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NGF

NGF,即神經(jīng)生長因子,別名Nerve Growth Factor。它是一種在多種組織中廣泛存在,尤其在中樞和外周神經(jīng)系統(tǒng)中具有重要作用的蛋白質(zhì)。NGF由人體細(xì)胞自身的基因編碼,最初從小鼠腫瘤、蛇毒和雄性小鼠唾液腺中被分離和純化出來 。NGF的作用機(jī)制主要是通過與其高親和力受體TrkA結(jié)合,激活細(xì)胞內(nèi)的酪氨酸激酶活性,進(jìn)而觸發(fā)下游的PI3K-Akt和MAPK等信號(hào)通路,促進(jìn)神經(jīng)元的存活、分化和生長。此外,NGF還能與低親和力受體p75NTR結(jié)合,參與調(diào)節(jié)細(xì)胞凋亡等過程 。在生物學(xué)意義上,NGF對(duì)神經(jīng)系統(tǒng)的發(fā)育和成熟至關(guān)重要,特別是在促進(jìn)特定類型神經(jīng)細(xì)胞的存活和功能表達(dá)方面。NGF的活性還與免疫細(xì)胞的活性調(diào)節(jié)、腫瘤細(xì)胞的有絲分裂抑制以及創(chuàng)口愈合過程相關(guān)。在疾病治療方面,NGF被研究用于治療包括阿爾茨海默病、帕金森病、糖尿病相關(guān)神經(jīng)病變和急性神經(jīng)系統(tǒng)損傷等多種疾病 。

熱銷產(chǎn)品

Recombinant Human Beta-nerve growth factor (NGF) (CSB-EP015779HU)

驗(yàn)證數(shù)據(jù)

CSB-EP015779HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

NGF Recombinant Monoclonal Antibody (CSB-RA015779MA1HU)

驗(yàn)證數(shù)據(jù)

CSB-RA015779MA1HU

Overlay Peak curve showing PC3 cells stained with CSB-RA015779MA1HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-human IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was human IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

NGF Antibodies

NGF for Rattus norvegicus (Rat)

NGF for Homo sapiens (Human)

NGF for Pig

NGF Proteins

NGF Proteins for Bos taurus (Bovine)

NGF Proteins for Cavia porcellus (Guinea pig)

NGF Proteins for Rattus norvegicus (Rat)

NGF Proteins for Homo sapiens (Human)

NGF Proteins for Gallus gallus (Chicken)

NGF Proteins for Mus musculus (Mouse)

NGF Proteins for Praomys natalensis (African soft-furred rat) (Mastomys natalensis)

NGF Proteins for Xenopus laevis (African clawed frog)

NGF Proteins for Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus)

NGF Proteins for Sus scrofa (Pig)

NGF Proteins for Saimiri boliviensis boliviensis (Bolivian squirrel monkey)

NGF Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

NGF Proteins for Bothrops jararacussu (Jararacussu)

NGF Proteins for Gorilla gorilla gorilla (Lowland gorilla)

NGF Proteins for Pongo pygmaeus (Bornean orangutan)

NGF Proteins for Pan troglodytes (Chimpanzee)

NGF ELISA Kit

NGF ELISA Kit for Homo sapiens (Human)

NGF ELISA Kit for Mus musculus (Mouse)

NGF ELISA Kit for Rattus norvegicus (Rat)



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