在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Semaphorin-4A (SEMA4A), partial

  • 中文名稱:
    人SEMA4A重組蛋白
  • 貨號:
    CSB-YP884461HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人SEMA4A重組蛋白
  • 貨號:
    CSB-EP884461HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人SEMA4A重組蛋白
  • 貨號:
    CSB-EP884461HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人SEMA4A重組蛋白
  • 貨號:
    CSB-BP884461HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人SEMA4A重組蛋白
  • 貨號:
    CSB-MP884461HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    CORD10; RP11 54H19 2; RP35; SEM4A_HUMAN; Sema B; Sema domain immunoglobulin domain Ig transmembrane domain TM and short cytoplasmic domain 4A; Sema domain immunoglobulin domain Ig transmembrane domain TM and short cytoplasmic domain semaphorin 4A; Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin); Sema4a; SEMAB; Semaphorin 4A precursor; Semaphorin B; Semaphorin-4A; Semaphorin-B; SEMB
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling. Regulates glutamatergic and GABAergic synapse development. Promotes the development of inhibitory synapses in a PLXNB1-dependent manner and promotes the development of excitatory synapses in a PLXNB2-dependent manner. Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity. Promotes phosphorylation of TIMD2. Inhibits angiogenesis. Promotes axon growth cone collapse. Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.
  • 基因功能參考文獻:
    1. Human oligodendrocytes undergo apoptosis when exposed to Sema4A and take up H-ferritin for meeting iron requirements and that these functions are mediated via the Tim-1 receptor. H-ferritin can block Sema4A-mediated cytotoxicity. Sema4A is detectable in the CSF of multiple sclerosis patients and HIV-seropositive persons and can induce oligodendrocyte cell death. PMID: 29457657
    2. Advanced peri-implantitis lesions showed higher levels of gene expression for Sem3A and Sem4D and lower levels of Sem4A in comparison to tissues obtained from a healthy dental implant. PMID: 29763494
    3. Here we show three families with retinal degeneration in which unaffected family members are either homozygous or heterozygous for the variant. The p.R713Q variant in SEMA4A is insufficient to cause either autosomal recessive or autosomal dominant retinitis pigmentosa and is unlikely to be pathogenic. PMID: 28805479
    4. ILT-4 is a receptor for hSEMA4A)on activated CD4(+) T cells. hSEMA4A is highly expressed in human asthmatic lung tissue. PMID: 29467366
    5. Suggest a role for Plexin-B1 as a ligand and Sema4A as a receptor and characterize a reverse signaling pathway downstream of Sema4A regulating cell migration via Scrib. PMID: 28007914
    6. SEMA 4A confers doxorubicin resistance on hepatocellular carcinoma by inducing epithelialemesenchymal transition. PMID: 27697528
    7. In this review, we summarized the current findings on neuroimmune Sema4A and Sema4D molecules in chronic inflammation underlying many diseases and discussed their positive or negative impacts on the implicated molecular and cellular processes PMID: 27554682
    8. Sema4A activated the Akt pathway via Plexin D1 receptor in lung fibroblasts.Lung fibroblasts show elevated levels of Sema4A expression in systemic sclerosis patients. PMID: 26648031
    9. Data suggest that increased expression of semaphorin 4A (Sema4A) is required to promote inflammation of rheumatoid arthritis (RA). PMID: 26303122
    10. Germline variants in SEMA4A predispose to familial colorectal cancer type X. PMID: 25307848
    11. PACAP released from retinal neural cells (photoreceptors or optic nerve cells) may regulate Sema4A expression in retinal pigment epithelial cells and thereby contribute to the maintenance of retinal structure and function. PMID: 25515530
    12. These results indicate the importance of the Sema4A protein conformation in human and mouse retina homeostasis. PMID: 23360997
    13. Sema4A plays an inhibitory role in T helper (Th)2-type allergic diseases, such as allergic asthma, in a fraction of Sema4a-deficient transgenic mice. PMID: 23007237
    14. mutations in SEMA4A may cause susceptibility to light exposure, oxidative stress, and ER stress, which may be involved in the progression and pathology of RP. PMID: 22956603
    15. Dendritic cell-derived SEM4A is not only critical for T helper type (Th)1 cells but also for Th17 cell differentiation, and multiple sclerosis patients with high Sema4A levels exhibit Th17 cell skewing. PMID: 22491253
    16. Mutations within the SEMA4A gene cause various retinal degnerative diseases. PMID: 16199541

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Retinitis pigmentosa 35 (RP35); Cone-rod dystrophy 10 (CORD10)
  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Semaphorin family
  • 數據庫鏈接:

    HGNC: 10729

    OMIM: 607292

    KEGG: hsa:64218

    STRING: 9606.ENSP00000347117

    UniGene: Hs.408846



主站蜘蛛池模板: 少妇仑乱a毛片无码| 国产成人av在线影院| 精品久久久久久久久久久国产字幕| 97久久国产露脸精品国产| av无码午夜福利一区二区三区 | 欧美乱大交aaaa片if| 国产台湾无码av片在线观看| 国产成人精品久久| 欧美猛少妇色xxxxx猛叫| 国产在线 | 中文| 日产精品卡二卡三卡四卡乱码视频 | 亚洲精品久久久av无码专区| 在线欧美中文字幕农村电影| 免费看成人欧美片爱潮app| 国产午夜片无码区在线观看爱情网 | 51精品国产人成在线观看| 中文字幕乱妇无码av在线| 国产人妻黑人一区二区三区 | 最近高清中文在线字幕在线观看1| 成人无码亚洲精品无码| 国产高清在线a视频大全| 插鸡网站在线播放免费观看| 久久精品囯产精品亚洲| 又色又爽又黄高潮的免费视频| 大地资源中文第三页| 久久久久99人妻一区二区三区 | 日本三级手机在线播放线观看 | 婷婷色婷婷开心五月四房播播| 国产精品乱码一区二区三| 免费人成在线视频无码| 中文字幕亚洲码在线观看| 色综合久久精品亚洲国产| 伊人久久大香线蕉av波多野结衣| 国内精品一区二区三区不卡| 天堂在线中文| 久久亚洲一区二区三区四区五区| 狠狠久久精品中文字幕无码| 四虎成人精品永久在线视频| 国内老熟妇对白hdxxxx| 国产亚洲视频在线播放香蕉| 欧美人与动牲交免费观看网|