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PDPN

PDPN全稱為平足蛋白(Podoplanin),又名Aggrus、T1-alpha,是一種跨膜糖蛋白。PDPN通過與血小板C型凝集素樣受體CLEC-2結(jié)合,在腫瘤微環(huán)境中誘導(dǎo)血小板活化,促進(jìn)癌細(xì)胞轉(zhuǎn)移和血管生成。其在膠質(zhì)母細(xì)胞瘤、肺癌及頭頸部鱗癌中高表達(dá),通過激活PI3K/Akt通路增強腫瘤細(xì)胞侵襲性,同時參與調(diào)控淋巴管發(fā)育異常相關(guān)的疾病。臨床數(shù)據(jù)顯示,PDPN過表達(dá)與患者預(yù)后不良密切相關(guān),其介導(dǎo)的血小板聚集作用可能增加術(shù)后血栓風(fēng)險。
近年針對PDPN的抗體藥物開發(fā)進(jìn)展顯著,日本學(xué)者開發(fā)的NZ-1單抗已在動物實驗中成功抑制腫瘤轉(zhuǎn)移,CAR-T療法針對膠質(zhì)瘤的臨床前研究也顯示出靶向潛力。然而,由于PDPN在正常組織如肺泡細(xì)胞中的基礎(chǔ)表達(dá),藥物研發(fā)需重點解決靶向毒性問題。目前國際上有多個雙特異性抗體項目進(jìn)入Ⅰ期臨床,試圖通過精確調(diào)控抗體親和力平衡療效與安全性。

熱銷產(chǎn)品

PDPN Recombinant Monoclonal Antibody (CSB-RA017739MA1HU)

驗證數(shù)據(jù)

CSB-RA017739MA1HU

Western Blot
Positive WB detected in: PC-3 whole cell lysate, SY5Y whole cell lysate, U251 whole cell lysate, HepG2 whole cell lysate
All lanes: PDPN antibody at 1:1000
Secondary
Goat polyclonal to mouse IgG at 1/50000 dilution
Predicted band size: 17 kDa
Observed band size: 17 kDa

CSB-RA017739MA1HU

IHC image of CSB-RA017739MA1HU diluted at 1:300 and staining in paraffin-embedded human colorectal cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Mouse IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA017739MA1HU

IHC image of CSB-RA017739MA1HU diluted at 1:300 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Mouse IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA017739MA1HU

Overlay Peak curve showing 293 cells stained with CSB-RA017739MA1HU (red line) at 1:100. The cells were fixed in 4% formaldehyde (15min) and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10,026 events was performed.

Human Podoplanin(PDPN) ELISA kit (CSB-EL017739HU)

驗證數(shù)據(jù)

CSB-EL017739HU 標(biāo)準(zhǔn)曲線

貨號:CSB-EL017739HU

規(guī)格:96T/48T

靈敏度:6.25 pg/mL

檢測范圍:25 pg/mL-1600 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

PDPN Antibodies

PDPN for Homo sapiens (Human)

PDPN Proteins

PDPN Proteins for Mus musculus (Mouse)

PDPN Proteins for Rattus norvegicus (Rat)

PDPN Proteins for Homo sapiens (Human)

PDPN Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

PDPN Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

PDPN ELISA Kit

PDPN ELISA Kit for Homo sapiens (Human)



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