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NLRP10

NLRP10,即含NLR家族pyrin結構域10,別名NOD8、PAN5、PYNOD、NALP10、CLR11.1。NLRP10作為信號誘導的多蛋白復合體(炎癥小體)的一部分,激活促炎半胱天冬酶caspase-1和caspase-5,同時NLRP10也被認為是炎癥和細胞凋亡的多功能負調節因子。NLRP10在先天免疫系統中發揮調節作用,參與對其他生物體的防御響應、基于免疫球蛋白超家族結構域的免疫受體的體細胞重組的適應性免疫應答的正調控,以及細胞因子生產的正調控。NLRP10與多種疾病相關,包括Petrositis和神經發育障礙伴不自主運動。

熱銷產品

NLRP10 Antibody (CSB-PA773044LA01HU)

驗證數據

CSB-PA773044LA01HU

Western Blot
Positive WB detected in: Rat heart tissue
All lanes: NLRP10 antibody at 4.9μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 76 kDa
Observed band size: 76 kDa

CSB-PA773044LA01HU

IHC image of CSB-PA773044LA01HU diluted at 1:400 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA773044LA01HU

Immunofluorescence staining of Hela cells with CSB-PA773044LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

NLRP10 Antibodies

NLRP10 for Homo sapiens (Human)

NLRP10 Proteins

NLRP10 Proteins for Homo sapiens (Human)



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