在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. NLRP10 Antibody

NLRP10 Antibody

  • 中文名稱：
    NLRP10兔多克隆抗體
  • 貨號(hào)：
    CSB-PA207849
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA207849(NLRP10 Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA207849(NLRP10 Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    CLR11.1 antibody; NACHT, leucine rich repeat and PYD containing 10 antibody; NACHT, LRR and PYD domains containing protein 10 antibody; NACHT, LRR and PYD domains-containing protein 10 antibody; NAL10_HUMAN antibody; NALP10 antibody; NLR family, pyrin domain containing 10 antibody; Nlrp10 antibody; NOD8 antibody; Nucleotide-binding oligomerization domain protein 8 antibody; Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 10 antibody; PAN5 antibody; PYNOD antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthetic peptide of Human NLRP10
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID. Displays anti-inflammatory activity. Required for immunity against C.albicans infection. Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection. Contributes to T-cell-mediated inflammatory responses in the skin. Plays a role in protection against periodontitis through its involvement in induction of IL1A via ERK activation in oral epithelial cells infected with periodontal pathogens. Exhibits both ATPase and GTPase activities.
  • 基因功能參考文獻(xiàn)：
    1. Authors observed an important role of NLRP10 in cytokine and chemokine production as well as expression of NF-kappaB and MAPKs in CSE-exposed A549 cells. Furthermore, replenishment of A549 cell culture with recombinant IL-17A (rIL-17A) during NLRP10 knockdown rescued CSE-induced inflammatory responses. PMID: 29501574
    2. these data suggest that NLRP10 is involved in activating the ERK signalling pathway in oral epithelial cell line infected with Tannerella forsythia and Fusobacterium nucleatum PMID: 28766990
    3. Review summarize recent advances of the role of of human and murine NLRP10 in innate and adaptive immune responses. [Review] PMID: 23562614
    4. These data revealed a novel role of NLRP10 in innate immune responses towards bacterial infection and suggest that NLRP10 functions as a scaffold for the formation of the NOD1-Nodosome. PMID: 22672233
    5. The results show that either deletion of the p53 binding elements within the PYNOD promoter or treatment with p53 inhibitor could significantly reduce PYNOD promoter activity. PMID: 22365966
    6. Transgenic PYNOD colocalizes with apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) and inhibits caspase-1-mediated interleukin (IL)-1beta processing without inhibiting caspase-4-mediated caspase-1 processing. PMID: 20393137
    7. Observational study of gene-disease association. (HuGE Navigator) PMID: 20403135
    8. PYNOD is a novel regulator of apoptosis and inflammation. PMID: 15096476
    9. PYPAF3 is a feedback regulator of interleukin-1beta secretion, and PYPAF2 and PYPAF3, together with PYNOD, constitute an anti-inflammatory subgroup of PYRIN-containing apoptotic protease-activating factor-1-like proteins PMID: 15817483
    10. The structural modification of the NLRP10 gene might have played a role in development or enhancement of human-specific traits during evolution. PMID: 19544093

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm. Cell membrane; Peripheral membrane protein.
  • 蛋白家族：
    NLRP family
  • 組織特異性：
    Highly expressed in basal and suprabasal epidermal cell layers with lower levels in dermal fibroblast cells (at protein level). Widely expressed with highest levels in heart, brain and skeletal muscle. Also expressed in liver, colon, dermis and epidermis.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 21464

    OMIM: 609662

    KEGG: hsa:338322

    STRING: 9606.ENSP00000327763

    UniGene: Hs.449636



主站蜘蛛池模板： 日本黄网站三级三级三级| 午夜福利理论片高清在线观看 | 亚洲精品国产情侣av在线| 人妻丰满熟妇a无码区| 欧洲美女熟乱av| 国内精品视频一区二区三区| 日韩精品成人无码专区免费| 亚洲精品久久久蜜桃| 狠狠躁夜夜躁人人躁婷婷| 国产精品亚洲玖玖玖在线观看| 亚洲精品久久久www小说 | 国产免费毛卡片| 中文字字幕在线中文无码| 日韩精品一区国产偷窥在线| 久久视热这里只有精品| 日日摸日日碰夜夜爽av| 国产成人精品无码免费看夜聊软件| 快好爽射给我视频| 中文字幕av一区乱码| 2021亚洲国产成a在线| 国产黄大片在线观看| 97午夜理论片在线影院| 欧美大片18禁aaa免费视频| 丰满人妻无奈张开双腿av| 中国熟妇人妻xxxxx| 欧美老熟妇欲乱高清视频| 人人妻一区二区三区| 亚洲综合另类小说色区色噜噜| 亚洲色国产欧美日韩| 情侣做性视频在线播放| 国产肉体xxxx裸体137大胆| 亚洲国产成人久久久网站| 亚洲精品久久久久午夜aⅴ| 国产成人拍精品视频午夜网站| 欧美丰满一区二区免费视频| 亚洲中文字幕乱码一区| 伦埋琪琪久久影院三级| 日本中文字幕有码在线视频 | 亚洲欧美日产综合在线| 中文亚洲欧美日韩无线码| 亚洲国产精品久久网午夜|