在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Dog Podoplanin (PDPN)

  • 中文名稱:
    Recombinant Dog Podoplanin(PDPN)
  • 貨號:
    CSB-CF017739DO
  • 規格:
    ¥10008
  • 其他:

產品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    PDPN; GP40; Podoplanin; Mucin-type membrane protein Gp40; Gp40
  • 種屬:
    Canis lupus familiaris (Dog) (Canis familiaris)
  • 蛋白長度:
    Full Length of Mature Protein
  • 來源:
    in vitro E.coli expression system
  • 表達區域:
    23-169
  • 氨基酸序列
    ASTVRPDDIIPGVEDSVVTPGTEDSVVTPGAEDNVVTDGATEEPYESGLTPLVTKNTESVTDLHLEDGPTQESTVHAKEESQSTTTLNVVTSHSREKVGEDTETTVEKDGLATVTLVGIIVGVLLAIGFIGGIIIVVARKMSGRYSP
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Mediates effects on cell migration and adhesion through its different partners. During development plays a role in blood and lymphatic vessels separation by binding CLEC1B, triggering CLEC1B activation in platelets and leading to platelet activation and/or aggregation. Interaction with CD9, on the contrary, attenuates platelet aggregation and pulmonary metastasis induced by PDPN. Mediates effects on cell migration and adhesion through its different partners. Through MSN or EZR interaction promotes epithelial-mesenchymal transition (EMT) leading to ERZ phosphorylation and triggering RHOA activation leading to cell migration increase and invasiveness. Interaction with CD44 promotes directional cell migration in epithelial and tumor cells. In lymph nodes (LNs), controls fibroblastic reticular cells (FRCs) adhesion to the extracellular matrix (ECM) and contraction of the actomyosin by maintaining ERM proteins (EZR; MSN and RDX) and MYL9 activation through association with unknown transmembrane proteins. Engagement of CLEC1B by PDPN promotes FRCs relaxation by blocking lateral membrane interactions leading to reduction of ERM proteins (EZR; MSN and RDX) and MYL9 activation. Through binding with LGALS8 may participate in connection of the lymphatic endothelium to the surrounding extracellular matrix. In keratinocytes, induces changes in cell morphology showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Controls invadopodia stability and maturation leading to efficient degradation of the extracellular matrix (ECM) in tumor cells through modulation of RHOC activity in order to activate ROCK1/ROCK2 and LIMK1/LIMK2 and inactivation of CFL1. Required for normal lung cell proliferation and alveolus formation at birth. Does not function as a water channel or as a regulator of aquaporin-type water channels. Does not have any effect on folic acid or amino acid transport.
  • 基因功能參考文獻:
    1. PMab-38 is expected to be useful for investigating the function of podoplanin in canine tumors. PMID: 27788030
    2. PMab-38 also detected dPDPN specifically in flow cytometry and Western blot analysis. PMab-38 is expected to be useful for investigating the function of dPDPN, which is expressed in podocytes. PMID: 27380308
    3. Podoplanin is expressed in lymphatic endothelial cells and cancer-associated fibroblasts of oral melanoma tissues. PMID: 27918691
  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein. Cell projection, filopodium membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane; Single-pass type I membrane protein. Cell projection, microvillus membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane; Single-pass type I membrane protein. Membrane raft. Apical cell membrane. Basolateral cell membrane. Cell projection, invadopodium.
  • 蛋白家族:
    Podoplanin family
  • 數據庫鏈接:

    KEGG: cfa:403886

    UniGene: Cfa.3749



主站蜘蛛池模板: 国产偷窥熟女精品视频大全| 2021久久超碰国产精品最新| 国产98在线 | 欧美| 玩弄人妻少妇500系列| 香蕉成人伊视频在线观看| 久久99热这里只有精品国产 | 色欲天天婬色婬香综合网| 亚洲丰满熟女一区二区v| 久久777国产线看观看精品| 强开小婷嫩苞又嫩又紧韩国视频 | 亚洲色偷偷色噜噜狠狠99网| 日韩高清亚洲日韩精品一区| 欧美精品亚洲精品日韩专区| 护士人妻hd中文字幕| 国产超碰人人爽人人做| 日韩乱码在线观看免费视频网站| 99久久精品费精品国产一区二| 国产男女猛烈无遮挡免费视频| 国产成人vr精品a视频| 18禁美女黄网站色大片免费网站| 国产精品自在拍一区二区不卡 | 黑人大荫蒂高潮视频| 国产99视频精品免费视频36| 久青草久青草视频在线观看| 亚洲精品久久一区二区三区777| 天天躁日日躁狠狠躁| 99尹人香蕉国产免费天天| 欧美性色老妇人| 亚洲国产精品第一区二区| 欧美两根一起进3p做受视频| 国产精品星空无限传媒| 奶头好大狂揉60分钟视频 | 国产成人精品视频国产| 国产偷v国产偷v亚洲高清| 日韩一区二区在线观看视频| 国产精品无码久久av不卡| 少妇激情艳情综合小视频| 欧美自拍嘿咻内射在线观看| 久久久久久久岛国免费观看| 无码专区6080yy国产电影| 精品av无码国产一区二区|