在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SEMA4A Antibody

  • 中文名稱:
    SEMA4A兔多克隆抗體
  • 貨號:
    CSB-PA004061
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of Jurkat cells using SEMA4A Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    CORD10 antibody; RP11 54H19 2 antibody; RP35 antibody; SEM4A_HUMAN antibody; Sema B antibody; Sema domain immunoglobulin domain Ig transmembrane domain TM and short cytoplasmic domain 4A antibody; Sema domain immunoglobulin domain Ig transmembrane domain TM and short cytoplasmic domain semaphorin 4A antibody; Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) antibody; Sema4a antibody; SEMAB antibody; Semaphorin 4A precursor antibody; Semaphorin B antibody; Semaphorin-4A antibody; Semaphorin-B antibody; SEMB antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat,Monkey
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human SEMA4A.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling. Regulates glutamatergic and GABAergic synapse development. Promotes the development of inhibitory synapses in a PLXNB1-dependent manner and promotes the development of excitatory synapses in a PLXNB2-dependent manner. Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity. Promotes phosphorylation of TIMD2. Inhibits angiogenesis. Promotes axon growth cone collapse. Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.
  • 基因功能參考文獻:
    1. Human oligodendrocytes undergo apoptosis when exposed to Sema4A and take up H-ferritin for meeting iron requirements and that these functions are mediated via the Tim-1 receptor. H-ferritin can block Sema4A-mediated cytotoxicity. Sema4A is detectable in the CSF of multiple sclerosis patients and HIV-seropositive persons and can induce oligodendrocyte cell death. PMID: 29457657
    2. Advanced peri-implantitis lesions showed higher levels of gene expression for Sem3A and Sem4D and lower levels of Sem4A in comparison to tissues obtained from a healthy dental implant. PMID: 29763494
    3. Here we show three families with retinal degeneration in which unaffected family members are either homozygous or heterozygous for the variant. The p.R713Q variant in SEMA4A is insufficient to cause either autosomal recessive or autosomal dominant retinitis pigmentosa and is unlikely to be pathogenic. PMID: 28805479
    4. ILT-4 is a receptor for hSEMA4A)on activated CD4(+) T cells. hSEMA4A is highly expressed in human asthmatic lung tissue. PMID: 29467366
    5. Suggest a role for Plexin-B1 as a ligand and Sema4A as a receptor and characterize a reverse signaling pathway downstream of Sema4A regulating cell migration via Scrib. PMID: 28007914
    6. SEMA 4A confers doxorubicin resistance on hepatocellular carcinoma by inducing epithelialemesenchymal transition. PMID: 27697528
    7. In this review, we summarized the current findings on neuroimmune Sema4A and Sema4D molecules in chronic inflammation underlying many diseases and discussed their positive or negative impacts on the implicated molecular and cellular processes PMID: 27554682
    8. Sema4A activated the Akt pathway via Plexin D1 receptor in lung fibroblasts.Lung fibroblasts show elevated levels of Sema4A expression in systemic sclerosis patients. PMID: 26648031
    9. Data suggest that increased expression of semaphorin 4A (Sema4A) is required to promote inflammation of rheumatoid arthritis (RA). PMID: 26303122
    10. Germline variants in SEMA4A predispose to familial colorectal cancer type X. PMID: 25307848
    11. PACAP released from retinal neural cells (photoreceptors or optic nerve cells) may regulate Sema4A expression in retinal pigment epithelial cells and thereby contribute to the maintenance of retinal structure and function. PMID: 25515530
    12. These results indicate the importance of the Sema4A protein conformation in human and mouse retina homeostasis. PMID: 23360997
    13. Sema4A plays an inhibitory role in T helper (Th)2-type allergic diseases, such as allergic asthma, in a fraction of Sema4a-deficient transgenic mice. PMID: 23007237
    14. mutations in SEMA4A may cause susceptibility to light exposure, oxidative stress, and ER stress, which may be involved in the progression and pathology of RP. PMID: 22956603
    15. Dendritic cell-derived SEM4A is not only critical for T helper type (Th)1 cells but also for Th17 cell differentiation, and multiple sclerosis patients with high Sema4A levels exhibit Th17 cell skewing. PMID: 22491253
    16. Mutations within the SEMA4A gene cause various retinal degnerative diseases. PMID: 16199541

    顯示更多

    收起更多

  • 相關疾病:
    Retinitis pigmentosa 35 (RP35); Cone-rod dystrophy 10 (CORD10)
  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Semaphorin family
  • 數據庫鏈接:

    HGNC: 10729

    OMIM: 607292

    KEGG: hsa:64218

    STRING: 9606.ENSP00000347117

    UniGene: Hs.408846



主站蜘蛛池模板: 久久久受www免费人成| 思思99re6国产在线播放| 免费观看又色又爽又黄的韩国| 国产人妻久久精品二区三区特黄| 午夜免费国产体验区免费的| 精品国产国语对白久久免费 | 国产成人无码精品午夜福利a| 亚欧无线一线二线三线区别| 少妇人妻上班偷人精品视频| 无套内谢少妇毛片aaaa片免费| 亚洲精品一区二区国产精华液| 亚洲全部无码中文字幕| 欧美性受xxxx狂喷水| 成人做爰69片免费看网站| 给我免费的视频在线观看| 国产人成网线在线播放va| 内射一区二区精品视频在线观看| 久久中文字幕人妻熟女| 成人区人妻精品一区二区三区| 日本人妻丰满熟妇久久久久久 | 天天躁日日躁狠狠躁人妻| 亚洲中文在线精品国产| 丰满少妇人妻无码专区 | 久久久久久无码午夜精品直播| 亚洲国产精品成人久久| 国模裸体无码xxxx视频| 又湿又黄裸乳漫画无遮挡网站| 国产sp调教打屁股视频网站| 国产欧美日韩精品丝袜高跟鞋| 夜夜高潮夜夜爽夜夜爱| 东京热一区二区三区无码视频| 忘忧草社区中文字幕www| 亚洲精品宾馆在线精品酒店| 欧美35页视频在线观看| 妺妺窝人体色www看人体| 99久久国产宗和精品1上映| 国产成人亚洲综合青青| 欧美成 人 网 站 免费| 日韩精品无码一区二区三区久久久| 欧美精品国产aⅴ一区二区在线 | 中文字幕无码中文字幕有码|