在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ABL2 Antibody

ABL2 Antibody

  • 中文名稱：
    ABL2兔多克隆抗體
  • 貨號：
    CSB-PA119696
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA119696(ABL2 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA119696(ABL2 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hela cells, Jurkat cells, Primary antibody: CSB-PA119696(ABL2 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Abelson murine leukemia viral oncogene homolog 2 antibody; Abelson related gene protein antibody; Abelson tyrosine-protein kinase 2 antibody; Abelson-related gene protein antibody; ABL2 antibody; ABL2_HUMAN antibody; ABLL antibody; ARG antibody; Tyrosine kinase ARG antibody; Tyrosine protein kinase ABL2 antibody; Tyrosine-protein kinase ARG antibody; v abl Abelson murine leukemia viral oncogene homolog 2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human ABL2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.
  • 基因功能參考文獻：
    1. These data evidence a new specific involvement of Arg kinase into the regulation of TGF-beta1 expression in tubular cells under high-glucose conditions. PMID: 27298228
    2. Q112H mutation hinders the ability of the protein to interact with Abl kinase, leading to defective tyrosine phosphorylation and a resultant defect in respiration PMID: 27913209
    3. the ETV6/ARG oncoprotein contributes to autonomous cell growth by compensating for the requirement of growth factor through activating STAT5 signaling, which leads to the up-regulation of c-Myc. PMID: 25373509
    4. Two distinct interfaces mediate direct binding of integrin beta1 with Arg in vitro and in cells and promote Arg kinase activation. PMID: 25694433
    5. Knockdown of ABL2 promoted cell invasion and migration and we identified miR-20a-induced cell invasion and migration can be rescued by ABL2. PMID: 24464651
    6. Data shows that c-Abl and Arg induce NM23-H1 degradation by increasing expression and activation of cathepsin L and B, which directly cleave NM23-H1 in the lysosome. PMID: 24096484
    7. data provide evidence that Aurora A, AMPK, ABL and CDKs are functionally integrated into human cytomegalovirus (HCMV) replication; inhibition of AMPK and ABL kinases exerted a negative effect, inhibition of Aurora A kinase a slightly positive effect on HCMV replication PMID: 23648710
    8. Beta1 integrin regulates Arg to promote invadopodial maturation and matrix degradation. PMID: 23552693
    9. ARG isoforms's cellular location modulate cell morphology, motility, the cytoskeleton, and focal adhesions. PMID: 23707396
    10. Arg acts as a switch in metastatic cancer cells that governs the decision to 'grow or go' (divide or invade). PMID: 22777352
    11. Knockout mutation of p27-p55 operon in Mycobacterium bovis severely decreased the virulence of the bacteria when assessed in a progressive model of pulmonary tuberculosis in Balb/c mice. PMID: 21543883
    12. Our findings suggest a novel mechanism by which an EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion PMID: 21257711
    13. The Arg tyrosine kinase regulated lysosomal degradation of antiapoptotic Gal3 may provide one of the important arms in Arg tyrosine kinase dependent antiapoptotic pathways. PMID: 20150913
    14. A 35-bp insertion in the BCR-ABL2 gene is associated with resistance to tyrosine kinase inhibitors, but sensitivity to omacetaxine in chronic myelogenous leukemia. PMID: 20448119
    15. Results describe the NMR structure of human Arg F-actin-binding domain. PMID: 20077570
    16. The highest Arg transcript and protein levels are in the mature B cells. PMID: 12220663
    17. High Arg expression is correlated with thymoma stage PMID: 15679048
    18. several critical domains within TEL/ARG necessary for function PMID: 15729383
    19. ABL2/ARG is a novel mediator of SEMA3F-induced RhoA inactivation and collapsing activity. PMID: 18660502

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, ABL subfamily
  • 組織特異性：
    Widely expressed.
  • 數據庫鏈接：

    HGNC: 77

    OMIM: 164690

    KEGG: hsa:27

    STRING: 9606.ENSP00000427562

    UniGene: Hs.159472



主站蜘蛛池模板： 国产情侣激情在线视频| 中文字幕人妻熟女人妻a片| 国产自偷自偷免费一区| mm1313亚洲国产精品无码试看| 动漫av纯肉无码免费播放| 综合激情丁香久久狠狠| 嫩b人妻精品一区二区三区| 国产真实乱对白精彩久久老熟妇女| 国精产品一区一区三区| 亚洲色无码中文字幕手机在线| 国产精品三级av及在线观看| 偷偷要色偷偷中文无码| 国产高潮国产高潮久久久| 欧美成人片一区二区三区| 国产小受呻吟gv视频在线观看| 婷婷综合久久狠狠色99h| 天堂va欧美va亚洲va好看va| 一边捏奶头一边啪高潮视频| 浴室人妻的情欲hd三级| 欧美成年视频在线观看| 久久精品无码专区免费| 日本xxxxx片免费观看喷水| 国产成人年无码av片在线观看| 永久免费男同av无码入口| 久久综合一色综合久久小蛇| 伊人蕉久中文字幕无码专区 | 人妻少妇偷人无码视频| 一本久久a久久免费精品不卡| 色猫咪av在线观看| 欧美性生交xxxxx久久久| 乱熟女高潮一区二区在线| 极品白嫩的小少妇| 永久免费无码网站在线观看| 亚洲欧洲精品成人久久曰影片| 五月天天天综合精品无码| 无码熟妇人妻av在线网站| 大香伊蕉日本一区二区| 国内精品国语自产拍在线观看| 日韩精品一区二区av在线观看| 5x性社区免费视频播| 亚洲精品成人a在线观看|