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LSR

LSR,全稱為緊密連接蛋白LSR(Lens-shaped protein-related),是一種參與細胞緊密連接形成的蛋白質。該蛋白常見別名包括Lsrin、TJP2等。LSR蛋白在細胞中主要通過與其他緊密連接蛋白相互作用,參與維持細胞膜的完整性和選擇性通透性,對腸道屏障功能尤為重要。研究發現,LSR蛋白能夠與新冠病毒受體ACE2結合,阻止病毒刺突蛋白與其結合,從而抑制病毒入侵細胞。此外,LSR蛋白的缺失會增強ACE2依賴性SARS-CoV-2病毒的感染,而外源性補充LSR蛋白則能有效保護宿主免受病毒感染。這一發現為開發抗新冠病毒藥物提供了新的靶點。目前,基于LSR蛋白的短肽已被證實能在體外阻斷S蛋白與ACE2受體的結合,展現出治療和干預冠狀病毒變異株的潛力。此外,LSR蛋白的異常表達與某些癌癥的發生發展密切相關,因此也成為癌癥免疫治療的重要靶點。針對LSR蛋白的抗體藥物和衍生短肽等正在研發中,有望為相關疾病的治療提供新的選擇。

熱銷產品

Recombinant Human Lipolysis-stimulated lipoprotein receptor (LSR), partial (CSB-EP801252HU)

驗證數據

CSB-EP801252HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-EP801252HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP801252HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) LSR.

CSB-EP801252HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP801252HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) LSR.

LSR Antibody (CSB-PA801252LA01HU)

驗證數據

CSB-PA801252LA01HU

IHC image of CSB-PA801252LA01HU diluted at 1:400 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA801252LA01HU

Immunofluorescence staining of HepG2 cells with CSB-PA801252LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Human Lipolysis-stimulated lipoprotein receptor(LSR) ELISA kit (CSB-EL013215HU)

驗證數據

CSB-EL013215HU 標準曲線

貨號:CSB-EL013215HU

規格:96T/48T

靈敏度:1.56 pg/mL

檢測范圍:6.25 pg/mL-400 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

LSR Antibodies

LSR for Homo sapiens (Human)

LSR Proteins

LSR Proteins for Homo sapiens (Human)

LSR ELISA Kit

LSR ELISA Kit for Homo sapiens (Human)



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