在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. NLRP10 Antibody

NLRP10 Antibody

  • 中文名稱：
    NLRP10兔多克隆抗體
  • 貨號：
    CSB-PA197311
  • 規格：
    ￥1100
  • 圖片：
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse heart tissue, Mouse skeletal muscle tissue, Primary antibody: CSB-PA197311(NLRP10 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minutes
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    CLR11.1 antibody; NACHT, leucine rich repeat and PYD containing 10 antibody; NACHT, LRR and PYD domains containing protein 10 antibody; NACHT, LRR and PYD domains-containing protein 10 antibody; NAL10_HUMAN antibody; NALP10 antibody; NLR family, pyrin domain containing 10 antibody; Nlrp10 antibody; NOD8 antibody; Nucleotide-binding oligomerization domain protein 8 antibody; Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 10 antibody; PAN5 antibody; PYNOD antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human NLRP10
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID. Displays anti-inflammatory activity. Required for immunity against C.albicans infection. Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection. Contributes to T-cell-mediated inflammatory responses in the skin. Plays a role in protection against periodontitis through its involvement in induction of IL1A via ERK activation in oral epithelial cells infected with periodontal pathogens. Exhibits both ATPase and GTPase activities.
  • 基因功能參考文獻：
    1. Authors observed an important role of NLRP10 in cytokine and chemokine production as well as expression of NF-kappaB and MAPKs in CSE-exposed A549 cells. Furthermore, replenishment of A549 cell culture with recombinant IL-17A (rIL-17A) during NLRP10 knockdown rescued CSE-induced inflammatory responses. PMID: 29501574
    2. these data suggest that NLRP10 is involved in activating the ERK signalling pathway in oral epithelial cell line infected with Tannerella forsythia and Fusobacterium nucleatum PMID: 28766990
    3. Review summarize recent advances of the role of of human and murine NLRP10 in innate and adaptive immune responses. [Review] PMID: 23562614
    4. These data revealed a novel role of NLRP10 in innate immune responses towards bacterial infection and suggest that NLRP10 functions as a scaffold for the formation of the NOD1-Nodosome. PMID: 22672233
    5. The results show that either deletion of the p53 binding elements within the PYNOD promoter or treatment with p53 inhibitor could significantly reduce PYNOD promoter activity. PMID: 22365966
    6. Transgenic PYNOD colocalizes with apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) and inhibits caspase-1-mediated interleukin (IL)-1beta processing without inhibiting caspase-4-mediated caspase-1 processing. PMID: 20393137
    7. Observational study of gene-disease association. (HuGE Navigator) PMID: 20403135
    8. PYNOD is a novel regulator of apoptosis and inflammation. PMID: 15096476
    9. PYPAF3 is a feedback regulator of interleukin-1beta secretion, and PYPAF2 and PYPAF3, together with PYNOD, constitute an anti-inflammatory subgroup of PYRIN-containing apoptotic protease-activating factor-1-like proteins PMID: 15817483
    10. The structural modification of the NLRP10 gene might have played a role in development or enhancement of human-specific traits during evolution. PMID: 19544093

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Cell membrane; Peripheral membrane protein.
  • 蛋白家族：
    NLRP family
  • 組織特異性：
    Highly expressed in basal and suprabasal epidermal cell layers with lower levels in dermal fibroblast cells (at protein level). Widely expressed with highest levels in heart, brain and skeletal muscle. Also expressed in liver, colon, dermis and epidermis.
  • 數據庫鏈接：

    HGNC: 21464

    OMIM: 609662

    KEGG: hsa:338322

    STRING: 9606.ENSP00000327763

    UniGene: Hs.449636



主站蜘蛛池模板： 国产啪精品视频网站| 亚洲国产精品无码中文字| 狠狠噜狠狠狠狠丁香五月| 人妻熟女一区二区三区app下载 | 国产日产高清欧美一区| 国产色综合天天综合网| 丰满熟妇人妻中文字幕| 人妻免费一区二区三区最新| av在线亚洲欧洲日产一区二区| 久久久久国产精品人妻电影| 色欧美片视频在线观看| 中文字幕亚洲日韩无线码| 色伊人亚洲综合网站| 激烈的性高湖波多野结衣| 中文字幕乱偷无码av先锋| 国产乱子伦精品视频| 99尹人香蕉国产免费天天| 四十如虎的丰满熟妇啪啪| 中文字幕亚洲综合久久青草| 国产av熟女一区二区三区| 女人和拘做爰正片视频| 精品香蕉久久久午夜福利| 久久久久久亚洲综合影院| 欧美精品黑人粗大视频| 香蕉成人伊视频在线观看| 日韩综合亚洲色在线影院| 2019一級特黃色毛片免費看| 无遮挡又黄又刺激的视频| 国产精品日日做人人爱| 少妇仑乱a毛片无码| 2019久久久最新精品| 国产欧美亚洲精品a| 日本一二三区视频在线| 人妻三级日本香港三级极| 国产午夜无码福利在线看网站| 国产精品免费大片| 99久久婷婷国产综合精品| 99久久无码一区人妻a黑| 99国精品午夜福利视频不卡| 国模无码大尺度一区二区三区| 久久久久国精品产熟女久色|