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APOE

APOE,即載脂蛋白E,別名 AD2、APOEA、LDLCQ5、LPG。APOE是一種多態性蛋白,由肝臟、小腸和大腦等組織產生,主要功能是結合脂質并形成脂蛋白顆粒,介導脂質在體內的運輸和代謝。APOE的作用機制涉及與多種細胞表面受體的相互作用,如低密度脂蛋白受體(LDLR)、清道夫受體BI(SR-BI)等,通過這些受體介導脂蛋白的內吞和脂質的細胞內運輸。APOE4是阿爾茨海默病最強的遺傳風險因子之一,其與某些免疫細胞表面的受體LilrB3特異性結合,可能通過干擾小膠質細胞的吞噬功能,促進β-淀粉樣蛋白(Aβ)沉積,從而增加阿爾茨海默病的發病風險。APOE不僅在脂質代謝中發揮關鍵作用,還與多種疾病的發生發展密切相關。APOE的這些多態性為研究脂質代謝、神經系統疾病以及開發新的治療策略提供了重要的分子基礎。

熱銷產品

APOE Antibody (CSB-PA07599A0Rb)

驗證數據

CSB-PA07599A0Rb

Immunofluorescence staining of HepG2 cells with CSB-PA07599A0Rb at 1:333, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CSB-PA07599A0Rb

IHC image of CSB-PA07599A0Rb diluted at 1:1000 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Human apolipoprotein E (Apo-E) ELISA Kit (CSB-E09748h)

驗證數據

CSB-E09748h 標準曲線

貨號:CSB-E09748h

規格:96T/48T

靈敏度:3.9 ng/mL

檢測范圍:15.62 ng/mL-1000 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

APOE Antibodies

APOE for Mus musculus (Mouse)

APOE for Homo sapiens (Human)

APOE Proteins

APOE Proteins for Oryctolagus cuniculus (Rabbit)

APOE Proteins for Sus scrofa (Pig)

APOE Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

APOE Proteins for Cavia porcellus (Guinea pig)

APOE Proteins for Homo sapiens (Human)

APOE Proteins for Mus musculus (Mouse)

APOE Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

APOE Proteins for Rattus norvegicus (Rat)

APOE Proteins for Papio anubis (Olive baboon)

APOE Proteins for Ovis aries (Sheep)

APOE Proteins for Zalophus californianus (California sealion)

APOE Proteins for Gorilla gorilla gorilla (Lowland gorilla)

APOE Proteins for Hylobates lar (Common gibbon)

APOE Proteins for Tupaia glis (Tree shrew)

APOE Proteins for Pan troglodytes (Chimpanzee)

APOE Proteins for Pongo pygmaeus (Bornean orangutan)

APOE Proteins for Macaca mulatta (Rhesus macaque)

APOE Proteins for Saimiri sciureus (Common squirrel monkey)

APOE ELISA Kit

APOE ELISA Kit for Homo sapiens (Human)

APOE ELISA Kit for Monkey

APOE ELISA Kit for Mus musculus (Mouse)

APOE ELISA Kit for Rattus norvegicus (Rat)

APOE ELISA Kit for Sus scrofa (Pig)



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