三区免费 | 久久综合五月丁香六月丁香 | 少妇高潮一区二区三区99| 男女做爰猛烈啪啪吃奶伸舌头下载| 国产精品成人国产乱| 欧美奶涨边摸边做爰视频| 越南女子杂交内射bbwxz| 香蕉精品亚洲二区在线观看| 欧美乱大交xxxxx潮喷l头像| 少妇久久久久久人妻无码| 成av人片在线观看www| a国产一区二区免费入口| 国产精品久久久久久av福利| 成人午夜电影福利免费| 欧美丰满大乳大屁股流白浆| 国产欧美va欧美va香蕉在线| 久久九九兔免费精品6| 18禁止进入1000部高潮网站| 国产av熟女一区二区三区| 色综合视频一区二区三区44| 果冻传媒mv免费播放在线观看| 日韩精品人妻系列无码专区免费| 欧美黑人又粗又大久久久| 久久影院午夜伦手机不四虎卡| 小小拗女性bbwxxxx国产| 亚洲欧洲无码av电影在线观看 | 亚洲精品国偷自产在线99人热| 99久久久无码国产精品动漫|