在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human C-X-C motif chemokine 17 protein (CXCL17) (Active)

In Stock
  • 中文名稱:
    Recombinant Human C-X-C motif chemokine 17 protein(CXCL17) (Active)
  • 貨號:
    CSB-AP000781HU
  • 規格:
    ¥852
  • 圖片:
  • 其他:

產品詳情

  • 純度:
    >96% as determined by SDS-PAGE.
  • 內毒素:
    Less than 1.0 EU/μg as determined by LAL method.
  • 生物活性:
    Fully biologically active when compared to standard. The ED50 as determined by its ability to induce VEGF expression using murine endothelial cells is less than 5.0 μg/ml, corresponding to a specific activity of >200 IU/mg.
  • 基因名:
    CXCL17
  • Uniprot No.:
  • 別名:
    CXCL17; VCC1; UNQ473/PRO842C-X-C motif chemokine 17; 6-Cys CXCL17; Dendritic cell and monocyte chemokine-like protein; DMC; VEGF coregulated chemokine 1) [Cleaved into: 4-Cys CXCL17]
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 來源:
    E.Coli
  • 分子量:
    11.5 kDa
  • 表達區域:
    22-119aa
  • 氨基酸序列
    SSLNPGVARG HRDRGQASRR WLQEGGQECE CKDWFLRAPR RKFMTVSGLP KKQCPCDHFK GNVKKTRHQR HHRKPNKHSR ACQQFLKQCQ LRSFALPL
  • 蛋白標簽:
    Tag-Free
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4, with 3 % Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    5-10 business days
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells. Plays a role in angiogenesis and possibly in the development of tumors. Acts as an anti-inflammatory in the stomach. May play a role in the innate defense against infections. Activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions.; seems exhibit much higher chemoattractant potency on monocytes and macrophages than 6-Cys CXCL17.
  • 基因功能參考文獻:
    1. High Lymph node CXCL17 messenger RNA is associated with colon cancer. PMID: 30198422
    2. High expression of CXCL17 correlates with shorter overall survival of breast cancer patients.CXCL17 interacts with CXCR8 in breast cancer cells. PMID: 28943434
    3. CXCL17 attenuates Imiquimod -induced psoriasis-like skin inflammation by recruiting myeloid-derived suppressor cells and regulatory T cells , which may be important for regulating excessive inflammation in psoriasis skin. PMID: 28389593
    4. This article shows that GPR35 is the receptor of CXCL17. PMID: 25411203
    5. CXCL17 production correlated with adverse immune infiltration and might be an important target for anti-HCC therapies. PMID: 25303284
    6. We conclude that CXCL17 is an antimicrobial mucosal chemokine that may play a role in the pathogenesis of interstitial lung diseases PMID: 22611239
    7. these results suggest that VCC-1 is involved in cisplatin-induced apoptosis of HepG2 cells, and also provides some evidence for VCC-1 as a potential cellular target for chemotherapy. PMID: 22425983
    8. An Fc-fusion protein of 35kDa with a modified human immunoglobulin IgG1 Fc domain is capable of inhibiting CC chemokine-induced calcium flux, chemotaxis, and beta-arrestin recruitment in primary macrophages and transfected cells. PMID: 21586597
    9. Immune surveillance occurs during the early intraepithelial stages of human pancreatic carcinogenesis and is mediated by expression of CXCL17 and ICAM2. PMID: 20955708
    10. DMC induces migration of monocytes and immature dendritic cells. Expression studies show that DMC is constitutively expressed in lung, suggesting a potential role for DMC in recruiting monocytes and dendritic cells from blood into lung parenchyma PMID: 16455961
    11. VCC1 plays a role in angiogenesis and possibly in the development of tumors in some tissue types PMID: 16989774
    12. These results strongly suggest that VCC-1 plays an important role in hepatocellular carcinoma cell invasion and tumor growth. PMID: 19657564

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    Intercrine alpha (chemokine CxC) family
  • 組織特異性:
    Detected in trachea, stomach, lung and skeletal muscle. Detected in intestine and in normal and asthmatic lung (at protein level). Breast tumors showed 3- to 24-fold up-regulation.
  • 數據庫鏈接:

    HGNC: 19232

    OMIM: 611387

    KEGG: hsa:284340

    STRING: 9606.ENSP00000472467

    UniGene: Hs.445586



主站蜘蛛池模板: 国产毛片久久久久久国产毛片| 午夜内射中出视频| 欧洲国产精品无码专区影院| 任我爽橹在线精品视频| 精品久久久无码人妻中文字幕豆芽| 国精产品一区一区三区mba下载| 亚洲中文字幕无码一区在线| 中国熟妇浓毛hdsex| 成人做爰高潮片免费视频| 国产午夜成人免费看片app | 天天躁日日躁狠狠躁免费麻豆| 四虎影成人精品a片| 在线综合亚洲欧美日韩| 52熟女露脸国语对白视频| 妲己丰满人熟妇大尺度人体艺| 人妻无码第一区二区三区| 少妇被粗大的猛进69视频| 亚洲影院天堂中文av色| 国内精品久久久久影院网站| 我的性奴的肉玩具1一17心奴| 乱中年女人伦| 中文字幕人妻熟女人妻洋洋| 中文字幕无码精品三级在线电影| 天堂最新版在线www官网中文地址| 国产av无码国产av毛片| 男人av无码天堂| 国产精品久久综合免费| 午夜免费啪在线观看视频| 国产美女在线精品免费观看网址| 国产乱码精品一品二品| 日韩精品无码中文字幕一区二区| 国产99久久久国产无需播放器| 精品无码国产一区二区三区av| 国产精品久久久久野外| 欧美 国产 亚洲视频| 无码大潮喷水在线观看| 综合人妻久久一区二区精品| 国产第一页屁屁影院| 好日子在线观看视频大全免费动漫| 性暴力欧美猛交在线播放| 少妇人妻互换不带套|