在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Dog Podoplanin (PDPN), partial

Recombinant Dog Podoplanin (PDPN), partial

  • 中文名稱：
    熟悉的犬PDPN重組蛋白
  • 貨號：
    CSB-YP017739DO1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    熟悉的犬PDPN重組蛋白
  • 貨號：
    CSB-EP017739DO1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    熟悉的犬PDPN重組蛋白
  • 貨號：
    CSB-EP017739DO1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    熟悉的犬PDPN重組蛋白
  • 貨號：
    CSB-BP017739DO1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    熟悉的犬PDPN重組蛋白
  • 貨號：
    CSB-MP017739DO1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    PDPN; GP40; Podoplanin; Mucin-type membrane protein Gp40; Gp40
  • 種屬：
    Canis familiaris (Dog) (Canis lupus familiaris)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Mediates effects on cell migration and adhesion through its different partners. During development plays a role in blood and lymphatic vessels separation by binding CLEC1B, triggering CLEC1B activation in platelets and leading to platelet activation and/or aggregation. Interaction with CD9, on the contrary, attenuates platelet aggregation and pulmonary metastasis induced by PDPN. Mediates effects on cell migration and adhesion through its different partners. Through MSN or EZR interaction promotes epithelial-mesenchymal transition (EMT) leading to ERZ phosphorylation and triggering RHOA activation leading to cell migration increase and invasiveness. Interaction with CD44 promotes directional cell migration in epithelial and tumor cells. In lymph nodes (LNs), controls fibroblastic reticular cells (FRCs) adhesion to the extracellular matrix (ECM) and contraction of the actomyosin by maintaining ERM proteins (EZR; MSN and RDX) and MYL9 activation through association with unknown transmembrane proteins. Engagement of CLEC1B by PDPN promotes FRCs relaxation by blocking lateral membrane interactions leading to reduction of ERM proteins (EZR; MSN and RDX) and MYL9 activation. Through binding with LGALS8 may participate in connection of the lymphatic endothelium to the surrounding extracellular matrix. In keratinocytes, induces changes in cell morphology showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Controls invadopodia stability and maturation leading to efficient degradation of the extracellular matrix (ECM) in tumor cells through modulation of RHOC activity in order to activate ROCK1/ROCK2 and LIMK1/LIMK2 and inactivation of CFL1. Required for normal lung cell proliferation and alveolus formation at birth. Does not function as a water channel or as a regulator of aquaporin-type water channels. Does not have any effect on folic acid or amino acid transport.
  • 基因功能參考文獻：
    1. PMab-38 is expected to be useful for investigating the function of podoplanin in canine tumors. PMID: 27788030
    2. PMab-38 also detected dPDPN specifically in flow cytometry and Western blot analysis. PMab-38 is expected to be useful for investigating the function of dPDPN, which is expressed in podocytes. PMID: 27380308
    3. Podoplanin is expressed in lymphatic endothelial cells and cancer-associated fibroblasts of oral melanoma tissues. PMID: 27918691
  • 亞細胞定位：
    Membrane; Single-pass type I membrane protein. Cell projection, filopodium membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane; Single-pass type I membrane protein. Cell projection, microvillus membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane; Single-pass type I membrane protein. Membrane raft. Apical cell membrane. Basolateral cell membrane. Cell projection, invadopodium.
  • 蛋白家族：
    Podoplanin family
  • 數據庫鏈接：

    KEGG: cfa:403886

    UniGene: Cfa.3749



主站蜘蛛池模板： 亚洲中文字幕av每天更新| 无套内内射视频网站| 麻豆av一区二区天美传媒 | 全球成人中文在线| 国内久久婷婷六月综合欲色啪| 欧美日韩国产精品| 国产精品欧美一区二区三区不卡| 麻花传媒mv在线观看| 久久亚洲国产精品亚洲老地址| 欧美精品v欧洲精品| 狠狠躁18三区二区一区ai明星| 蜜芽久久人人超碰爱香蕉| av大片在线无码永久免费| 日本十八禁黄无遮禁视频免费| 色哟哟最新在线观看入口| 午夜免费男女aaaa片| 国产成人精品亚洲午夜麻豆| 欧洲免费无线码在线一区| 国产杨幂丝袜av在线播放| 亚洲国产欧美在线人成最新| 黑人巨大精品欧美黑寡妇| 国产av综合影院| 国内外精品激情刺激在线| 欧美成人免费全部观看| 久久久久99精品成人片试看| 亚洲日韩精品a∨片无码加勒比| 久久亚洲人成综合网| 色哟哟免费视频播放网站| 亚洲精品久久久久久久蜜桃臀| 亚洲人亚洲精品成人网站| 青青草国产精品一区二区| 无码被窝影院午夜看片爽爽jk| 天天躁日日躁狠狠躁性色avq| 亚洲日韩一页精品发布| 久久亚洲国产精品影院| 正在播放国产乱子伦最新视频| 欧美成人午夜精品久久久| 亚洲熟妇无码八av在线播放| av色国产色拍| 漂亮人妻被强中文字幕久久| 亚洲欧美日韩精品久久|