在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. NLRP10 Antibody

NLRP10 Antibody

  • 中文名稱：
    NLRP10兔多克隆抗體
  • 貨號(hào)：
    CSB-PA207849
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA207849(NLRP10 Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA207849(NLRP10 Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    CLR11.1 antibody; NACHT, leucine rich repeat and PYD containing 10 antibody; NACHT, LRR and PYD domains containing protein 10 antibody; NACHT, LRR and PYD domains-containing protein 10 antibody; NAL10_HUMAN antibody; NALP10 antibody; NLR family, pyrin domain containing 10 antibody; Nlrp10 antibody; NOD8 antibody; Nucleotide-binding oligomerization domain protein 8 antibody; Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 10 antibody; PAN5 antibody; PYNOD antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthetic peptide of Human NLRP10
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID. Displays anti-inflammatory activity. Required for immunity against C.albicans infection. Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection. Contributes to T-cell-mediated inflammatory responses in the skin. Plays a role in protection against periodontitis through its involvement in induction of IL1A via ERK activation in oral epithelial cells infected with periodontal pathogens. Exhibits both ATPase and GTPase activities.
  • 基因功能參考文獻(xiàn)：
    1. Authors observed an important role of NLRP10 in cytokine and chemokine production as well as expression of NF-kappaB and MAPKs in CSE-exposed A549 cells. Furthermore, replenishment of A549 cell culture with recombinant IL-17A (rIL-17A) during NLRP10 knockdown rescued CSE-induced inflammatory responses. PMID: 29501574
    2. these data suggest that NLRP10 is involved in activating the ERK signalling pathway in oral epithelial cell line infected with Tannerella forsythia and Fusobacterium nucleatum PMID: 28766990
    3. Review summarize recent advances of the role of of human and murine NLRP10 in innate and adaptive immune responses. [Review] PMID: 23562614
    4. These data revealed a novel role of NLRP10 in innate immune responses towards bacterial infection and suggest that NLRP10 functions as a scaffold for the formation of the NOD1-Nodosome. PMID: 22672233
    5. The results show that either deletion of the p53 binding elements within the PYNOD promoter or treatment with p53 inhibitor could significantly reduce PYNOD promoter activity. PMID: 22365966
    6. Transgenic PYNOD colocalizes with apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) and inhibits caspase-1-mediated interleukin (IL)-1beta processing without inhibiting caspase-4-mediated caspase-1 processing. PMID: 20393137
    7. Observational study of gene-disease association. (HuGE Navigator) PMID: 20403135
    8. PYNOD is a novel regulator of apoptosis and inflammation. PMID: 15096476
    9. PYPAF3 is a feedback regulator of interleukin-1beta secretion, and PYPAF2 and PYPAF3, together with PYNOD, constitute an anti-inflammatory subgroup of PYRIN-containing apoptotic protease-activating factor-1-like proteins PMID: 15817483
    10. The structural modification of the NLRP10 gene might have played a role in development or enhancement of human-specific traits during evolution. PMID: 19544093

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm. Cell membrane; Peripheral membrane protein.
  • 蛋白家族：
    NLRP family
  • 組織特異性：
    Highly expressed in basal and suprabasal epidermal cell layers with lower levels in dermal fibroblast cells (at protein level). Widely expressed with highest levels in heart, brain and skeletal muscle. Also expressed in liver, colon, dermis and epidermis.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 21464

    OMIM: 609662

    KEGG: hsa:338322

    STRING: 9606.ENSP00000327763

    UniGene: Hs.449636



主站蜘蛛池模板： 天天躁久久躁日日躁| 欧美巨大黑人精品videos| 男女久久久国产一区二区三区| 日本xxxx18野外无毒不卡| 亚洲学生妹高清av| 18禁裸体动漫美女无遮挡网站| 99久久婷婷国产综合精品电影| 在线中文字幕乱码英文字幕正常| 老师黑色丝袜被躁翻了av| 精品国产av一区二区果冻传媒 | 日韩成人无码影院| 特级毛片爽www免费版| 久久www香蕉免费人成| 欧美激情猛片xxxⅹ大3| 亚洲国产精品自在拍在线播放蜜臀 | 亚洲综合无码无在线观看| 亚洲精品久久国产高清小说| 欧美亚洲国产片在线播放| 精品国精品国产自在久国产应用| 色欲一区二区三区精品a片| 加比勒色综合久久| 日本一区二区三区免费播放视频站| 久久中文字幕人妻熟女| 黄桃av无码免费一区二区三区| 色综合视频一区二区三区| 免费无码黄动漫十八禁| 国内精品伊人久久久久av影院 | 真人抽搐一进一出gif| 两性色午夜视频免费播放| 猫咪免费人成网站在线观看| 一二三四区无产乱码1000集| 一本一道波多野结衣av黑人| 婷婷色香合缴缴情av第三区| 自拍偷亚洲产在线观看| 欧美中日韩免费观看网站| 成 人 色 网 站免费观看| 又粗又猛又黄又爽无遮挡| 亚洲精品国产自在现线最新| 狠狠躁夜夜躁人人躁婷婷视频| 日韩va中文字幕无码电影| 69天堂人成无码免费视频|