在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ABL2 Antibody, HRP conjugated

ABL2 Antibody, HRP conjugated

  • 中文名稱：
    ABL2兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA001106LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) ABL2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Abelson murine leukemia viral oncogene homolog 2 antibody; Abelson related gene protein antibody; Abelson tyrosine-protein kinase 2 antibody; Abelson-related gene protein antibody; ABL2 antibody; ABL2_HUMAN antibody; ABLL antibody; ARG antibody; Tyrosine kinase ARG antibody; Tyrosine protein kinase ABL2 antibody; Tyrosine-protein kinase ARG antibody; v abl Abelson murine leukemia viral oncogene homolog 2 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Tyrosine-protein kinase ABL2 protein (862-1064AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.
  • 基因功能參考文獻：
    1. These data evidence a new specific involvement of Arg kinase into the regulation of TGF-beta1 expression in tubular cells under high-glucose conditions. PMID: 27298228
    2. Q112H mutation hinders the ability of the protein to interact with Abl kinase, leading to defective tyrosine phosphorylation and a resultant defect in respiration PMID: 27913209
    3. the ETV6/ARG oncoprotein contributes to autonomous cell growth by compensating for the requirement of growth factor through activating STAT5 signaling, which leads to the up-regulation of c-Myc. PMID: 25373509
    4. Two distinct interfaces mediate direct binding of integrin beta1 with Arg in vitro and in cells and promote Arg kinase activation. PMID: 25694433
    5. Knockdown of ABL2 promoted cell invasion and migration and we identified miR-20a-induced cell invasion and migration can be rescued by ABL2. PMID: 24464651
    6. Data shows that c-Abl and Arg induce NM23-H1 degradation by increasing expression and activation of cathepsin L and B, which directly cleave NM23-H1 in the lysosome. PMID: 24096484
    7. data provide evidence that Aurora A, AMPK, ABL and CDKs are functionally integrated into human cytomegalovirus (HCMV) replication; inhibition of AMPK and ABL kinases exerted a negative effect, inhibition of Aurora A kinase a slightly positive effect on HCMV replication PMID: 23648710
    8. Beta1 integrin regulates Arg to promote invadopodial maturation and matrix degradation. PMID: 23552693
    9. ARG isoforms's cellular location modulate cell morphology, motility, the cytoskeleton, and focal adhesions. PMID: 23707396
    10. Arg acts as a switch in metastatic cancer cells that governs the decision to 'grow or go' (divide or invade). PMID: 22777352
    11. Knockout mutation of p27-p55 operon in Mycobacterium bovis severely decreased the virulence of the bacteria when assessed in a progressive model of pulmonary tuberculosis in Balb/c mice. PMID: 21543883
    12. Our findings suggest a novel mechanism by which an EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion PMID: 21257711
    13. The Arg tyrosine kinase regulated lysosomal degradation of antiapoptotic Gal3 may provide one of the important arms in Arg tyrosine kinase dependent antiapoptotic pathways. PMID: 20150913
    14. A 35-bp insertion in the BCR-ABL2 gene is associated with resistance to tyrosine kinase inhibitors, but sensitivity to omacetaxine in chronic myelogenous leukemia. PMID: 20448119
    15. Results describe the NMR structure of human Arg F-actin-binding domain. PMID: 20077570
    16. The highest Arg transcript and protein levels are in the mature B cells. PMID: 12220663
    17. High Arg expression is correlated with thymoma stage PMID: 15679048
    18. several critical domains within TEL/ARG necessary for function PMID: 15729383
    19. ABL2/ARG is a novel mediator of SEMA3F-induced RhoA inactivation and collapsing activity. PMID: 18660502

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, ABL subfamily
  • 組織特異性：
    Widely expressed.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 77

    OMIM: 164690

    KEGG: hsa:27

    STRING: 9606.ENSP00000427562

    UniGene: Hs.159472



主站蜘蛛池模板： 久9视频这里只有精品| 大香伊蕉在人线国产最新75| 免费国产在线精品一区不卡| 国产精品福利一区二区久久| 国产三级精品三级| 国产精品sp调教打屁股| 国产精品美脚玉足脚交欧美| a 'v片欧美日韩在线| 久久―日本道色综合久久 | 天天综合亚洲色在线精品| 久久久久四虎精品免费入口| 国产精品调教视频一区| 香蕉av777xxx色综合一区| 色综合色狠狠天天综合色| 国产粉嫩小泬在线观看泬| 国产精品无码翘臀在线看 | 好想被狂躁无码视频在线观看| 香港三日本三级少妇三级66| 唐人社导航福利精品| 亚洲精品国产精品乱码不卡| 国产伦人人人人人人性| 国产精品久久自在自线不| 乱人伦人妻中文字幕无码| 亚洲三区在线观看内射后入| 在线精品亚洲一区二区| 狠狠躁天天躁中文字幕无码| 人人妻人人澡人人爽人人dvd| 亚洲国产成在人网站天堂| 西西人体www44rt大胆高清| 欧美精品在线观看| 免费三级现频在线观看免费| 日韩精品无码久久久久久| 男女免费观看在线爽爽爽视频| 中文国产成人精品久久不卡| 女人18毛片水真多免费看| 欧美性video高清精品| 欧美亚洲国产片在线播放| 中文区中文字幕免费看| 影音先锋在线亚洲网站| 精品综合久久久久久97| 国产免费又色又爽粗视频|