在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ABL2 Antibody

ABL2 Antibody

  • 中文名稱：
    ABL2兔多克隆抗體
  • 貨號：
    CSB-PA005570
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of AD293 cells using Arg Polyclonal Antibody.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Abelson murine leukemia viral oncogene homolog 2 antibody; Abelson related gene protein antibody; Abelson tyrosine-protein kinase 2 antibody; Abelson-related gene protein antibody; ABL2 antibody; ABL2_HUMAN antibody; ABLL antibody; ARG antibody; Tyrosine kinase ARG antibody; Tyrosine protein kinase ABL2 antibody; Tyrosine-protein kinase ARG antibody; v abl Abelson murine leukemia viral oncogene homolog 2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Arg.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.
  • 基因功能參考文獻：
    1. These data evidence a new specific involvement of Arg kinase into the regulation of TGF-beta1 expression in tubular cells under high-glucose conditions. PMID: 27298228
    2. Q112H mutation hinders the ability of the protein to interact with Abl kinase, leading to defective tyrosine phosphorylation and a resultant defect in respiration PMID: 27913209
    3. the ETV6/ARG oncoprotein contributes to autonomous cell growth by compensating for the requirement of growth factor through activating STAT5 signaling, which leads to the up-regulation of c-Myc. PMID: 25373509
    4. Two distinct interfaces mediate direct binding of integrin beta1 with Arg in vitro and in cells and promote Arg kinase activation. PMID: 25694433
    5. Knockdown of ABL2 promoted cell invasion and migration and we identified miR-20a-induced cell invasion and migration can be rescued by ABL2. PMID: 24464651
    6. Data shows that c-Abl and Arg induce NM23-H1 degradation by increasing expression and activation of cathepsin L and B, which directly cleave NM23-H1 in the lysosome. PMID: 24096484
    7. data provide evidence that Aurora A, AMPK, ABL and CDKs are functionally integrated into human cytomegalovirus (HCMV) replication; inhibition of AMPK and ABL kinases exerted a negative effect, inhibition of Aurora A kinase a slightly positive effect on HCMV replication PMID: 23648710
    8. Beta1 integrin regulates Arg to promote invadopodial maturation and matrix degradation. PMID: 23552693
    9. ARG isoforms's cellular location modulate cell morphology, motility, the cytoskeleton, and focal adhesions. PMID: 23707396
    10. Arg acts as a switch in metastatic cancer cells that governs the decision to 'grow or go' (divide or invade). PMID: 22777352
    11. Knockout mutation of p27-p55 operon in Mycobacterium bovis severely decreased the virulence of the bacteria when assessed in a progressive model of pulmonary tuberculosis in Balb/c mice. PMID: 21543883
    12. Our findings suggest a novel mechanism by which an EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion PMID: 21257711
    13. The Arg tyrosine kinase regulated lysosomal degradation of antiapoptotic Gal3 may provide one of the important arms in Arg tyrosine kinase dependent antiapoptotic pathways. PMID: 20150913
    14. A 35-bp insertion in the BCR-ABL2 gene is associated with resistance to tyrosine kinase inhibitors, but sensitivity to omacetaxine in chronic myelogenous leukemia. PMID: 20448119
    15. Results describe the NMR structure of human Arg F-actin-binding domain. PMID: 20077570
    16. The highest Arg transcript and protein levels are in the mature B cells. PMID: 12220663
    17. High Arg expression is correlated with thymoma stage PMID: 15679048
    18. several critical domains within TEL/ARG necessary for function PMID: 15729383
    19. ABL2/ARG is a novel mediator of SEMA3F-induced RhoA inactivation and collapsing activity. PMID: 18660502

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, ABL subfamily
  • 組織特異性：
    Widely expressed.
  • 數據庫鏈接：

    HGNC: 77

    OMIM: 164690

    KEGG: hsa:27

    STRING: 9606.ENSP00000427562

    UniGene: Hs.159472



主站蜘蛛池模板： 粗大猛烈进出高潮视频| 国产在线观看精品一区二区三区| 日本国产成人国产在线播放| 女高中生自慰污污网站| 午夜不卡av免费| 亚洲国产精品一区二区久久hs | 久久精品av一区二区免费| 大肉大捧一进一出好爽视频mba| 无码av无码天堂资源网| 成人免费b2b网站大全在线| 中国少妇内射xxxxx-百度| 久久无码专区国产精品| 中文天堂在线www| 免费人成视频在线观看播放网站| 亚洲 卡通 欧美 制服 中文| 亚洲小说春色综合另类| 国产精品亚洲专区无码不卡| av狼友无码国产在线观看| 久久久综综合色一本伊人| 亚洲 欧美 变态 另类 综合| 亚洲乱码中文字幕久久孕妇黑人 | 色欧美片视频在线观看| 国产久热精品无码激情 | 亚洲 欧洲 日韩 综合av| 天天做天天摸天天爽天天爱| 久久影视久久午夜| 天天躁夜夜躁天干天干2020| 欧美精品一区二区黄a片| 亚洲国产av无码精品无广告| 国产公妇仑乱在线观看| 欧美z0zo人禽交免费观看99| 情侣黄网站免费看| 久久国内精品自在自线| 亚洲精品无码久久久久av麻豆 | 亚洲另类无码专区丝袜| 九九99精品久久久久久综合| 天天天天躁天天爱天天碰2018| 精品视频一区二区三区在线观看 | 青青视频免费观看免费| 日本精品人妻无码77777| 三上悠亚精品一区二区久久|