在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Semaphorin-4A (SEMA4A), partial

Recombinant Human Semaphorin-4A (SEMA4A), partial

  • 中文名稱：
    人SEMA4A重組蛋白
  • 貨號：
    CSB-YP884461HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SEMA4A重組蛋白
  • 貨號：
    CSB-EP884461HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人SEMA4A重組蛋白
  • 貨號：
    CSB-EP884461HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SEMA4A重組蛋白
  • 貨號：
    CSB-BP884461HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SEMA4A重組蛋白
  • 貨號：
    CSB-MP884461HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    CORD10; RP11 54H19 2; RP35; SEM4A_HUMAN; Sema B; Sema domain immunoglobulin domain Ig transmembrane domain TM and short cytoplasmic domain 4A; Sema domain immunoglobulin domain Ig transmembrane domain TM and short cytoplasmic domain semaphorin 4A; Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin); Sema4a; SEMAB; Semaphorin 4A precursor; Semaphorin B; Semaphorin-4A; Semaphorin-B; SEMB
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling. Regulates glutamatergic and GABAergic synapse development. Promotes the development of inhibitory synapses in a PLXNB1-dependent manner and promotes the development of excitatory synapses in a PLXNB2-dependent manner. Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity. Promotes phosphorylation of TIMD2. Inhibits angiogenesis. Promotes axon growth cone collapse. Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.
  • 基因功能參考文獻：
    1. Human oligodendrocytes undergo apoptosis when exposed to Sema4A and take up H-ferritin for meeting iron requirements and that these functions are mediated via the Tim-1 receptor. H-ferritin can block Sema4A-mediated cytotoxicity. Sema4A is detectable in the CSF of multiple sclerosis patients and HIV-seropositive persons and can induce oligodendrocyte cell death. PMID: 29457657
    2. Advanced peri-implantitis lesions showed higher levels of gene expression for Sem3A and Sem4D and lower levels of Sem4A in comparison to tissues obtained from a healthy dental implant. PMID: 29763494
    3. Here we show three families with retinal degeneration in which unaffected family members are either homozygous or heterozygous for the variant. The p.R713Q variant in SEMA4A is insufficient to cause either autosomal recessive or autosomal dominant retinitis pigmentosa and is unlikely to be pathogenic. PMID: 28805479
    4. ILT-4 is a receptor for hSEMA4A)on activated CD4(+) T cells. hSEMA4A is highly expressed in human asthmatic lung tissue. PMID: 29467366
    5. Suggest a role for Plexin-B1 as a ligand and Sema4A as a receptor and characterize a reverse signaling pathway downstream of Sema4A regulating cell migration via Scrib. PMID: 28007914
    6. SEMA 4A confers doxorubicin resistance on hepatocellular carcinoma by inducing epithelialemesenchymal transition. PMID: 27697528
    7. In this review, we summarized the current findings on neuroimmune Sema4A and Sema4D molecules in chronic inflammation underlying many diseases and discussed their positive or negative impacts on the implicated molecular and cellular processes PMID: 27554682
    8. Sema4A activated the Akt pathway via Plexin D1 receptor in lung fibroblasts.Lung fibroblasts show elevated levels of Sema4A expression in systemic sclerosis patients. PMID: 26648031
    9. Data suggest that increased expression of semaphorin 4A (Sema4A) is required to promote inflammation of rheumatoid arthritis (RA). PMID: 26303122
    10. Germline variants in SEMA4A predispose to familial colorectal cancer type X. PMID: 25307848
    11. PACAP released from retinal neural cells (photoreceptors or optic nerve cells) may regulate Sema4A expression in retinal pigment epithelial cells and thereby contribute to the maintenance of retinal structure and function. PMID: 25515530
    12. These results indicate the importance of the Sema4A protein conformation in human and mouse retina homeostasis. PMID: 23360997
    13. Sema4A plays an inhibitory role in T helper (Th)2-type allergic diseases, such as allergic asthma, in a fraction of Sema4a-deficient transgenic mice. PMID: 23007237
    14. mutations in SEMA4A may cause susceptibility to light exposure, oxidative stress, and ER stress, which may be involved in the progression and pathology of RP. PMID: 22956603
    15. Dendritic cell-derived SEM4A is not only critical for T helper type (Th)1 cells but also for Th17 cell differentiation, and multiple sclerosis patients with high Sema4A levels exhibit Th17 cell skewing. PMID: 22491253
    16. Mutations within the SEMA4A gene cause various retinal degnerative diseases. PMID: 16199541

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Retinitis pigmentosa 35 (RP35); Cone-rod dystrophy 10 (CORD10)
  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Semaphorin family
  • 數據庫鏈接：

    HGNC: 10729

    OMIM: 607292

    KEGG: hsa:64218

    STRING: 9606.ENSP00000347117

    UniGene: Hs.408846



主站蜘蛛池模板： 女同性av片在线观看免费网站| 丁香五月缴情在线| 欧美成人a天堂片在线观看| 日韩免费无码人妻波多野| 国产精品欧美成人| 国精产品蘑菇一区一区有限| 爱久久av一区二区三区| 国产成人精品无码播放| 亚洲日韩中文第一精品| 中文字幕一区二区人妻电影| 国产在线精品视频二区| 国产精品久久久久电影网| 国产成人久久av免费| 久久综合香蕉国产蜜臀av| 老太婆性杂交视频| 免费观看的av在线播放| 久久中文字幕乱码久久午夜| 玖玖资源站无码专区| 国产午夜精品一区二区三区| 午夜阳光精品一区二区三区| 99精品国产一区二区三区| 日日碰狠狠躁久久躁2023| 久久亚洲精品无码观看不卡| 欧美欧洲成本大片免费| 亚洲日韩精品无码专区| 中文无码成人免费视频在线观看| 纯肉无遮挡无码日本动漫| 92国产精品午夜福利无毒不卡| 精品免费国产一区二区三区四区介绍| 国产色视频一区二区三区qq号| 人妻互换 综合| 久久久久久妓女精品影院| 中国少妇内射xxxxx-百度| 国产日产久久高清欧美一区 | 国产成人久久久精品二区三区| 久久久久久a亚洲欧洲av冫| 少妇做爰免费视频网站| 国产精品久久综合免费| 青青草国产三级精品三级| 欧美日韩精品一区二区在线观看 | 亚在线观看免费视频入口|