在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Semaphorin-4A (SEMA4A), partial

Recombinant Human Semaphorin-4A (SEMA4A), partial

  • 中文名稱：
    人SEMA4A重組蛋白
  • 貨號：
    CSB-YP884461HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SEMA4A重組蛋白
  • 貨號：
    CSB-EP884461HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人SEMA4A重組蛋白
  • 貨號：
    CSB-EP884461HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SEMA4A重組蛋白
  • 貨號：
    CSB-BP884461HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SEMA4A重組蛋白
  • 貨號：
    CSB-MP884461HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    CORD10; RP11 54H19 2; RP35; SEM4A_HUMAN; Sema B; Sema domain immunoglobulin domain Ig transmembrane domain TM and short cytoplasmic domain 4A; Sema domain immunoglobulin domain Ig transmembrane domain TM and short cytoplasmic domain semaphorin 4A; Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin); Sema4a; SEMAB; Semaphorin 4A precursor; Semaphorin B; Semaphorin-4A; Semaphorin-B; SEMB
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling. Regulates glutamatergic and GABAergic synapse development. Promotes the development of inhibitory synapses in a PLXNB1-dependent manner and promotes the development of excitatory synapses in a PLXNB2-dependent manner. Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity. Promotes phosphorylation of TIMD2. Inhibits angiogenesis. Promotes axon growth cone collapse. Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.
  • 基因功能參考文獻：
    1. Human oligodendrocytes undergo apoptosis when exposed to Sema4A and take up H-ferritin for meeting iron requirements and that these functions are mediated via the Tim-1 receptor. H-ferritin can block Sema4A-mediated cytotoxicity. Sema4A is detectable in the CSF of multiple sclerosis patients and HIV-seropositive persons and can induce oligodendrocyte cell death. PMID: 29457657
    2. Advanced peri-implantitis lesions showed higher levels of gene expression for Sem3A and Sem4D and lower levels of Sem4A in comparison to tissues obtained from a healthy dental implant. PMID: 29763494
    3. Here we show three families with retinal degeneration in which unaffected family members are either homozygous or heterozygous for the variant. The p.R713Q variant in SEMA4A is insufficient to cause either autosomal recessive or autosomal dominant retinitis pigmentosa and is unlikely to be pathogenic. PMID: 28805479
    4. ILT-4 is a receptor for hSEMA4A)on activated CD4(+) T cells. hSEMA4A is highly expressed in human asthmatic lung tissue. PMID: 29467366
    5. Suggest a role for Plexin-B1 as a ligand and Sema4A as a receptor and characterize a reverse signaling pathway downstream of Sema4A regulating cell migration via Scrib. PMID: 28007914
    6. SEMA 4A confers doxorubicin resistance on hepatocellular carcinoma by inducing epithelialemesenchymal transition. PMID: 27697528
    7. In this review, we summarized the current findings on neuroimmune Sema4A and Sema4D molecules in chronic inflammation underlying many diseases and discussed their positive or negative impacts on the implicated molecular and cellular processes PMID: 27554682
    8. Sema4A activated the Akt pathway via Plexin D1 receptor in lung fibroblasts.Lung fibroblasts show elevated levels of Sema4A expression in systemic sclerosis patients. PMID: 26648031
    9. Data suggest that increased expression of semaphorin 4A (Sema4A) is required to promote inflammation of rheumatoid arthritis (RA). PMID: 26303122
    10. Germline variants in SEMA4A predispose to familial colorectal cancer type X. PMID: 25307848
    11. PACAP released from retinal neural cells (photoreceptors or optic nerve cells) may regulate Sema4A expression in retinal pigment epithelial cells and thereby contribute to the maintenance of retinal structure and function. PMID: 25515530
    12. These results indicate the importance of the Sema4A protein conformation in human and mouse retina homeostasis. PMID: 23360997
    13. Sema4A plays an inhibitory role in T helper (Th)2-type allergic diseases, such as allergic asthma, in a fraction of Sema4a-deficient transgenic mice. PMID: 23007237
    14. mutations in SEMA4A may cause susceptibility to light exposure, oxidative stress, and ER stress, which may be involved in the progression and pathology of RP. PMID: 22956603
    15. Dendritic cell-derived SEM4A is not only critical for T helper type (Th)1 cells but also for Th17 cell differentiation, and multiple sclerosis patients with high Sema4A levels exhibit Th17 cell skewing. PMID: 22491253
    16. Mutations within the SEMA4A gene cause various retinal degnerative diseases. PMID: 16199541

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Retinitis pigmentosa 35 (RP35); Cone-rod dystrophy 10 (CORD10)
  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Semaphorin family
  • 數據庫鏈接：

    HGNC: 10729

    OMIM: 607292

    KEGG: hsa:64218

    STRING: 9606.ENSP00000347117

    UniGene: Hs.408846



主站蜘蛛池模板： 男女一边摸一边做爽爽| 精品国产乱码久久久软件下载| 青青草在在观免费福利线观看| 久久久久久久曰本精品免费看| 韩国和日本免费不卡在线v| 欧美婷婷六月丁香综合色| 98久9在线 | 免费| 国产成人精品一区二区三区视频| 欧美亚洲色综久久精品国产| 欧美午夜精品久久久久久浪潮| 亚洲国产成人av在线观看| 麻豆精品人妻一区二区三区蜜桃| 久久九九兔免费精品6| 一本大道大臿蕉视频无码| 狠狠人妻久久久久久综合蜜桃| 无码 人妻 在线 视频| 妖精色av无码国产在线看| 西欧free性满足hd| 成人亚洲性情网站www在线观看| 夜夜国产亚洲视频香蕉| 久久影院午夜理论片无码| 成人无码av一区二区三区| 亚洲日本一区二区三区在线| 337p粉嫩大胆噜噜噜 | 国产人妻黑人一区二区三区| 国产午夜a理论毛片| 2020久热爱精品视频在线观看| 麻豆精品久久久久久久99蜜桃| 曰韩免费无码av一区二区| 无码中文字幕人妻在线一区| 欧美在线观看免费专区| 日本无码欧美一区精品久久| 成人午夜无码专区性视频性视频| 极品粉嫩福利午夜在线播放 | 中国性少妇内射xxxx狠干| 99爱在线精品视频免费观看| 女人被强╳到高潮喷水在线观看 | 国产亚洲精品97在线视频一| 亚洲成在人网站无码天堂| 精品人妻无码一区二区色欲产成人 | 国产又爽又黄无码无遮挡在线观看|