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  4. Human monocyte chemotactic protein 4,MCP-4 ELISA kit

Human monocyte chemotactic protein 4,MCP-4 ELISA kit

  • 中文名稱：
    人單核細(xì)胞趨化蛋白4(MCP-4/CCL13)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-E09762h
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人單核細(xì)胞趨化蛋白4(MCP-4/CCL13)酶聯(lián)免疫試劑盒（CSB-E09762h）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿.樣本中的CCL13含量。CCL13是一個(gè)值得關(guān)注的靶點(diǎn)。它屬于趨化因子家族，在炎癥反應(yīng)、免疫調(diào)節(jié)等生理過(guò)程中發(fā)揮作用。研究聚焦于其與疾病發(fā)生發(fā)展機(jī)制的關(guān)聯(lián)，如在某些炎癥性疾病、腫瘤中，CCL13可能參與細(xì)胞遷移、侵襲等，有望成為治療干預(yù)靶點(diǎn)。試劑盒檢測(cè)范圍為39 pg/ml-2500 pg/ml.，靈敏度為9.75 pg/ml.。產(chǎn)品適用于體外研究領(lǐng)域，包括炎癥機(jī)制探索、疾病模型建立、藥物干預(yù)效果評(píng)估等基礎(chǔ)科研場(chǎng)景，例如通過(guò)檢測(cè)不同實(shí)驗(yàn)條件下生物樣本中MCP - 4/CCL13的動(dòng)態(tài)變化，揭示其在免疫調(diào)節(jié)網(wǎng)絡(luò)中的作用機(jī)制。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書(shū)。
  • 別名：
    C-C motif chemokine 13 ELISA Kit; CCL13 ELISA Kit; CCL13_HUMAN ELISA Kit; Chemokine (C C motif) ligand 13 ELISA Kit; CK beta 10 ELISA Kit; CK-beta-10 ELISA Kit; CKb10 ELISA Kit; MCP-4 ELISA Kit; MGC17134 ELISA Kit; Monocyte chemoattractant protein 4 ELISA Kit; Monocyte chemotactic protein 4 ELISA Kit; NCC 1 ELISA Kit; NCC-1 ELISA Kit; NCC1 ELISA Kit; New CC chemokine 1 ELISA Kit; SCYA13 ELISA Kit; SCYL1 ELISA Kit; short chain ELISA Kit; Small inducible cytokine A13 precursor ELISA Kit; Small inducible cytokine subfamily A (Cys Cys) member 13 ELISA Kit; Small-inducible cytokine A13 ELISA Kit
  • 縮寫(xiě)：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates.
  • 檢測(cè)范圍：
    39 pg/ml-2500 pg/ml.
  • 靈敏度：
    9.75 pg/ml.
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens.
  • 基因功能參考文獻(xiàn)：
    1. CCL13 expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
    2. CCL13 levels in serum and synovial fluid may serve as a biomarker for the progression of osteoarthritis. PMID: 25654294
    3. CCL13 is an antimicrobial protein with bacteriocidal activity against E. coli. PMID: 12949249
    4. Data suggest that CCL13 binds to several chemokine receptors (CCR1, CCR2, and CCR3), allowing CCL13 to elicit different effects on target cells of immune system. CCL13 is involved in pathology of chronic inflammatory/autoimmune diseases. [REVIEW] PMID: 23846739
    5. MCP-4 and hsCRP may be the markers linking chronic inflammation in obesity and periodontal disease. PMID: 23375121
    6. E(2) has adverse effects on the pathogenesis of RA as a result of unregulated cell death, increased TNF-alpha-induced MMP-3 production, and CCL13 overproduction, subsequently resulting in the disease progression of RA. PMID: 22393877
    7. Findings suggest that the pro-atherogenic effects of CCR2 may not be restricted to interaction with MCP-1, but could also involve activation by MCP-4, being an inflammatory link between platelet and monocyte activation. PMID: 20139115
    8. Data suggest that the monocyte chemoattractant protein-4 core promoter YY-1 binding motif is functional, and modulates the transcriptional regulation of the MCP-4 gene. PMID: 12805085
    9. The study was undertaken to understand the relationship between the functional proteomics of receptor-Ck and developmental stages of human atherosclerotic aortic wall. PMID: 14560935
    10. MCP-4 may be a critical molecule that links obesity and chronic inflammation. PMID: 16855189
    11. The Th2 cytokine IL-4 preferentially stimulated MCP-4 expression. PMID: 17541284
    12. interferon-gamma with IL-1beta/TNF-alpha activates the production of CCL13 from chondrocytes in RA joints; secreted CCL13 enhances fibroblast-like synoviocyte proliferation by activating the extracellular signal-regulated MAP kinases cascade PMID: 17824960
    13. TLR2, 3, 4 and 5 ligands, but not TLR7/8 or 9 ligands, synergized with IL-4 to induce the production of MCP-4 in nasal polyp fibroblasts. PMID: 17851891
    14. CCL13 and HSPC159 mRNA expressions in PBMC are up-regulated specifically in MCNS patients during the nephrosis phase. PMID: 18219197
    15. Oncostatin M can strongly up-regulate the expression of CCL13, a chemokine recently identified in the synovial fluid of patients with rheumatoid arthritis. PMID: 19565514

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine beta (chemokine CC) family
  • 組織特異性：
    Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph node. Low levels seen in the pulmonary artery smooth muscle cells.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 10611

    OMIM: 601391

    KEGG: hsa:6357

    STRING: 9606.ENSP00000225844

    UniGene: Hs.414629



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